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Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer

Nature medicine, 2018-05, Vol.24 (5), p.638-646

2018

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Resistance Mechanisms to Targeted Therapies in ROS1 + and ALK + Non-small Cell Lung Cancer

Clinical cancer research, 2018-07, Vol.24 (14), p.3334-3347

2018

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Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes

Clinical cancer research, 2021-03, Vol.27 (5), p.1463-1475

2021

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Abstract 4025: STEAP4 ISH and IHC diagnostics for Tarloxotinib activation in EGFR/HER2 mutant cancers

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4025-4025

2019

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Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance

PloS one, 2013-05, Vol.8 (5), p.e64521-e64521

2013

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ERBB family fusions are recurrent and actionable oncogenic targets across cancer types

Frontiers in oncology, 2023-04, Vol.13, p.1115405-1115405

2023

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Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome

The FASEB journal, 2014-01, Vol.28 (1), p.195-205

2014

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Functional complexity of the axonal growth cone: a proteomic analysis

PloS one, 2012-02, Vol.7 (2), p.e31858-e31858

2012

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Dynamic adhesions and MARCKS in melanoma cells

Journal of cell science, 2009-07, Vol.122 (13), p.2300-2310

2009

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Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding

Molecular biology of the cell, 2006-12, Vol.17 (12), p.5115-5130

2006

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Kv1 Potassium Channel Complexes In Vivo Require Kvβ2 Subunits in Dorsal Spinal Neurons

Journal of neurophysiology, 2008-10, Vol.100 (4), p.2125-2136

2008

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"When the Going Gets Tough": Novel Roles for TRPV4 in Stiffness-induced Phagolysosome Maturation

American journal of respiratory cell and molecular biology, 2024-06, Vol.70 (6), p.431-432

2024

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Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma

Neuro-oncology (Charlottesville, Va.), 2012-04, Vol.14 (4), p.405-415

2012

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An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101

Cancer discovery, 2015-10, Vol.5 (10), p.1049-1057

2015

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Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair

Nucleic acids research, 2021-11, Vol.49 (19), p.11067-11082

2021

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Abstract 2202: Tarloxotinib exhibits potent activity in NRG1 fusion and rearranged cancers

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.2202-2202

2019

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Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling

Molecular pharmacology, 2021-06, Vol.99 (6), p.435-447

2021

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MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways

Cell cycle (Georgetown, Tex.), 2015-01, Vol.14 (23), p.3713-3724

2015

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Abstract 6387: Therapeutic targeting of lipid oxidation and apoptosis in pancreatic ductal adenocarcinoma

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.6387-6387

2020

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Abstract C65: TRK kinase domain mutations that induce resistance to a pan-TRK inhibitor

Molecular cancer therapeutics, 2015-12, Vol.14 (12_Supplement_2), p.C65-C65

2015

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Abstract A157: Antitumor activity of tarloxotinib, a hypoxia-activated EGFR TKI, in patient-derived lung cancer cell lines harboring EGFR exon 20 insertions

Molecular cancer therapeutics, 2018-01, Vol.17 (1_Supplement), p.A157-A157

2018

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Abstract A29: The CUTO panel of patient-derived NSCLC cell lines reveals unique molecular characteristics and responses to targeted therapies

Clinical cancer research, 2018-09, Vol.24 (17_Supplement), p.A29-A29

2018

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ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer

Oncotarget, 2018-02, Vol.9 (10), p.8823-8835

2018

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Abstract LB-118: Identification of TRKA and TRKB kinase domain mutations that induce resistance to a pan-TRK inhibitor

Cancer research (Chicago, Ill.), 2016-07, Vol.76 (14_Supplement), p.LB-118-LB-118

2016

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Dramatic Response to Crizotinib in a Patient With Lung Cancer Positive for an HLA-DRB1-MET Gene Fusion

JCO precision oncology, 2017-01 (1), p.1-6

2017

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Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer

Resistance Mechanisms to Targeted Therapies in ROS1 + and ALK + Non-small Cell Lung Cancer

Tarloxotinib Is a Hypoxia-Activated Pan-HER Kinase Inhibitor Active Against a Broad Range of HER-Family Oncogenes

Abstract 4025: STEAP4 ISH and IHC diagnostics for Tarloxotinib activation in EGFR/HER2 mutant cancers

Amyloid precursor protein is an autonomous growth cone adhesion molecule engaged in contact guidance

ERBB family fusions are recurrent and actionable oncogenic targets across cancer types

Dosage of amyloid precursor protein affects axonal contact guidance in Down syndrome

Functional complexity of the axonal growth cone: a proteomic analysis

Dynamic adhesions and MARCKS in melanoma cells

Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding

Kv1 Potassium Channel Complexes In Vivo Require Kvβ2 Subunits in Dorsal Spinal Neurons

"When the Going Gets Tough": Novel Roles for TRPV4 in Stiffness-induced Phagolysosome Maturation

Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma

An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair

Abstract 2202: Tarloxotinib exhibits potent activity in NRG1 fusion and rearranged cancers

Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling

MEK inhibitor GSK1120212-mediated radiosensitization of pancreatic cancer cells involves inhibition of DNA double-strand break repair pathways

Abstract 6387: Therapeutic targeting of lipid oxidation and apoptosis in pancreatic ductal adenocarcinoma

Abstract C65: TRK kinase domain mutations that induce resistance to a pan-TRK inhibitor

Abstract A157: Antitumor activity of tarloxotinib, a hypoxia-activated EGFR TKI, in patient-derived lung cancer cell lines harboring EGFR exon 20 insertions

Abstract A29: The CUTO panel of patient-derived NSCLC cell lines reveals unique molecular characteristics and responses to targeted therapies

ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer

Abstract LB-118: Identification of TRKA and TRKB kinase domain mutations that induce resistance to a pan-TRK inhibitor

Dramatic Response to Crizotinib in a Patient With Lung Cancer Positive for an HLA-DRB1-MET Gene Fusion

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