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Extracellular histones increase plasma thrombin generation by impairing thrombomodulin‐dependent protein C activation

Journal of thrombosis and haemostasis, 2011-09, Vol.9 (9), p.1795-1803

2011

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Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells

Journal of thrombosis and haemostasis, 2014-10, Vol.12 (10), p.1697-1702

2014

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Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin

Journal of thrombosis and haemostasis, 2005-07, Vol.3 (7), p.1351-1359

2005

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The Ser219–>Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype

Journal of thrombosis and haemostasis, 2006-01, Vol.4 (1), p.229-235

2006

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Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor‐α converting enzyme/ADAM17

Journal of thrombosis and haemostasis, 2007-02, Vol.5 (2), p.395-402

2007

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Non‐hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia

Journal of thrombosis and haemostasis, 2007-07, Vol.5 (7), p.1394-1400

2007

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The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid

The Journal of biological chemistry, 2002-07, Vol.277 (28), p.24851-24854

2002

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Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality

The Journal of biological chemistry, 2002-11, Vol.277 (45), p.43335-43343

2002

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Metalloproteolytic Release of Endothelial Cell Protein C Receptor

The Journal of biological chemistry, 2000-02, Vol.275 (8), p.6038-6044

2000

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Tumor Necrosis Factor Leads to the Internalization and Degradation of Thrombomodulin From the Surface of Bovine Aortic Endothelial Cells in Culture

Blood, 1989-01, Vol.73 (1), p.159-165

1989

Volltextzugriff (PDF)

The protein C pathway: new insights

Thrombosis and haemostasis, 1997-07, Vol.78 (1), p.70

1997

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On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies

The Journal of clinical investigation, 1995-01, Vol.95 (1), p.309-316

1995

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Endothelial protein C receptor

Thrombosis and haemostasis, 1999-08, Vol.82 (2), p.251

1999

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Reconstitution of the Human Endothelial Cell Protein C Receptor with Thrombomodulin in Phosphatidylcholine Vesicles Enhances Protein C Activation

The Journal of biological chemistry, 1999-03, Vol.274 (10), p.6704-6710

1999

Volltextzugriff (PDF)

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation

The Journal of biological chemistry, 1991-12, Vol.266 (34), p.23016-23021

1991

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Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro

The Journal of clinical investigation, 1987, Vol.79 (1), p.124-130

1987

Volltextzugriff (PDF)

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C

The Journal of biological chemistry, 1982-01, Vol.257 (2), p.859-864

1982

Volltextzugriff (PDF)

Thrombogenic mechanisms of antiphospholipid antibodies

Thrombosis and haemostasis, 1997-07, Vol.78 (1), p.79

1997

Volltextzugriff (PDF)

The Effect of Membrane Composition on the Hemostatic Balance

Biochemistry (Easton), 1999-03, Vol.38 (12), p.3591-3598

1999

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Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis

Journal of rheumatology, 2000-02, Vol.27 (2), p.384

2000

Volltextzugriff (PDF)

Antiphospholipid Antibodies and the Protein C Pathway

Journal of autoimmunity, 2000-09, Vol.15 (2), p.221-225

2000

Volltextzugriff (PDF)

Proteolytic formation and properties of functional domains of thrombomodulin

The Journal of biological chemistry, 1987-02, Vol.262 (5), p.2206-2212

1987

Volltextzugriff (PDF)

Reconstitution of rabbit thrombomodulin into phospholipid vesicles

The Journal of biological chemistry, 1987-02, Vol.262 (5), p.2199-2205

1987

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Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation

The Journal of biological chemistry, 1982-07, Vol.257 (14), p.7944-7947

1982

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PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin

The Journal of biological chemistry, 2005-04, Vol.280 (13), p.13122-13128

2005

Volltextzugriff (PDF)

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Extracellular histones increase plasma thrombin generation by impairing thrombomodulin‐dependent protein C activation

Histones induce phosphatidylserine exposure and a procoagulant phenotype in human red blood cells

Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin

The Ser219–>Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype

Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor‐α converting enzyme/ADAM17

Non‐hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia

The Crystal Structure of the Endothelial Protein C Receptor and a Bound Phospholipid

Disruption of the Endothelial Cell Protein C Receptor Gene in Mice Causes Placental Thrombosis and Early Embryonic Lethality

Metalloproteolytic Release of Endothelial Cell Protein C Receptor

Tumor Necrosis Factor Leads to the Internalization and Degradation of Thrombomodulin From the Surface of Bovine Aortic Endothelial Cells in Culture

The protein C pathway: new insights

On the role of phosphatidylethanolamine in the inhibition of activated protein C activity by antiphospholipid antibodies

Endothelial protein C receptor

Reconstitution of the Human Endothelial Cell Protein C Receptor with Thrombomodulin in Phosphatidylcholine Vesicles Enhances Protein C Activation

The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro

Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C

Thrombogenic mechanisms of antiphospholipid antibodies

The Effect of Membrane Composition on the Hemostatic Balance

Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis

Antiphospholipid Antibodies and the Protein C Pathway

Proteolytic formation and properties of functional domains of thrombomodulin

Reconstitution of rabbit thrombomodulin into phospholipid vesicles

Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation

PAR1 Cleavage and Signaling in Response to Activated Protein C and Thrombin

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