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Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

International journal of molecular sciences, 2019-05, Vol.20 (9), p.2167

2019

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Membrane-lipid therapy: A historical perspective of membrane-targeted therapies — From lipid bilayer structure to the pathophysiological regulation of cells

Biochimica et biophysica acta. Biomembranes, 2017-09, Vol.1859 (9), p.1493-1506

Escribá, Pablo V.

2017

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The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health

Biochimica et biophysica acta, 2014-06, Vol.1838 (6), p.1518-1528

2014

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Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

Progress in lipid research, 2015-07, Vol.59, p.38-53

2015

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Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

Proceedings of the National Academy of Sciences - PNAS, 2011-12, Vol.108 (49), p.19569-19574

2011

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Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

Human molecular genetics, 2015-10, Vol.24 (20), p.5667-5676

2015

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The Antimicrobial Peptide 1018-K6 Interacts Distinctly with Eukaryotic and Bacterial Membranes, the Basis of Its Specificity and Bactericidal Activity

International journal of molecular sciences, 2022-10, Vol.23 (20), p.12392

2022

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Membrane-lipid therapy: a new approach in molecular medicine

Trends in molecular medicine, 2006, Vol.12 (1), p.34-43

Escribá, Pablo V.

2006

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Antimicrobial activity, membrane interaction and structural features of short arginine-rich antimicrobial peptides

Frontiers in microbiology, 2023-10, Vol.14, p.1244325-1244325

2023

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Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma

Biochimica et biophysica acta, 2014-06, Vol.1838 (6), p.1619

2014

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A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma

British journal of cancer, 2023-09, Vol.129 (5), p.811-818

2023

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Structural Basis of the Interaction of the G Proteins, Gαi1, Gβ1γ2 and Gαi1β1γ2, with Membrane Microdomains and Their Relationship to Cell Localization and Activity

Biomedicines, 2023-02, Vol.11 (2), p.557

2023

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Lipid–protein interactions in GPCR-associated signaling

Biochimica et biophysica acta, 2007-04, Vol.1768 (4), p.836-852

2007

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2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (22), p.8489-8494

2012

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Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging

Membranes (Basel), 2021-11, Vol.11 (12), p.944

2021

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Membrane structure and function: Relevance of lipid and protein structures in cellular physiology, pathology and therapy

Biochimica et biophysica acta, 2014-06, Vol.1838 (6), p.1449-1450

2014

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Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation

PloS one, 2017-12, Vol.12 (12), p.e0189151-e0189151

2017

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Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Biochimica et biophysica acta, 2014-06, Vol.1838 (6), p.1680-1692

2014

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Tri-2-Hydroxyarachidonein Induces Cytocidal Autophagy in Pancreatic Ductal Adenocarcinoma Cancer Cell Models

Frontiers in physiology, 2022-01, Vol.12, p.782525-782525

2022

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Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives

Biochimica et biophysica acta, 2013-11, Vol.1828 (11), p.2553-2563

2013

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HCA (2-Hydroxy-Docosahexaenoic Acid) Induces Apoptosis and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

International journal of molecular sciences, 2022-08, Vol.23 (17), p.9902

2022

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Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids

Membranes (Basel), 2021-11, Vol.11 (12), p.919

2021

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Membranes: a meeting point for lipids, proteins and therapies

Journal of cellular and molecular medicine, 2008-06, Vol.12 (3), p.829-875

2008

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The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease

Apoptosis (London), 2015-05, Vol.20 (5), p.712-724

2015

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Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues

Membrane-lipid therapy: A historical perspective of membrane-targeted therapies — From lipid bilayer structure to the pathophysiological regulation of cells

The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health

Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment

Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy

Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design

The Antimicrobial Peptide 1018-K6 Interacts Distinctly with Eukaryotic and Bacterial Membranes, the Basis of Its Specificity and Bactericidal Activity

Membrane-lipid therapy: a new approach in molecular medicine

Antimicrobial activity, membrane interaction and structural features of short arginine-rich antimicrobial peptides

Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma

A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma

Structural Basis of the Interaction of the G Proteins, Gαi1, Gβ1γ2 and Gαi1β1γ2, with Membrane Microdomains and Their Relationship to Cell Localization and Activity

Lipid–protein interactions in GPCR-associated signaling

2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy

Fundamentals of Membrane Lipid Replacement: A Natural Medicine Approach to Repairing Cellular Membranes and Reducing Fatigue, Pain, and Other Symptoms While Restoring Function in Chronic Illnesses and Aging

Membrane structure and function: Relevance of lipid and protein structures in cellular physiology, pathology and therapy

Treatment with albumin-hydroxyoleic acid complex restores sensorimotor function in rats with spinal cord injury: Efficacy and gene expression regulation

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

Tri-2-Hydroxyarachidonein Induces Cytocidal Autophagy in Pancreatic Ductal Adenocarcinoma Cancer Cell Models

Partitioning of liquid-ordered/liquid-disordered membrane microdomains induced by the fluidifying effect of 2-hydroxylated fatty acid derivatives

HCA (2-Hydroxy-Docosahexaenoic Acid) Induces Apoptosis and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells

Lipids in Pathophysiology and Development of the Membrane Lipid Therapy: New Bioactive Lipids

Membranes: a meeting point for lipids, proteins and therapies

The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer’s disease

Randomised, double-blind, placebo-controlled, parallel-group, multicentric, phase IIA clinical trial for evaluating the safety, tolerability, and therapeutic efficacy of daily oral administration of NFX88 to treat neuropathic pain in individuals with spinal cord injury

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