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Antibody Drug Conjugates for Cancer Therapy

Pharmacological reviews, 2016-01, Vol.68 (1), p.3-19

2016

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Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease

Pharmacological reviews, 2012-10, Vol.64 (4), p.972-1003

2012

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Therapeutic Potential of α 7 Nicotinic Acetylcholine Receptors

Pharmacological reviews, 2015-10, Vol.67 (4), p.1025-1073

2015

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Localization of histamine H4 receptors in the central nervous system of human and rat

Brain research, 2009-01, Vol.1250, p.41-48

2009

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Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy

Pharmacological reviews, 2013-04, Vol.65 (2), p.578-640

2013

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Cognitive Effects of MDMA in Laboratory Animals: A Systematic Review Focusing on Dose

Pharmacological reviews, 2019-07, Vol.71 (3), p.413-449

2019

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Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.176

2005

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4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

Journal of medicinal chemistry, 2005-01, Vol.48 (1), p.38-55

2005

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A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Bioorganic & medicinal chemistry letters, 2004-02, Vol.14 (3), p.689-693

2004

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Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.897

2003

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An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity

The Journal of pharmacology and experimental therapeutics, 2007-12, Vol.323 (3), p.888

2007

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Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.887

2003

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Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

Behavioural brain research, 2002-04, Vol.131 (1-2), p.151-161

2002

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α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles

The American journal of pathology, 2014-02, Vol.184 (2), p.520-529

2014

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Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-05, Vol.15 (10), p.2559-2563

2005

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Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Biochemical pharmacology, 2004-09, Vol.68 (5), p.933-945

2004

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Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

Bioorganic & medicinal chemistry letters, 2003-04, Vol.13 (7), p.1325-1328

2003

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G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations

The Journal of pharmacology and experimental therapeutics, 2005-07, Vol.314 (1), p.271

2005

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Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

Journal of medicinal chemistry, 2009-08, Vol.52 (15), p.4640-4649

2009

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In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series

Bioorganic & medicinal chemistry letters, 2008, Vol.18 (1), p.355-359

2008

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Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity

Biochemical pharmacology, 2007-04, Vol.73 (8), p.1243-1255

2007

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An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

Journal of organic chemistry, 2004-01, Vol.69 (1), p.192-194

2004

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H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Pharmacology, biochemistry and behavior, 2010-03, Vol.95 (1), p.41-50

2010

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Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

The Journal of pharmacology and experimental therapeutics, 2012-10, Vol.343 (1), p.233

2012

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Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

Journal of medicinal chemistry, 2008-10, Vol.51 (20), p.6547-6557

2008

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Biological And Medical Sciences
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Antibody Drug Conjugates for Cancer Therapy

Synthetic oleanane triterpenoids: multifunctional drugs with a broad range of applications for prevention and treatment of chronic disease

Therapeutic Potential of α 7 Nicotinic Acetylcholine Receptors

Localization of histamine H4 receptors in the central nervous system of human and rat

Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy

Cognitive Effects of MDMA in Laboratory Animals: A Systematic Review Focusing on Dose

Pharmacological properties of ABT-239 [4-(2-{2-[(2R)-2-Methylpyrrolidinyl]ethyl}-benzofuran-5-yl)benzonitrile]: II. Neurophysiological characterization and broad preclinical efficacy in cognition and schizophrenia of a potent and selective histamine H3 receptor antagonist

4-(2-[2-(2(R)-Methylpyrrolidin-1-yl)ethyl]benzofuran-5-yl)benzonitrile and Related 2-Aminoethylbenzofuran H3 Receptor Antagonists Potently Enhance Cognition and Attention

A new class of potent non-imidazole H3 antagonists: 2-aminoethylbenzofurans

Two novel and selective nonimidazole H3 receptor antagonists A-304121 and A-317920: II. In vivo behavioral and neurophysiological characterization

An 80-amino acid deletion in the third intracellular loop of a naturally occurring human histamine H3 isoform confers pharmacological differences and constitutive activity

Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

Effects of histamine H3 receptor ligands GT-2331 and ciproxifan in a repeated acquisition avoidance response in the spontaneously hypertensive rat pup

α7 Nicotinic Receptor Agonist Enhances Cognition in Aged 3xTg-AD Mice with Robust Plaques and Tangles

Structure–activity relationships of arylbenzofuran H3 receptor antagonists

Pharmacological and behavioral properties of A-349821, a selective and potent human histamine H3 receptor antagonist

Synthesis and SAR of aminoalkoxy-biaryl-4-carboxamides: Novel and selective histamine H3 receptor antagonists

G protein-dependent pharmacology of histamine H3 receptor ligands: evidence for heterogeneous active state receptor conformations

Design of a New Histamine H3 Receptor Antagonist Chemotype: (3aR,6aR)-5-Alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, Synthesis, and Structure−Activity Relationships

In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists : Trends across multiple chemical series

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity

An Efficient Multigram Synthesis of the Potent Histamine H3 Antagonist GT-2331 and the Reassessment of the Absolute Configuration

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Pharmacological properties and procognitive effects of ABT-288, a potent and selective histamine H3 receptor antagonist

Rotationally Constrained 2,4-Diamino-5,6-disubstituted Pyrimidines: A New Class of Histamine H4 Receptor Antagonists with Improved Druglikeness and in Vivo Efficacy in Pain and Inflammation Models

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