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Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8

ACS chemical biology, 2018-05, Vol.13 (5), p.1279-1290

2018

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Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms

Structure (London), 2017-01, Vol.25 (1), p.27-39

2017

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Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery

Molecular pharmaceutics, 2017-12, Vol.14 (12), p.4515-4524

2017

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Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

ACS chemical biology, 2021-11, Vol.16 (11), p.2228-2243

2021

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A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates

Biophysical journal, 2019-09, Vol.117 (5), p.844-855

2019

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Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein

Biomacromolecules, 2015-10, Vol.16 (10), p.3161-3171

2015

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The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation

Journal of inorganic biochemistry, 2017-01, Vol.166, p.26-33

2017

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The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O 2 activation

Journal of inorganic biochemistry, 2017-01, Vol.166, p.26

2017

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A Multipronged Approach for Compiling a Global Map of Allosteric Regulation in the Apoptotic Caspases

Methods in Enzymology, 2014, Vol.544, p.215-249

2014

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Phosphorylation regulates apoptotic caspase function through diverse molecular mechanisms

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms

Structure (London), 2017-01, Vol.25 (1)

2017

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CFT7455, a Novel IKZF1/3 Degrader, Demonstrates Potent Anti-Tumor Activity in Models of Non-Hodgkin's Lymphoma As a Single Agent or in Combination with Clinically Approved Agents

Blood, 2022-11, Vol.140 (Supplement 1), p.11575-11575

2022

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Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models

Cancer research (Chicago, Ill.), 2021-07, Vol.81 (13_Supplement), p.LB007-LB007

2021

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The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation

Journal of inorganic biochemistry, 2017-01, Vol.166 (C)

2017

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Phosphorylation Regulates Caspases Using Diverse Mechanisms

The FASEB journal, 2015-04, Vol.29 (S1)

2015

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Abstract ND05: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers

Cancer research (Chicago, Ill.), 2023-05, Vol.83 (7_Supplement), p.ND05-ND05

2023

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Abstract 3425: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.3425-3425

2023

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Abstract ND13: The discovery and characterization of CFT7455: A potent and selective degrader of IKZF1/3 for the treatment of relapsed/refractory multiple myeloma

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.ND13-ND13

2022

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Abstract ND09: The discovery and characterization of CFT8634: A potent and selective degrader of BRD9 for the treatment of SMARCB1-perturbed cancers

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.ND09-ND09

2022

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Abstract 2158: Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers

Cancer research (Chicago, Ill.), 2022-06, Vol.82 (12_Supplement), p.2158-2158

2022

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Development of an AchillesTAG degradation system and its application to control CAR-T activity

Current research in chemical biology, 2021, Vol.1, p.100010, Article 100010

2021

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Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel

JAMA : the journal of the American Medical Association, 2008-08, Vol.300 (5), p.555

2008

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Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel

JAMA : the journal of the American Medical Association, 2012-07, Vol.308 (4), p.387

2012

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One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 Trial

Clinical infectious diseases, 2023-10, Vol.77 (7), p.941-949

2023

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Safety and Efficacy of SAB-185 for Nonhospitalized Adults With COVID-19: A Randomized Clinical Trial

The Journal of infectious diseases, 2024-07

2024

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Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8

Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms

Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery

Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen–Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design

A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates

Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein

The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation

The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O 2 activation

A Multipronged Approach for Compiling a Global Map of Allosteric Regulation in the Apoptotic Caspases

Phosphorylation regulates apoptotic caspase function through diverse molecular mechanisms

Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms

CFT7455, a Novel IKZF1/3 Degrader, Demonstrates Potent Anti-Tumor Activity in Models of Non-Hodgkin's Lymphoma As a Single Agent or in Combination with Clinically Approved Agents

Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models

The facial triad in the α-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation

Phosphorylation Regulates Caspases Using Diverse Mechanisms

Abstract ND05: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers

Abstract 3425: The discovery and characterization of CFT1946: A potent, selective, and orally bioavailable degrader of mutant BRAF for the treatment of BRAF-driven cancers

Abstract ND13: The discovery and characterization of CFT7455: A potent and selective degrader of IKZF1/3 for the treatment of relapsed/refractory multiple myeloma

Abstract ND09: The discovery and characterization of CFT8634: A potent and selective degrader of BRD9 for the treatment of SMARCB1-perturbed cancers

Abstract 2158: Preclinical evaluation of CFT1946 as a selective degrader of mutant BRAF for the treatment of BRAF driven cancers

Development of an AchillesTAG degradation system and its application to control CAR-T activity

Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel

Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel

One Week of Oral Camostat Versus Placebo in Nonhospitalized Adults With Mild-to-Moderate Coronavirus Disease 2019: A Randomized Controlled Phase 2 Trial

Safety and Efficacy of SAB-185 for Nonhospitalized Adults With COVID-19: A Randomized Clinical Trial

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