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Consequences of Vascular Calcification

JACC. Cardiovascular imaging, 2017-10, Vol.10 (10), p.1162-1164

2017

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MB06322 (CS-917): A Potent and Selective Inhibitor of Fructose 1,6-Bisphosphatase for Controlling Gluconeogenesis in Type 2 Diabetes

Proceedings of the National Academy of Sciences - PNAS, 2005-05, Vol.102 (22), p.7970-7975

2005

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Liver-targeted drug delivery using HepDirect prodrugs

The Journal of pharmacology and experimental therapeutics, 2005-02, Vol.312 (2), p.554-560

2005

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Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

Biochemical and biophysical research communications, 2001-05, Vol.283 (2), p.417-422

2001

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Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver

Journal of the American Chemical Society, 2004-04, Vol.126 (16), p.5154-5163

2004

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Thyroid hormone β receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys

British journal of pharmacology, 2009-02, Vol.156 (3), p.454-465

2009

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Calculation of Relative Binding Free Energy Differences for Fructose 1,6-Bisphosphatase Inhibitors Using the Thermodynamic Cycle Perturbation Approach

Journal of the American Chemical Society, 2001-07, Vol.123 (26), p.6246-6252

2001

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Adenosine Kinase Inhibitors. 6. Synthesis, Water Solubility, and Antinociceptive Activity of 5-Phenyl-7-(5-deoxy-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines Substituted at C4 with Glycinamides and Related Compounds

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7808-7820

2005

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Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2883-2893

2000

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Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection

Journal of medicinal chemistry, 2007-08, Vol.50 (16), p.3891-3896

2007

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Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism

Biochemistry (Easton), 1997-09, Vol.36 (39), p.11735-11748

1997

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Computer-aided drug design strategies used in the discovery of fructose 1, 6-bisphosphatase inhibitors

Current pharmaceutical design, 2005-02, Vol.11 (3), p.283-294

2005

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Adenosine Kinase Inhibitors. 5. Synthesis, Enzyme Inhibition, and Analgesic Activity of Diaryl-erythro-furanosyltubercidin Analogues

Journal of medicinal chemistry, 2005-10, Vol.48 (20), p.6430-6441

2005

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First-in-Man Simultaneous Aortic and Mitral Valve Transcatheter Implantation Using Patient-Customized Prostheses

JACC. Case reports, 2021-04, Vol.3 (4), p.653-657

2021

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Development of a Quantum Mechanics-Based Free-Energy Perturbation Method: Use in the Calculation of Relative Solvation Free Energies

Journal of the American Chemical Society, 2004-05, Vol.126 (20), p.6224-6225

2004

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Adenosine Kinase Inhibitors. 3. Synthesis, SAR, and Antiinflammatory Activity of a Series of l-Lyxofuranosyl Nucleosides

Journal of medicinal chemistry, 2003-10, Vol.46 (22), p.4750-4760

2003

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Purine Nucleoside Phosphorylase. 1. Structure−Function Studies

Biochemistry (Easton), 1997-09, Vol.36 (39), p.11725-11734

1997

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Calculation of Relative Hydration Free Energy Differences for Heteroaromatic Compounds: Use in the Design of Adenosine Deaminase and Cytidine Deaminase Inhibitors

Journal of the American Chemical Society, 1998-04, Vol.120 (14), p.3295-3304

1998

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Efficient synthesis of purine analogues: an FeCl3–SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Tetrahedron letters, 2000-08, Vol.41 (34), p.6559-6562

2000

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Adenosine Kinase Inhibitors. 2. Synthesis, Enzyme Inhibition, and Antiseizure Activity of Diaryltubercidin Analogues

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2894-2905

2000

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Efficient Synthesis of Purines and Purine Nucleosides via an Inverse Electron Demand Diels−Alder Reaction

Journal of the American Chemical Society, 1999-06, Vol.121 (24), p.5833-5834

1999

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Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy

The Journal of pharmacology and experimental therapeutics, 1999-06, Vol.289 (3), p.1669

1999

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Stereoselective synthesis of nucleoside monophosphate HepDirect™ prodrugs

Tetrahedron letters, 2005-06, Vol.46 (25), p.4321-4324

2005

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Hypoglycaemic effect of AICAriboside in mice

Diabetologia, 1996-10, Vol.39 (10), p.1148-1155

1996

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AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

Journal of medicinal chemistry, 2001-02, Vol.44 (4), p.613-618

2001

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Consequences of Vascular Calcification

MB06322 (CS-917): A Potent and Selective Inhibitor of Fructose 1,6-Bisphosphatase for Controlling Gluconeogenesis in Type 2 Diabetes

Liver-targeted drug delivery using HepDirect prodrugs

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

Design, Synthesis, and Characterization of a Series of Cytochrome P 450 3A-Activated Prodrugs (HepDirect Prodrugs) Useful for Targeting Phosph(on)ate-Based Drugs to the Liver

Thyroid hormone β receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys

Calculation of Relative Binding Free Energy Differences for Fructose 1,6-Bisphosphatase Inhibitors Using the Thermodynamic Cycle Perturbation Approach

Adenosine Kinase Inhibitors. 6. Synthesis, Water Solubility, and Antinociceptive Activity of 5-Phenyl-7-(5-deoxy-β-d-ribofuranosyl)pyrrolo[2,3-d]pyrimidines Substituted at C4 with Glycinamides and Related Compounds

Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Liver-Targeted Prodrugs of 2‘-C-Methyladenosine for Therapy of Hepatitis C Virus Infection

Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism

Computer-aided drug design strategies used in the discovery of fructose 1, 6-bisphosphatase inhibitors

Adenosine Kinase Inhibitors. 5. Synthesis, Enzyme Inhibition, and Analgesic Activity of Diaryl-erythro-furanosyltubercidin Analogues

First-in-Man Simultaneous Aortic and Mitral Valve Transcatheter Implantation Using Patient-Customized Prostheses

Development of a Quantum Mechanics-Based Free-Energy Perturbation Method: Use in the Calculation of Relative Solvation Free Energies

Adenosine Kinase Inhibitors. 3. Synthesis, SAR, and Antiinflammatory Activity of a Series of l-Lyxofuranosyl Nucleosides

Purine Nucleoside Phosphorylase. 1. Structure−Function Studies

Calculation of Relative Hydration Free Energy Differences for Heteroaromatic Compounds: Use in the Design of Adenosine Deaminase and Cytidine Deaminase Inhibitors

Efficient synthesis of purine analogues: an FeCl3–SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Adenosine Kinase Inhibitors. 2. Synthesis, Enzyme Inhibition, and Antiseizure Activity of Diaryltubercidin Analogues

Efficient Synthesis of Purines and Purine Nucleosides via an Inverse Electron Demand Diels−Alder Reaction

Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy

Stereoselective synthesis of nucleoside monophosphate HepDirect™ prodrugs

Hypoglycaemic effect of AICAriboside in mice

AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

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