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Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat

Diabetologia, 2012-04, Vol.55 (4), p.1071-1080

2012

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Thyroid hormone β receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys

British journal of pharmacology, 2009-02, Vol.156 (3), p.454-465

2009

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Model‐Based Assessment of Plasma Citrate Flux Into the Liver: Implications for NaCT as a Therapeutic Target

CPT: pharmacometrics and systems pharmacology, 2016-03, Vol.5 (3), p.132-139

2016

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Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

Diabetologia, 2011-04, Vol.54 (4), p.935-944

2011

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Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus

Diabetes, obesity & metabolism, 2016-08, Vol.18 (8), p.795-802

2016

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Calculation of Relative Binding Free Energy Differences for Fructose 1,6-Bisphosphatase Inhibitors Using the Thermodynamic Cycle Perturbation Approach

Journal of the American Chemical Society, 2001-07, Vol.123 (26), p.6246-6252

2001

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Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2883-2893

2000

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Hypoglycaemic effect of AICAriboside in mice

Diabetologia, 1996-10, Vol.39 (10), p.1148-1155

1996

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Adenosine Kinase Inhibitors. 2. Synthesis, Enzyme Inhibition, and Antiseizure Activity of Diaryltubercidin Analogues

Journal of medicinal chemistry, 2000-07, Vol.43 (15), p.2894-2905

2000

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Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

Proceedings of the National Academy of Sciences - PNAS, 1991-12, Vol.88 (24), p.11540-11544

1991

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Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

Biochemical and biophysical research communications, 2001-05, Vol.283 (2), p.417-422

2001

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AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

Journal of medicinal chemistry, 2001-02, Vol.44 (4), p.613-618

2001

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Microbial dietary protein metabolism regulates GLP‐1 mediated intestinal transit

The FASEB journal, 2023-10, Vol.37 (10), p.e23201-n/a

2023

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AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series

Journal of medicinal chemistry, 2000-04, Vol.43 (8), p.1495-1507

2000

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AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues

Journal of medicinal chemistry, 2000-04, Vol.43 (8), p.1508-1518

2000

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N-Phosphonomethyl Dipeptides and Their Phosphonate Prodrugs, a New Generation of Neutral Endopeptidase (NEP, EC 3.4.24.11) Inhibitors

Journal of medicinal chemistry, 1994-02, Vol.37 (4), p.498-511

1994

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Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism

Biochemistry (Easton), 1997-09, Vol.36 (39), p.11735-11748

1997

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The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure

The Journal of biological chemistry, 1994-11, Vol.269 (44), p.27732-27738

1994

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Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake

Drug metabolism and disposition, 2016-10, Vol.44 (10), p.1633-1642

2016

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AMP Deaminase Inhibitors. 4. Further N3-Substituted Coformycin Aglycon Analogues: N3-Alkylmalonates as Ribose 5‘-Monophosphate Mimetics

Journal of medicinal chemistry, 2000-04, Vol.43 (8), p.1519-1524

2000

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Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

Bioorganic & medicinal chemistry letters, 1999-06, Vol.9 (11), p.1505-1510

1999

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Purine Nucleoside Phosphorylase. 1. Structure−Function Studies

Biochemistry (Easton), 1997-09, Vol.36 (39), p.11725-11734

1997

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Efficient synthesis of purine analogues: an FeCl3–SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Tetrahedron letters, 2000-08, Vol.41 (34), p.6559-6562

2000

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Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy

The Journal of pharmacology and experimental therapeutics, 1999-06, Vol.289 (3), p.1669

1999

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Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds

The Journal of pharmacology and experimental therapeutics, 1993-08, Vol.266 (2), p.707

1993

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Chronic treatment with a glucokinase activator delays the onset of hyperglycaemia and preserves beta cell mass in the Zucker diabetic fatty rat

Thyroid hormone β receptor activation has additive cholesterol lowering activity in combination with atorvastatin in rabbits, dogs and monkeys

Model‐Based Assessment of Plasma Citrate Flux Into the Liver: Implications for NaCT as a Therapeutic Target

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance

Effects of multiple ascending doses of the glucagon receptor antagonist PF-06291874 in patients with type 2 diabetes mellitus

Calculation of Relative Binding Free Energy Differences for Fructose 1,6-Bisphosphatase Inhibitors Using the Thermodynamic Cycle Perturbation Approach

Adenosine Kinase Inhibitors. 1. Synthesis, Enzyme Inhibition, and Antiseizure Activity of 5-Iodotubercidin Analogues

Hypoglycaemic effect of AICAriboside in mice

Adenosine Kinase Inhibitors. 2. Synthesis, Enzyme Inhibition, and Antiseizure Activity of Diaryltubercidin Analogues

Application of Crystallographic and Modeling Methods in the Design of Purine Nucleoside Phosphorylase Inhibitors

Isolation of a Family of Organic Anion Transporters from Human Liver and Kidney

AMP Deaminase Inhibitors. 5. Design, Synthesis, and SAR of a Highly Potent Inhibitor Series

Microbial dietary protein metabolism regulates GLP‐1 mediated intestinal transit

AMP Deaminase Inhibitors. 2. Initial Discovery of a Non-Nucleotide Transition-State Inhibitor Series

AMP Deaminase Inhibitors. 3. SAR of 3-(Carboxyarylalkyl)coformycin Aglycon Analogues

N-Phosphonomethyl Dipeptides and Their Phosphonate Prodrugs, a New Generation of Neutral Endopeptidase (NEP, EC 3.4.24.11) Inhibitors

Purine Nucleoside Phosphorylase. 2. Catalytic Mechanism

The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure

Determination of Unbound Partition Coefficient and in Vitro-in Vivo Extrapolation for SLC13A Transporter-Mediated Uptake

AMP Deaminase Inhibitors. 4. Further N3-Substituted Coformycin Aglycon Analogues: N3-Alkylmalonates as Ribose 5‘-Monophosphate Mimetics

Synthesis of phosphonate 3-phthalidyl esters as prodrugs for potential intracellular delivery of phosphonates

Purine Nucleoside Phosphorylase. 1. Structure−Function Studies

Efficient synthesis of purine analogues: an FeCl3–SiO2-promoted cyclization reaction of 4,5-diaminopyrimidines with aldehydes leading to 6,8,9-trisubstituted purines

Adenosine kinase inhibitors as a novel approach to anticonvulsant therapy

Purine nucleoside phosphorylase inhibitors: biochemical and pharmacological studies with 9-benzyl-9-deazaguanine and related compounds

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