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Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

Cell, 2017-11, Vol.171 (4), p.824-835.e18

2017

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In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

BMC biology, 2019-01, Vol.17 (1), p.4-4, Article 4

2019

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A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo

Nature communications, 2023-09, Vol.14 (1), p.5474-5474, Article 5474

2023

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Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype

EBioMedicine, 2018-03, Vol.29, p.104-111

2018

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High-resolution yeast phenomics resolves different physiological features in the saline response

Proceedings of the National Academy of Sciences - PNAS, 2003-12, Vol.100 (26), p.15724-15729

2003

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Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast

PLoS genetics, 2008-08, Vol.4 (8), p.e1000151-e1000151

2008

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APOL1 promotes endothelial cell activation beyond the glomerulus

iScience, 2023-06, Vol.26 (6), p.106830-106830, Article 106830

2023

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Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

Hepatology communications, 2022-10, Vol.6 (10), p.2689-2701

2022

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Exploring Gene Function and Drug Action Using Chemogenomic Dosage Assays

Methods in Enzymology, 2010, Vol.470, p.233-255

2010

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Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells

PLoS genetics, 2008-11, Vol.4 (11), p.e1000284-e1000284

2008

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A comprehensive platform for highly multiplexed mammalian functional genetic screens

BMC genomics, 2011-05, Vol.12 (1), p.213-213, Article 213

2011

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A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression

ACS chemical biology, 2019-03, Vol.14 (3), p.543-553

2019

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The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation

American journal of physiology: endocrinology and metabolism, 2021-04, Vol.320 (4), p.E846-E857

2021

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Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

Genome biology, 2010-03, Vol.11 (3), p.R30-R30

2010

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Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

Oncotarget, 2015-09, Vol.6 (29), p.26909-26921

2015

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A novel role of the checkpoint kinase ATR in leptin signaling

Molecular and cellular endocrinology, 2015-09, Vol.412, p.257-264

2015

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Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts

ACS chemical biology, 2017-01, Vol.12 (1), p.132-141

2017

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Abstract PR12: A genome-wide shRNA screen reveals that inhibiting kinases potentiates the anti-breast cancer activity of fluvastatin

Molecular cancer therapeutics, 2013-05, Vol.12 (5_Supplement), p.PR12-PR12

2013

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Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast: e1000151

PLoS genetics, 2008-08, Vol.4 (8)

2008

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PROPHECY--a yeast phenome database, update 2006

Nucleic acids research, 2007-01, Vol.35 (Database issue), p.D463

2007

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PROPHECY--a database for high-resolution phenomics

Nucleic acids research, 2005-01, Vol.33 (Database issue), p.D369

2005

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Genetic pleiotropy in Saccharomyces cerevisiae quantified by high-resolution phenotypic profiling

Molecular genetics and genomics : MGG, 2006-06, Vol.275 (6), p.605-614

2006

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Chemical-Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells: e1000284

PLoS genetics, 2008-11, Vol.4 (11)

2008

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Selective Inhibition of FOXO1 Activator/Repressor Balance Modulates Hepatic Glucose Handling

In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model

A Type II-B Cas9 nuclease with minimized off-targets and reduced chromosomal translocations in vivo

Therapeutic Genome Editing With CRISPR/Cas9 in a Humanized Mouse Model Ameliorates α1-antitrypsin Deficiency Phenotype

High-resolution yeast phenomics resolves different physiological features in the saline response

Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast

APOL1 promotes endothelial cell activation beyond the glomerulus

Hepatic patatin‐like phospholipase domain‐containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans

Exploring Gene Function and Drug Action Using Chemogenomic Dosage Assays

Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells

A comprehensive platform for highly multiplexed mammalian functional genetic screens

A Phenotypic Screening Approach Using Human Treg Cells Identified Regulators of Forkhead Box p3 Expression

The long noncoding RNA TUNAR modulates Wnt signaling and regulates human β-cell proliferation

Systematic analysis of genome-wide fitness data in yeast reveals novel gene function and drug action

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

A novel role of the checkpoint kinase ATR in leptin signaling

Phenotypic Screen for Cardiac Regeneration Identifies Molecules with Differential Activity in Human Epicardium-Derived Cells versus Cardiac Fibroblasts

Abstract PR12: A genome-wide shRNA screen reveals that inhibiting kinases potentiates the anti-breast cancer activity of fluvastatin

Off-Target Effects of Psychoactive Drugs Revealed by Genome-Wide Assays in Yeast: e1000151

PROPHECY--a yeast phenome database, update 2006

PROPHECY--a database for high-resolution phenomics

Genetic pleiotropy in Saccharomyces cerevisiae quantified by high-resolution phenotypic profiling

Chemical-Genetic Profiling of Imidazo[1,2-a]pyridines and -Pyrimidines Reveals Target Pathways Conserved between Yeast and Human Cells: e1000284

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