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Lessons in Molecular Recognition: The Effects of Ligand and Protein Flexibility on Molecular Docking Accuracy

Journal of medicinal chemistry, 2004-01, Vol.47 (1), p.45-55

2004

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Lessons in Molecular Recognition. 2. Assessing and Improving Cross-Docking Accuracy

Journal of chemical information and modeling, 2007-11, Vol.47 (6), p.2293-2302

2007

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A pharmacophore for human pregnane X receptor ligands

Drug metabolism and disposition, 2002-01, Vol.30 (1), p.96

2002

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Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

Bioorganic & medicinal chemistry, 2015-07, Vol.23 (13), p.3260-3268

2015

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Fragment-based design of kinase inhibitors: a practical guide

Methods in molecular biology (Clifton, N.J.), 2015, Vol.1289, p.157

Erickson, Jon A

2015

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Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Journal of medicinal chemistry, 2021-06, Vol.64 (12), p.8076-8100

2021

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Idea2Data: Toward a New Paradigm for Drug Discovery

ACS medicinal chemistry letters, 2019-03, Vol.10 (3), p.278-286

2019

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Housing The Homeless

1, 2012

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Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints

Bioorganic & medicinal chemistry, 2020-01, Vol.28 (1), p.115194, Article 115194

2020

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Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Journal of medicinal chemistry, 2016-12, Vol.59 (24), p.10974-10993

2016

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Design and synthesis of statine-containing BACE inhibitors

Bioorganic & medicinal chemistry letters, 2003-12, Vol.13 (24), p.4335-4339

2003

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Structure-guided expansion of kinase fragment libraries driven by support vector machine models

Biochimica et biophysica acta, 2010-03, Vol.1804 (3), p.642-652

2010

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Predicting the Accuracy of Ligand Overlay Methods with Random Forest Models

Journal of Chemical Information and Modeling, 2008-12, Vol.48 (12), p.2386-2394

2008

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Hydrogen Bond Donor Properties of the Difluoromethyl Group

Journal of organic chemistry, 1995-03, Vol.60 (6), p.1626-1631

1995

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Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Journal of medicinal chemistry, 2003-07, Vol.46 (14), p.3060-3071

2003

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Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1

Journal of neurochemistry, 2004-12, Vol.91 (6), p.1249-1259

2004

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Homology model directed alignment selection for comparative molecular field analysis: application to photosystem II inhibitors

Journal of computer-aided molecular design, 2000-02, Vol.14 (2), p.181-197

2000

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The Stereochemical Outcome of Electrophilic Addition Reactions on the 5,6-Double Bond in the Spinosyns

Journal of organic chemistry, 2001-12, Vol.66 (25), p.8431-8435

2001

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Theoretical Studies of Thermal Syn Elimination Reactions. The Relative Rates of Ethyl Formate, Ethyl Xanthate, and Ethyl Phosphinate Eliminations

Journal of the American Chemical Society, 1994-07, Vol.116 (14), p.6271-6276

1994

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Solid-Phase Synthesis of Novel Trimers Containing a Phenylstatine Core and Analysis by High-Resolution Magic Angle Spinning

Journal of combinatorial chemistry, 2007-09, Vol.9 (5), p.748-755

2007

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Structure-based design: finding leads in haystacks

Drug discovery today. Biosilico, 2004-09, Vol.2 (5), p.179-181

Erickson, Jon A.

2004

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Skid Row as an Urban Neighborhood, 1880-1960

Housing The Homeless, 2012, p.165-189

1, 2012

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Homeless in America

Housing The Homeless, 2012, p.3-16

1, 2012

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The Homeless of New York

Housing The Homeless, 2012, p.82-105

1, 2012

Volltextzugriff (PDF)

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Lessons in Molecular Recognition: The Effects of Ligand and Protein Flexibility on Molecular Docking Accuracy

Lessons in Molecular Recognition. 2. Assessing and Improving Cross-Docking Accuracy

A pharmacophore for human pregnane X receptor ligands

Preparation and biological evaluation of conformationally constrained BACE1 inhibitors

Fragment-based design of kinase inhibitors: a practical guide

The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans

Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor

Idea2Data: Toward a New Paradigm for Drug Discovery

Housing The Homeless

Preparation and biological evaluation of BACE1 inhibitors: Leveraging trans-cyclopropyl moieties as ligand efficient conformational constraints

Discovery of (1S,2R,3S,4S,5R,6R)‑2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity

Design and synthesis of statine-containing BACE inhibitors

Structure-guided expansion of kinase fragment libraries driven by support vector machine models

Predicting the Accuracy of Ligand Overlay Methods with Random Forest Models

Hydrogen Bond Donor Properties of the Difluoromethyl Group

Novel Potent 5-HT1F Receptor Agonists: Structure−Activity Studies of a Series of Substituted N-[3-(1-Methyl-4-piperidinyl)-1H-pyrrolo[3,2-b]pyridin-5-yl]amides

Biochemical and kinetic characterization of BACE1: investigation into the putative species‐specificity for β‐ and β′‐cleavage sites by human and murine BACE1

Homology model directed alignment selection for comparative molecular field analysis: application to photosystem II inhibitors

The Stereochemical Outcome of Electrophilic Addition Reactions on the 5,6-Double Bond in the Spinosyns

Theoretical Studies of Thermal Syn Elimination Reactions. The Relative Rates of Ethyl Formate, Ethyl Xanthate, and Ethyl Phosphinate Eliminations

Solid-Phase Synthesis of Novel Trimers Containing a Phenylstatine Core and Analysis by High-Resolution Magic Angle Spinning

Structure-based design: finding leads in haystacks

Skid Row as an Urban Neighborhood, 1880-1960

Homeless in America

The Homeless of New York

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