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Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6937-6943

2018

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Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells

Scientific reports, 2016-01, Vol.6 (1), p.18772-18772, Article 18772

2016

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Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

Biomedicine & pharmacotherapy, 2023-11, Vol.167, p.115534-115534, Article 115534

2023

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Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles

International journal of nanomedicine, 2015-01, Vol.10 (default), p.1291-1306

2015

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Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia

Neuropharmacology, 2017-10, Vol.125, p.231-242

2017

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The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain

Bioorganic chemistry, 2024-09, Vol.150, p.107537, Article 107537

2024

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Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study

Journal of neuroimmune pharmacology, 2024-08, Vol.19 (1), p.46

2024

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Soluble Epoxide Hydrolase Inhibitors: Design, Synthesis, in vitro Profiling and in vivo Evaluation in Murine Models of Pain

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors

Psychopharmacologia, 2009-07, Vol.205 (1), p.21-33

2009

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Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR

The Journal of neuroscience, 2007-12, Vol.27 (51), p.13958-13967

2007

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Antiallodynic and Analgesic Effects of Maslinic Acid, a Pentacyclic Triterpenoid from Olea europaea

Journal of natural products (Washington, D.C.), 2013-04, Vol.76 (4), p.737-740

2013

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Spinal NKCC1 Blockade Inhibits TRPV1-Dependent Referred Allodynia

Molecular pain, 2007-06, Vol.3 (1), p.17-17

2007

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Improved antitumor activity and reduced toxicity of doxorubicin encapsulated in poly(ε-caprolactone) nanoparticles in lung and breast cancer treatment: An in vitro and in vivo study

European journal of pharmaceutical sciences, 2017-05, Vol.102, p.24-34

2017

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The proof of concept of 2-{3-N-(1-benzylpiperidin-4-yl)propylamino}-6-N-methyl-N-(prop-2-yn-1-yl)amino-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain

Bioorganic chemistry, 2024-09, Vol.150, p.107537

2024

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The antinociceptive effect of morphine is reversed by okadaic acid in morphine-naive but not in morphine-tolerant mice

Pharmacology, biochemistry and behavior, 2007, Vol.86 (1), p.21-26

2007

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Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice

The journal of pain, 2012-11, Vol.13 (11), p.1107-1121

2012

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Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

Pain (Amsterdam), 2008-07, Vol.137 (3), p.520-531

2008

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Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics

Advances in experimental medicine and biology, 2017-01, Vol.964, p.109-132

2017

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Potassium channels and pain: present realities and future opportunities

European journal of pharmacology, 2004-10, Vol.500 (1), p.203-219

2004

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Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

Pain (Amsterdam), 2009-06, Vol.143 (3), p.252-261

2009

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Comparative analysis of soft-error sensitivity in LU decomposition algorithms on diverse GPUs

The Journal of supercomputing, 2024, Vol.80 (9), p.12844-12862

2024

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Evaluating the demand for carbon sequestration in olive grove soils as a strategy toward mitigating climate change

Journal of environmental management, 2012-12, Vol.112, p.368-376

2012

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Analyzing the Influence of Memory and Workload on the Reliability of GPUs Under Neutron Radiation

IEEE transactions on nuclear science, 2024-08, Vol.71 (8), p.1487-1495

2024

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Evaluating reliability through soft error triggered exceptions at ARM Cortex-A9 microprocessor

Microelectronics and reliability, 2021-11, Vol.126, p.114323, Article 114323

2021

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Contilisant, a Tetratarget Small Molecule for Alzheimer’s Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile

Low adherent cancer cell subpopulations are enriched in tumorigenic and metastatic epithelial-to-mesenchymal transition-induced cancer stem-like cells

Sigma-1 receptor agonism exacerbates immune-driven nociception: Role of TRPV1 + nociceptors

Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors

Enhanced antitumor activity of doxorubicin in breast cancer through the use of poly(butylcyanoacrylate) nanoparticles

Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia

The proof of concept of 2-{3-[N-(1-benzylpiperidin-4-yl)propyl]amino}-6-[N-methyl-N-(prop-2-yn-1-yl)amino]-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain

Sigma-1 Receptors Control Neuropathic Pain and Peripheral Neuroinflammation After Nerve Injury in Female Mice: A Transcriptomic Study

Soluble Epoxide Hydrolase Inhibitors: Design, Synthesis, in vitro Profiling and in vivo Evaluation in Murine Models of Pain

Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors

Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR

Antiallodynic and Analgesic Effects of Maslinic Acid, a Pentacyclic Triterpenoid from Olea europaea

Spinal NKCC1 Blockade Inhibits TRPV1-Dependent Referred Allodynia

Improved antitumor activity and reduced toxicity of doxorubicin encapsulated in poly(ε-caprolactone) nanoparticles in lung and breast cancer treatment: An in vitro and in vivo study

The proof of concept of 2-{3-N-(1-benzylpiperidin-4-yl)propylamino}-6-N-methyl-N-(prop-2-yn-1-yl)amino-4-phenylpyridine-3,5-dicarbonitrile for the therapy of neuropathic pain

The antinociceptive effect of morphine is reversed by okadaic acid in morphine-naive but not in morphine-tolerant mice

Role of Sigma-1 Receptors in Paclitaxel-Induced Neuropathic Pain in Mice

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics

Potassium channels and pain: present realities and future opportunities

Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

Comparative analysis of soft-error sensitivity in LU decomposition algorithms on diverse GPUs

Evaluating the demand for carbon sequestration in olive grove soils as a strategy toward mitigating climate change

Analyzing the Influence of Memory and Workload on the Reliability of GPUs Under Neutron Radiation

Evaluating reliability through soft error triggered exceptions at ARM Cortex-A9 microprocessor

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