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Deactivatable Bisubstrate Inhibitors of Protein Kinases

Molecules (Basel, Switzerland), 2022-10, Vol.27 (19), p.6689

2022

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Inhibitors and fluorescent probes for protein kinase PKAcβ and its S54L mutant, identified in a patient with cortisol producing adenoma

Bioscience, biotechnology, and biochemistry, 2020-09, Vol.84 (9), p.1839-1845

2020

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Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

ChemMedChem, 2010-01, Vol.5 (1), p.23-34

2010

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Competitive ligands facilitate dissociation of the complex of bifunctional inhibitor and protein kinase

Biophysical chemistry, 2017-09, Vol.228, p.17-24

2017

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Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

Molecules (Basel, Switzerland), 2021-07, Vol.26 (14), p.4353

2021

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Acetoxymethyl Ester of Tetrabromobenzimidazole–Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells

Bioconjugate chemistry, 2015-12, Vol.26 (12), p.2324-2335

2015

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Conjugation of Adenosine and Hexa-(d-arginine) Leads to a Nanomolar Bisubstrate-Analog Inhibitor of Basophilic Protein Kinases

Journal of medicinal chemistry, 2006-11, Vol.49 (24), p.7150-7159

2006

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Construction of Covalent Bisubstrate Inhibitor of Protein Kinase Reacting with Cysteine Residue at Substrate-Binding Site

Journal of medicinal chemistry, 2022-08, Vol.65 (16), p.10975-10991

2022

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Deoxygenation Increases Photoluminescence Lifetime of Protein-Responsive Organic Probes with Triplet–Singlet Resonant Energy Transfer

The journal of physical chemistry. B, 2016-06, Vol.120 (22), p.4945-4954

2016

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Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase

Chemical communications (Cambridge, England), 2019-09, Vol.55 (74), p.11147-1115

2019

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Correction to “Deoxygenation Increases Photoluminescence Lifetime of Protein-Responsive Organic Probes with Triplet–Singlet Resonant Energy Transfer”

The journal of physical chemistry. B, 2016-10, Vol.120 (39), p.10421-10421

2016

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Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2

Bioorganic & medicinal chemistry, 2017-04, Vol.25 (7), p.2277-2284

2017

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Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases

Biophysical chemistry, 2016-04, Vol.211, p.39-48

2016

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Intramolecular interchromophore singlet-singlet and triplet-singlet energy transfer in a metal-free donor-acceptor emitter

Journal of luminescence, 2021-09, Vol.237, p.118183, Article 118183

2021

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Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2

Bioorganic & medicinal chemistry, 2018-10, Vol.26 (18), p.5062-5068

2018

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Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase

Biochimica et biophysica acta. Proteins and proteomics, 2020-08, Vol.1868 (8), p.140427-140427, Article 140427

2020

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A Selective Biligand Inhibitor of CK2 Increases Caspase‐3 Activity in Cancer Cells and Inhibits Platelet Aggregation

ChemMedChem, 2017-10, Vol.12 (20), p.1723-1736

2017

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Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin

Chembiochem : a European journal of chemical biology, 2017-04, Vol.18 (8), p.790-798

2017

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Progesterone triggers Rho kinase-cofilin axis during in vitro and in vivo endometrial decidualization

Human reproduction (Oxford), 2021-08, Vol.36 (8), p.2230-2248

2021

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Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689

Chembiochem : a European journal of chemical biology, 2014-02, Vol.15 (3), p.443-450

2014

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Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2

Bioorganic chemistry, 2020-03, Vol.96, p.103608-103608, Article 103608

2020

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Bifunctional Ligands for Inhibition of Tight-Binding Protein–Protein Interactions

Bioconjugate chemistry, 2016-08, Vol.27 (8), p.1900-1910

2016

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Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases

Journal of peptide science, 2023-03, Vol.29 (3), p.e3456-n/a

2023

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Almost complete radiationless energy transfer from excited triplet state of a dim phosphor to a covalently linked adjacent fluorescent dye in purely organic tandem luminophores doped into PVA matrix

Journal of materials chemistry. C, Materials for optical and electronic devices, 2019, Vol.7 (22), p.6571-6577

2019

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High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

Analytical biochemistry, 2009-02, Vol.385 (1), p.85-93

2009

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Deactivatable Bisubstrate Inhibitors of Protein Kinases

Inhibitors and fluorescent probes for protein kinase PKAcβ and its S54L mutant, identified in a patient with cortisol producing adenoma

Bisubstrate Inhibitors of Protein Kinases: from Principle to Practical Applications

Competitive ligands facilitate dissociation of the complex of bifunctional inhibitor and protein kinase

Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family

Acetoxymethyl Ester of Tetrabromobenzimidazole–Peptoid Conjugate for Inhibition of Protein Kinase CK2 in Living Cells

Conjugation of Adenosine and Hexa-(d-arginine) Leads to a Nanomolar Bisubstrate-Analog Inhibitor of Basophilic Protein Kinases

Construction of Covalent Bisubstrate Inhibitor of Protein Kinase Reacting with Cysteine Residue at Substrate-Binding Site

Deoxygenation Increases Photoluminescence Lifetime of Protein-Responsive Organic Probes with Triplet–Singlet Resonant Energy Transfer

Efficient photocaging of a tight-binding bisubstrate inhibitor of cAMP-dependent protein kinase

Correction to “Deoxygenation Increases Photoluminescence Lifetime of Protein-Responsive Organic Probes with Triplet–Singlet Resonant Energy Transfer”

Oligo-aspartic acid conjugates with benzo[c][2,6]naphthyridine-8-carboxylic acid scaffold as picomolar inhibitors of CK2

Combining chemical and genetic approaches for development of responsive FRET-based sensor systems for protein kinases

Intramolecular interchromophore singlet-singlet and triplet-singlet energy transfer in a metal-free donor-acceptor emitter

Thiazole- and selenazole-comprising high-affinity inhibitors possess bright microsecond-scale photoluminescence in complex with protein kinase CK2

Discovery of strong inhibitory properties of a monoclonal antibody of PKA and use of the antibody and a competitive photoluminescent orthosteric probe for analysis of the protein kinase

A Selective Biligand Inhibitor of CK2 Increases Caspase‐3 Activity in Cancer Cells and Inhibits Platelet Aggregation

Slowly on, Slowly off: Bisubstrate‐Analogue Conjugates of 5‐Iodotubercidin and Histone H3 Peptide Targeting Protein Kinase Haspin

Progesterone triggers Rho kinase-cofilin axis during in vitro and in vivo endometrial decidualization

Long Residence Times Revealed by Aurora A Kinase-Targeting Fluorescent Probes Derived from Inhibitors MLN8237 and VX-689

Unexpected CK2β-antagonistic functionality of bisubstrate inhibitors targeting protein kinase CK2

Bifunctional Ligands for Inhibition of Tight-Binding Protein–Protein Interactions

Conjugates of adenosine mimetics and arginine‐rich peptides serve as inhibitors and fluorescent probes but not as long‐lifetime photoluminescent probes for protein arginine methyltransferases

Almost complete radiationless energy transfer from excited triplet state of a dim phosphor to a covalently linked adjacent fluorescent dye in purely organic tandem luminophores doped into PVA matrix

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

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