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Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity

Viruses, 2022-04, Vol.14 (4), p.803

2022

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Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit

Scientific reports, 2019-07, Vol.9 (1), p.1-13, Article 10826

2019

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Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)

Scientific reports, 2022-05, Vol.12 (1), p.8657-8657, Article 8657

2022

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A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15777-15788

2017

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Primate differential redoxome (PDR) – A paradigm for understanding neurodegenerative diseases

Redox biology, 2020-09, Vol.36, p.101683-101683, Article 101683

2020

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MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS

Cell death & disease, 2018-01, Vol.9 (2), p.107-14, Article 107

2018

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SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera

iScience, 2021-12, Vol.24 (12), p.103467-103467, Article 103467

2021

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Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

Journal of medicinal chemistry, 2008-02, Vol.51 (3), p.625-633

2008

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Identification of Residues Important for Agonist Recognition and Activation in GPR40

The Journal of biological chemistry, 2007-10, Vol.282 (40), p.29248-29255

2007

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Surface dynamics in allosteric regulation of protein-protein interactions: modulation of calmodulin functions by Ca2

PLoS computational biology, 2013-04, Vol.9 (4), p.e1003028-e1003028

2013

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A Virtual Screen for Diverse Ligands: Discovery of Selective G Protein-Coupled Receptor Antagonists

Journal of the American Chemical Society, 2008-04, Vol.130 (15), p.5115-5123

2008

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Thyrotropin-releasing hormone and its receptors--a hypothesis for binding and receptor activation

Pharmacology & therapeutics (Oxford), 2007-02, Vol.113 (2), p.410-419

2007

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Acetohydroxyacid synthase: A new enzyme for chiral synthesis of R-phenylacetylcarbinol

Biotechnology and bioengineering, 2003-09, Vol.83 (7), p.833-840

2003

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Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists

The Journal of biological chemistry, 2006-05, Vol.281 (19), p.13103-13109

2006

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Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties

Biochimica et biophysica acta, 2006-03, Vol.1760 (3), p.356-363

2006

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Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis

Brain (London, England : 1878), 2023-11, Vol.146 (11), p.4594-4607

2023

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The role of protein "Stability patches" in molecular recognition: A case study of the human growth hormone-receptor complex

Journal of computational chemistry, 2016-04, Vol.37 (10), p.913-919

2016

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Complementarity of stability patches at the interfaces of protein complexes: Implication for the structural organization of energetic hot spots

Proteins, structure, function, and bioinformatics, 2018-02, Vol.86 (2), p.229-236

2018

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Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain

Biophysical journal, 2016-12, Vol.111 (12), p.2620-2628

2016

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Protein Hot Spots: The Islands of Stability

Journal of molecular biology, 2012-01, Vol.415 (2), p.419-428

2012

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Superoxide Dismutase 1 (SOD1)-Derived Peptide Inhibits Amyloid Aggregation of Familial Amyotrophic Lateral Sclerosis SOD1 Mutants

ACS chemical neuroscience, 2016-11, Vol.7 (11), p.1595-1606

2016

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Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible During Misfolding

ACS chemical neuroscience, 2021-01, Vol.12 (1), p.49-62

2021

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Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer’s Disease and Neuronal Cell Death

ACS chemical neuroscience, 2019-08, Vol.10 (8), p.3555-3564

2019

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A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage

Journal of cell science, 2018-08, Vol.131 (16)

2018

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Surface dynamics in allosteric regulation of protein-protein interactions: modulation of calmodulin functions by [Ca.sup.2+]

PLoS computational biology, 2013-04, Vol.9 (4)

2013

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Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity

Cu/Zn-superoxide dismutase and wild-type like fALS SOD1 mutants produce cytotoxic quantities of H2O2 via cysteine-dependent redox short-circuit

Yeast-based directed-evolution for high-throughput structural stabilization of G protein-coupled receptors (GPCRs)

A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

Primate differential redoxome (PDR) – A paradigm for understanding neurodegenerative diseases

MIF inhibits the formation and toxicity of misfolded SOD1 amyloid aggregates: implications for familial ALS

SARS CoV-2 Delta variant exhibits enhanced infectivity and a minor decrease in neutralization sensitivity to convalescent or post-vaccination sera

Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

Identification of Residues Important for Agonist Recognition and Activation in GPR40

Surface dynamics in allosteric regulation of protein-protein interactions: modulation of calmodulin functions by Ca2

A Virtual Screen for Diverse Ligands: Discovery of Selective G Protein-Coupled Receptor Antagonists

Thyrotropin-releasing hormone and its receptors--a hypothesis for binding and receptor activation

Acetohydroxyacid synthase: A new enzyme for chiral synthesis of R-phenylacetylcarbinol

Low Affinity Analogs of Thyrotropin-releasing Hormone Are Super-agonists

Acetohydroxyacid synthase isozyme I from Escherichia coli has unique catalytic and regulatory properties

Blocking an epitope of misfolded SOD1 ameliorates disease phenotype in a model of amyotrophic lateral sclerosis

The role of protein "Stability patches" in molecular recognition: A case study of the human growth hormone-receptor complex

Complementarity of stability patches at the interfaces of protein complexes: Implication for the structural organization of energetic hot spots

Construction of Structural Mimetics of the Thyrotropin Receptor Intracellular Domain

Protein Hot Spots: The Islands of Stability

Superoxide Dismutase 1 (SOD1)-Derived Peptide Inhibits Amyloid Aggregation of Familial Amyotrophic Lateral Sclerosis SOD1 Mutants

Exposure of β6/β7-Loop in Zn/Cu Superoxide Dismutase (SOD1) Is Coupled to Metal Loss and Is Transiently Reversible During Misfolding

Interactions between BIM Protein and Beta-Amyloid May Reveal a Crucial Missing Link between Alzheimer’s Disease and Neuronal Cell Death

A predicted unstructured C-terminal loop domain in SIRT1 is required for cathepsin B cleavage

Surface dynamics in allosteric regulation of protein-protein interactions: modulation of calmodulin functions by [Ca.sup.2+]

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