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The Pharmacokinetics and Safety of Tucatinib in Volunteers with Hepatic Impairment

Clinical pharmacokinetics, 2022-12, Vol.61 (12), p.1761-1770

2022

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Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects

Journal of clinical pharmacology, 2021-04, Vol.61 (4), p.461-471

2021

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Effect of Tucatinib on Cardiac Repolarization in Healthy Volunteers

Drugs in R&D, 2023-12, Vol.23 (4), p.411-419

2023

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Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans

The Journal of nuclear medicine (1978), 2009-08, Vol.50 (8), p.1276-1282

2009

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The role of transporters in drug interactions

European journal of pharmaceutical sciences, 2006-04, Vol.27 (5), p.501-517

2006

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Brain Mu-Opioid Receptor Binding Predicts Treatment Outcome in Cocaine-Abusing Outpatients

Biological psychiatry (1969), 2010-10, Vol.68 (8), p.697-703

2010

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The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse

Biopharmaceutics & drug disposition, 2016-09, Vol.37 (6), p.336-344

2016

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The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes

The Journal of pharmacology and experimental therapeutics, 2009-04, Vol.329 (1), p.387

2009

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The role of nucleoside transporters in the erythrocyte disposition and oral absorption of ribavirin in the wild-type and equilibrative nucleoside transporter 1-/- mice

The Journal of pharmacology and experimental therapeutics, 2009-10, Vol.331 (1), p.287

2009

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Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes

American journal of physiology: Gastrointestinal and liver physiology, 2008-09, Vol.295 (3), p.G570-G580

2008

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Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy

AIDS (London), 2018-07, Vol.32 (12), p.1661-1667

2018

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Role of the Equilibrative and Concentrative Nucleoside Transporters in the Intestinal Absorption of the Nucleoside Drug, Ribavirin, in Wild-Type and Ent1(−/−) Mice

Molecular pharmaceutics, 2012-09, Vol.9 (9), p.2442-2449

2012

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Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: An agonist probe for the α7 nicotinic acetylcholine receptor

Nuclear medicine and biology, 2013-08, Vol.40 (6), p.731-739

2013

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Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography

Lupus, 2017-02, Vol.26 (2), p.170-178

2017

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Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib

Clinical pharmacology and therapeutics, 2024-02, Vol.115 (2), p.299-308

2024

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Risk‐Based Pharmacokinetic and Drug–Drug Interaction Characterization of Antibody–Drug Conjugates in Oncology Clinical Development: An International Consortium for Innovation and Quality in Pharmaceutical Development Perspective

Clinical pharmacology and therapeutics, 2022-10, Vol.112 (4), p.754-769

2022

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Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers

Clinical pharmacokinetics, 2022-10, Vol.61 (10), p.1417-1426

2022

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Population Pharmacokinetic Modeling and Exposure–Response Assessment for the Antibody‐Drug Conjugate Brentuximab Vedotin in Hodgkin's Lymphoma in the Phase III ECHELON‐1 Study

Clinical pharmacology and therapeutics, 2019-12, Vol.106 (6), p.1268-1279

2019

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Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

Cancer chemotherapy and pharmacology, 2022-06, Vol.89 (6), p.737-750

2022

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Abstract 3016: Tucatinib inhibits CYP3A, CYP2C8 and P-gp-mediated elimination and is impacted by CYP2C8 inhibition in healthy volunteers

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.3016-3016

2020

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Quantitative Prediction of Human Pharmacokinetics for Monoclonal Antibodies: Retrospective Analysis of Monkey as a Single Species for First-in-Human Prediction

Clinical pharmacokinetics, 2011-02, Vol.50 (2), p.131-142

2011

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Electrophysiological Characterization and Modeling of the Structure Activity Relationship of the Human Concentrative Nucleoside Transporter 3 (hCNT3)

Molecular pharmacology, 2006-05, Vol.69 (5), p.1542-1553

2006

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Decreased microglial activation in MS patients treated with glatiramer acetate

Journal of neurology, 2012-06, Vol.259 (6), p.1199-1205

2012

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Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV

Journal of neurovirology, 2014-06, Vol.20 (3), p.219-232

2014

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Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1

Biochemical journal, 2004-05, Vol.380 (Pt 1), p.131-137

2004

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The Pharmacokinetics and Safety of Tucatinib in Volunteers with Hepatic Impairment

Tucatinib Inhibits Renal Transporters OCT2 and MATE Without Impacting Renal Function in Healthy Subjects

Effect of Tucatinib on Cardiac Repolarization in Healthy Volunteers

Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans

The role of transporters in drug interactions

Brain Mu-Opioid Receptor Binding Predicts Treatment Outcome in Cocaine-Abusing Outpatients

The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse

The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes

The role of nucleoside transporters in the erythrocyte disposition and oral absorption of ribavirin in the wild-type and equilibrative nucleoside transporter 1-/- mice

Expression and hepatobiliary transport characteristics of the concentrative and equilibrative nucleoside transporters in sandwich-cultured human hepatocytes

Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy

Role of the Equilibrative and Concentrative Nucleoside Transporters in the Intestinal Absorption of the Nucleoside Drug, Ribavirin, in Wild-Type and Ent1(−/−) Mice

Radiochemical synthesis and in vivo evaluation of [18F]AZ11637326: An agonist probe for the α7 nicotinic acetylcholine receptor

Neuroimaging of translocator protein in patients with systemic lupus erythematosus: a pilot study using [11C]DPA-713 positron emission tomography

Creation of Novel Sensitive Probe Substrate and Moderate Inhibitor Models for a Comprehensive Prediction of CYP2C8 Interactions for Tucatinib

Risk‐Based Pharmacokinetic and Drug–Drug Interaction Characterization of Antibody–Drug Conjugates in Oncology Clinical Development: An International Consortium for Innovation and Quality in Pharmaceutical Development Perspective

Evaluation of Safety and Clinically Relevant Drug–Drug Interactions with Tucatinib in Healthy Volunteers

Population Pharmacokinetic Modeling and Exposure–Response Assessment for the Antibody‐Drug Conjugate Brentuximab Vedotin in Hodgkin's Lymphoma in the Phase III ECHELON‐1 Study

Elimination of tucatinib, a small molecule kinase inhibitor of HER2, is primarily governed by CYP2C8 enantioselective oxidation of gem-dimethyl

Abstract 3016: Tucatinib inhibits CYP3A, CYP2C8 and P-gp-mediated elimination and is impacted by CYP2C8 inhibition in healthy volunteers

Quantitative Prediction of Human Pharmacokinetics for Monoclonal Antibodies: Retrospective Analysis of Monkey as a Single Species for First-in-Human Prediction

Electrophysiological Characterization and Modeling of the Structure Activity Relationship of the Human Concentrative Nucleoside Transporter 3 (hCNT3)

Decreased microglial activation in MS patients treated with glatiramer acetate

Regional brain distribution of translocator protein using [11C]DPA-713 PET in individuals infected with HIV

Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1

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