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Structural insights into the functional diversity of the CDK–cyclin family

Open biology, 2018-09, Vol.8 (9), p.180112

2018

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The Structural Basis for Control of Eukaryotic Protein Kinases

Annual review of biochemistry, 2012-01, Vol.81 (1), p.587-613

2012

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CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Nature communications, 2015-04, Vol.6 (1), p.6769-6769, Article 6769

2015

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Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation

Cell reports (Cambridge), 2023-03, Vol.42 (3), p.112139-112139, Article 112139

2023

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FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Journal of medicinal chemistry, 2019-04, Vol.62 (7), p.3741-3752

2019

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Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Scientific reports, 2023-07, Vol.13 (1), p.10718-10718, Article 10718

2023

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Structure-based discovery of cyclin-dependent protein kinase inhibitors

Essays in biochemistry, 2017-11, Vol.61 (5), p.439

2017

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Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Cell reports (Cambridge), 2017-10, Vol.21 (5), p.1386-1398

2017

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Structural characterization of the cyclin-dependent protein kinase family

Biochemical Society transactions, 2013-08, Vol.41 (4), p.1008

2013

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Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

Journal of medicinal chemistry, 2008-02, Vol.51 (4), p.737-751

2008

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Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

Journal of medicinal chemistry, 2011-03, Vol.54 (5), p.1233-1243

2011

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The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Structure (London), 2012-10, Vol.20 (10), p.1788-1795

2012

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Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

Nature cell biology, 1999-05, Vol.1 (1), p.60-67

1999

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The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

Nature cell biology, 1999-11, Vol.1 (7), p.438-443

1999

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Chatterboxes: the structural and functional diversity of cyclins

Seminars in cell & developmental biology, 2020-11, Vol.107, p.4-20

2020

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How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A

The Journal of biological chemistry, 2007-02, Vol.282 (5), p.3173-3181

2007

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Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

The EMBO journal, 2005-09, Vol.24 (18), p.3178-3189

2005

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Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Cell chemical biology, 2019-01, Vol.26 (1), p.121-130.e5

2019

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Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Journal of the American Chemical Society, 2006-05, Vol.128 (18), p.6012-6013

2006

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Substituted 4‑(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X‑ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

Journal of medicinal chemistry, 2013-02, Vol.56 (3), p.640-659

2013

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Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

Journal of medicinal chemistry, 2017-03, Vol.60 (5), p.1746-1767

2017

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Protein Kinase Inhibitors: Insights into Drug Design from Structure

Science (American Association for the Advancement of Science), 2004-03, Vol.303 (5665), p.1800-1805

2004

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Recent developments in cyclin-dependent kinase biochemical and structural studies

Biochimica et biophysica acta, 2010-03, Vol.1804 (3), p.511-519

2010

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Emerging approaches to CDK inhibitor development, a structural perspective

RSC chemical biology, 2023-02, Vol.4 (2), p.146-164

2023

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Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions

Journal of medicinal chemistry, 2022-11, Vol.65 (22), p.15416-15432

2022

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Structural insights into the functional diversity of the CDK–cyclin family

The Structural Basis for Control of Eukaryotic Protein Kinases

CDK1 structures reveal conserved and unique features of the essential cell cycle CDK

Cyclin A and Cks1 promote kinase consensus switching to non-proline-directed CDK1 phosphorylation

FragLitesMinimal, Halogenated Fragments Displaying Pharmacophore Doublets. An Efficient Approach to Druggability Assessment and Hit Generation

Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1

Structure-based discovery of cyclin-dependent protein kinase inhibitors

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System

Structural characterization of the cyclin-dependent protein kinase family

Meriolins (3-(Pyrimidin-4-yl)-7-azaindoles): Synthesis, Kinase Inhibitory Activity, Cellular Effects, and Structure of a CDK2/Cyclin A/Meriolin Complex

Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein−Protein Interaction: Structure−Activity Studies Leading to Improved Potency

The CDK9 Tail Determines the Reaction Pathway of Positive Transcription Elongation Factor b

Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases

The structural basis for specificity of substrate and recruitment peptides for cyclin-dependent kinases

Chatterboxes: the structural and functional diversity of cyclins

How Tyrosine 15 Phosphorylation Inhibits the Activity of Cyclin-dependent Kinase 2-Cyclin A

Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain

Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Searching for Cyclin-Dependent Kinase Inhibitors Using a New Variant of the Cope Elimination

Substituted 4‑(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X‑ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK‑2 Selectivity of 6‑Substituted 2‑Arylaminopurines

Protein Kinase Inhibitors: Insights into Drug Design from Structure

Recent developments in cyclin-dependent kinase biochemical and structural studies

Emerging approaches to CDK inhibitor development, a structural perspective

Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLitesHalogenated Probes of Druglike and Peptide-like Molecular Interactions

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