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GDF15 and Growth Control

Frontiers in physiology, 2018-11, Vol.9, p.1712-1712

2018

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The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

Nature medicine, 2017-10, Vol.23 (10), p.1215-1219

2017

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The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors

PloS one, 2022-10, Vol.17 (10), p.e0275604-e0275604

2022

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The current state of GPCR‐based drug discovery to treat metabolic disease

British journal of pharmacology, 2018-11, Vol.175 (21), p.4060-4071

2018

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Glucose dysregulation and response to common anti-diabetic agents in the FATZO/Pco mouse

PloS one, 2017-06, Vol.12 (6), p.e0179856-e0179856

2017

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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

JCI insight, 2020-09, Vol.5 (17)

2020

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The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

eLife, 2020-07, Vol.9

2020

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Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

Cell metabolism, 2023-02, Vol.35 (2), p.274-286.e10

2023

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GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

Diabetes (New York, N.Y.), 2022-07, Vol.71 (7), p.1410-1423

2022

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Structural determinants of dual incretin receptor agonism by tirzepatide

Proceedings of the National Academy of Sciences - PNAS, 2022-03, Vol.119 (13), p.e2116506119-e2116506119

2022

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Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

Molecular metabolism (Germany), 2022-01, Vol.55, p.101407-101407, Article 101407

2022

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Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse

PloS one, 2017-06, Vol.12 (6), p.e0179808-e0179808

2017

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A systematic review of resilient performance in defence and security settings

PloS one, 2022-10, Vol.17 (10), p.e0273015

2022

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Identification of AgRP cells in the murine hindbrain that drive feeding

Molecular metabolism (Germany), 2024-02, Vol.80, p.101886-101886, Article 101886

2024

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A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit/hyperactivity disorder

Psychopharmacology, 2013-03, Vol.226 (2), p.189-200

2013

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Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice

Endocrinology (Philadelphia), 2017-10, Vol.158 (10), p.3090-3096

2017

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Beyond Glucagon-like Peptide-1: Is G‑Protein Coupled Receptor Polypharmacology the Path Forward to Treating Metabolic Diseases?

ACS pharmacology & translational science, 2018-09, Vol.1 (1), p.3-11

2018

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Melanocortin-4 receptor agonists for the treatment of obesity

Current topics in medicinal chemistry, 2007-06, Vol.7 (11), p.1121-1130

2007

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Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice

Journal of the Endocrine Society, 2019-07, Vol.3 (7), p.1423-1444

2019

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Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro

The Journal of physiology, 1999-06, Vol.517 (2), p.431-445

1999

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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

Journal of medicinal chemistry, 2004-01, Vol.47 (3), p.744-755

2004

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Na + modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists

European journal of pharmacology, 2004-06, Vol.494 (2), p.121-130

2004

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Galanin Receptor-Mediated Inhibition of Glutamate Release in the Arcuate Nucleus of the Hypothalamus

The Journal of neuroscience, 1998-05, Vol.18 (10), p.3489-3500

1998

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Quantifying Sleep And Physical Activity In Royal Navy Clearance Divers Using A Tri-axial Accelerometer: 920

Medicine and science in sports and exercise, 2023-09, Vol.55 (9S), p.320-320

2023

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Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2

Bioorganic & medicinal chemistry letters, 2007-12, Vol.17 (24), p.6841-6846

2007

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GDF15 and Growth Control

The metabolic effects of GDF15 are mediated by the orphan receptor GFRAL

The hypothalamic RFamide, QRFP, increases feeding and locomotor activity: The role of Gpr103 and orexin receptors

The current state of GPCR‐based drug discovery to treat metabolic disease

Glucose dysregulation and response to common anti-diabetic agents in the FATZO/Pco mouse

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

The cytokine GDF15 signals through a population of brainstem cholecystokinin neurons to mediate anorectic signalling

Discovery, development, and clinical proof of mechanism of LY3463251, a long-acting GDF15 receptor agonist

GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior

Structural determinants of dual incretin receptor agonism by tirzepatide

Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation

Correlation of disease severity with body weight and high fat diet in the FATZO/Pco mouse

A systematic review of resilient performance in defence and security settings

Identification of AgRP cells in the murine hindbrain that drive feeding

A review of the abuse potential assessment of atomoxetine: a nonstimulant medication for attention-deficit/hyperactivity disorder

Antibody-Mediated Targeting of the FGFR1c Isoform Increases Glucose Uptake in White and Brown Adipose Tissue in Male Mice

Beyond Glucagon-like Peptide-1: Is G‑Protein Coupled Receptor Polypharmacology the Path Forward to Treating Metabolic Diseases?

Melanocortin-4 receptor agonists for the treatment of obesity

Long-Acting and Selective Oxytocin Peptide Analogs Show Antidiabetic and Antiobesity Effects in Male Mice

Pre- and postsynaptic actions of opioid and orphan opioid agonists in the rat arcuate nucleus and ventromedial hypothalamus in vitro

Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor

Na + modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists

Galanin Receptor-Mediated Inhibition of Glutamate Release in the Arcuate Nucleus of the Hypothalamus

Quantifying Sleep And Physical Activity In Royal Navy Clearance Divers Using A Tri-axial Accelerometer: 920

Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2

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