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The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors

Human gene therapy, 2011-06, Vol.22 (6), p.761-774

Emery, David W

2011

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Genomic discovery of potent chromatin insulators for human gene therapy

Nature biotechnology, 2015-02, Vol.33 (2), p.198-203

2015

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Functional validation of a constitutive autonomous silencer element

PloS one, 2015-04, Vol.10 (4), p.e0124588-e0124588

2015

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Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity

PloS one, 2013-10, Vol.8 (10), p.e76528-e76528

2013

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A Chromatin Insulator Protects Retrovirus Vectors from Chromosomal Position Effects

Proceedings of the National Academy of Sciences - PNAS, 2000-08, Vol.97 (16), p.9150-9155

2000

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Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects

Human gene therapy, 2007-04, Vol.18 (4), p.333-343

2007

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Big Changes Coming To Biosafety Oversight of Clinical Gene Transfer

Molecular therapy, 2014-08, Vol.22 (8), p.1402-1402

Emery, David W

2014

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Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs

Molecular therapy, 2011-07, Vol.19 (7), p.1287-1294

2011

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Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy

Human gene therapy, 2021-10, Vol.32 (19-20), p.1186-1199

2021

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Genomic and Functional Assays Demonstrate Reduced Gammaretroviral Vector Genotoxicity Associated With Use of the cHS4 Chromatin Insulator

Molecular therapy, 2009-04, Vol.17 (4), p.716-724

2009

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Topological Constraints Governing the Use of the Chicken HS4 Chromatin Insulator in Oncoretrovirus Vectors

Molecular therapy, 2002-05, Vol.5 (5), p.589-598

2002

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In vivo selection using a cell-growth switch

Nature genetics, 2000-09, Vol.26 (1), p.64-66

2000

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Poly(ADP-ribose) Polymerase-1 (PARP-1) Contributes to the Barrier Function of a Vertebrate Chromatin Insulator

The Journal of biological chemistry, 2010-11, Vol.285 (48), p.37589-37597

2010

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A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor

Blood, 2015-02, Vol.125 (6), p.1025-1033

2015

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The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription

Cytogenetic and genome research, 2017, Vol.151 (2), p.72-81

2017

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Gene therapy for β-thalassaemia: the continuing challenge

Expert reviews in molecular medicine, 2010-10, Vol.12, p.e31-e31, Article e31

2010

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Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials

Molecular therapy, 2016-08, Vol.24 (7), p.1173-1177

2016

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Simultaneous sequence transfer into two independent locations of a reporter vector using MultiSite Gateway® Technology

BioTechniques, 2005-10, Vol.39 (4), p.553-557

2005

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Development of virus vectors for gene therapy of β chain hemoglobinopathies: flanking with a chromatin insulator reduces γ-globin gene silencing in vivo

Blood, 2002-09, Vol.100 (6), p.2012-2019

2002

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Targeted Expansion of Genetically Modified Bone Marrow Cells

Proceedings of the National Academy of Sciences - PNAS, 1998-07, Vol.95 (14), p.8093-8097

1998

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Partial correction of murine β-thalassemia with a gammaretrovirus vector for human γ-globin

Blood cells, molecules, & diseases, 2006-07, Vol.37 (1), p.1-7

2006

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Hematopoietic stem cell gene therapy

International journal of hematology, 2002-04, Vol.75 (3), p.228-236

2002

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Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites

Human gene therapy, 2012-02, Vol.23 (2), p.231-237

2012

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A functional screen for regulatory elements that improve retroviral vector gene expression

Blood cells, molecules, & diseases, 2010-12, Vol.45 (4), p.343-350

2010

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Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo

Blood cells, molecules, & diseases, 2011-08, Vol.47 (2), p.107-116

2011

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The use of chromatin insulators to improve the expression and safety of integrating gene transfer vectors

Genomic discovery of potent chromatin insulators for human gene therapy

Functional validation of a constitutive autonomous silencer element

Identification and characterization of enhancer-blocking insulators to reduce retroviral vector genotoxicity

A Chromatin Insulator Protects Retrovirus Vectors from Chromosomal Position Effects

Extended core sequences from the cHS4 insulator are necessary for protecting retroviral vectors from silencing position effects

Big Changes Coming To Biosafety Oversight of Clinical Gene Transfer

Long-term Regulation of Genetically Modified Primary Hematopoietic Cells in Dogs

Investigating the Barrier Activity of Novel, Human Enhancer-Blocking Chromatin Insulators for Hematopoietic Stem Cell Gene Therapy

Genomic and Functional Assays Demonstrate Reduced Gammaretroviral Vector Genotoxicity Associated With Use of the cHS4 Chromatin Insulator

Topological Constraints Governing the Use of the Chicken HS4 Chromatin Insulator in Oncoretrovirus Vectors

In vivo selection using a cell-growth switch

Poly(ADP-ribose) Polymerase-1 (PARP-1) Contributes to the Barrier Function of a Vertebrate Chromatin Insulator

A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor

The cHS4 Chromatin Insulator Reduces the Rate of Retroviral Vector-Mediated Gene Dysregulation Associated with Aberrant Vector Transcription

Gene therapy for β-thalassaemia: the continuing challenge

Rethinking the Regulatory Infrastructure for Human Gene Transfer Clinical Trials

Simultaneous sequence transfer into two independent locations of a reporter vector using MultiSite Gateway® Technology

Development of virus vectors for gene therapy of β chain hemoglobinopathies: flanking with a chromatin insulator reduces γ-globin gene silencing in vivo

Targeted Expansion of Genetically Modified Bone Marrow Cells

Partial correction of murine β-thalassemia with a gammaretrovirus vector for human γ-globin

Hematopoietic stem cell gene therapy

Gammaretroviral vector integration occurs overwhelmingly within and near DNase hypersensitive sites

A functional screen for regulatory elements that improve retroviral vector gene expression

Novel therapeutic candidates, identified by molecular modeling, induce γ-globin gene expression in vivo

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