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Isotope chemistry; a useful tool in the drug discovery arsenal

Bioorganic & medicinal chemistry letters, 2015-01, Vol.25 (2), p.167-171

2015

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Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

ACS nano, 2021-04, Vol.15 (4), p.6709-6722

2021

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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Angewandte Chemie (International ed.), 2020-08, Vol.59 (32), p.13490-13495

International ed. in English, 2020

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Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

Chemical research in toxicology, 2012-03, Vol.25 (3), p.532-542

2012

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Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling

Nature communications, 2024-03, Vol.15 (1), p.2592-2592, Article 2592

2024

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New trends and applications in carboxylation for isotope chemistry

Journal of labelled compounds & radiopharmaceuticals, 2018-11, Vol.61 (13), p.934-948

2018

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Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

International journal of molecular sciences, 2022-07, Vol.23 (14), p.7966

2022

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PET Tracers To Study Clinically Relevant Hepatic Transporters

Molecular pharmaceutics, 2015-07, Vol.12 (7), p.2203-2216

2015

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The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects

Journal of labelled compounds & radiopharmaceuticals, 2021-02, Vol.64 (2), p.65-72

2021

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Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists

The Journal of pharmacology and experimental therapeutics, 2015-02, Vol.352 (2), p.281

2015

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Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

Bioorganic & medicinal chemistry, 2017-02, Vol.25 (3), p.963-976

2017

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Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging

Pharmaceuticals (Basel, Switzerland), 2022-12, Vol.15 (12), p.1568

2022

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Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

Drug metabolism and disposition, 2007-04, Vol.35 (4), p.533

2007

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Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor

EJNMMI research, 2024-02, Vol.14 (1), p.19-19, Article 19

2024

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The Future of (Radio)‐Labeled Compounds in Research and Development within the Life Science Industry

Angewandte Chemie International Edition, 2023-12, Vol.62 (52), p.e202306019-n/a

International ed. in English, 2023

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Synthesis of 2 C‐14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole

Journal of labelled compounds & radiopharmaceuticals, 2017-05, Vol.60 (6), p.294-301

2017

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Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors

Nuclear medicine and biology, 2019-03, Vol.70, p.1-13

2019

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Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

EJNMMI research, 2019-11, Vol.9 (1), p.1-8, Article 100

2019

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Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1151

2012

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In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

Journal of the American Chemical Society, 2022-04, Vol.144 (15), p.6734-6741

2022

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Photochemical Strategy for Carbon Isotope Exchange with CO2

ACS catalysis, 2021-03, Vol.11 (5), p.2968-2976

2021

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Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation

Journal of the American Chemical Society, 2021-04, Vol.143 (15), p.5659-5665

2021

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Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Angewandte Chemie, 2020-08, Vol.132 (32), p.13592-13597

2020

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Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation

Angewandte Chemie International Edition, 2020-05, Vol.59 (21), p.8099-8103

International ed. in English, 2020

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Isotope chemistry; a useful tool in the drug discovery arsenal

Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Use of Radiolabeled Compounds in Drug Metabolism and Pharmacokinetic Studies

Efficient palladium-catalyzed electrocarboxylation enables late-stage carbon isotope labelling

New trends and applications in carboxylation for isotope chemistry

Differential In Vitro Effects of SGLT2 Inhibitors on Mitochondrial Oxidative Phosphorylation, Glucose Uptake and Cell Metabolism

PET Tracers To Study Clinically Relevant Hepatic Transporters

The impact of radiochemistry in drug projects: The use of C‐14 label in the AZD8529, AZD7325, and AZD6280 projects

Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists

Design, synthesis, in vitro characterization and preliminary imaging studies on fluorinated bile acid derivatives as PET tracers to study hepatic transporters

Isotopic Radiolabeling of Crizotinib with Fluorine-18 for In Vivo Pet Imaging

Pharmacokinetic Evaluation of New Drugs Using a Multi-Labelling Approach and PET Imaging: Application to a Drug Candidate with Potential Application in Neuromuscular Disorders

Metabolism and excretion of the dipeptidyl peptidase 4 inhibitor [14C]sitagliptin in humans

Synthesis and preclinical evaluation of [11C]EAI045 as a PET tracer for imaging tumors expressing mutated epidermal growth factor receptor

The Future of (Radio)‐Labeled Compounds in Research and Development within the Life Science Industry

Synthesis of 2 C‐14 labeled cathepsin C inhibitors: The use of a cyanide to displace a Benzotriazole

Synthesis and evaluation of two new candidate high-affinity full agonist PET radioligands for imaging 5-HT1B receptors

Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity

Metabolism of a G protein-coupled receptor modulator, including two major 1,2,4-oxadiazole ring-opened metabolites and a rearranged cysteine-piperazine adduct

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

Photochemical Strategy for Carbon Isotope Exchange with CO2

Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation

Transition‐Metal‐Free Carbon Isotope Exchange of Phenyl Acetic Acids

Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation

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