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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

Journal of medicinal chemistry, 2010-12, Vol.53 (24), p.8468-8484

2010

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RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis

Clinical immunology (Orlando, Fla.), 2022-11, Vol.244, p.109117-109117, Article 109117

2022

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MicroRNA-mRNA Interactions at Low Levels of Compressive Solid Stress Implicate mir-548 in Increased Glioblastoma Cell Motility

Scientific reports, 2020-01, Vol.10 (1), p.311-311, Article 311

2020

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The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu mice

Cancer Immunology, Immunotherapy, 2011-07, Vol.60 (7), p.1009-1017

2011

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Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates

Transplantation, 2005-04, Vol.79 (7), p.791

2005

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Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

Immunity (Cambridge, Mass.), 1999-02, Vol.10 (2), p.207-217

1999

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Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

Cell, 1995-07, Vol.82 (2), p.309-319

1995

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Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates

Transplantation, 2005-12, Vol.80 (12), p.1756

2005

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Development of a first-in-class autologous B cell therapy for the treatment of Fabry disease

Molecular genetics and metabolism, 2024-02, Vol.141 (2), p.107818, Article 107818

2024

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Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv

Molecular immunology, 1996-12, Vol.33 (17), p.1389-1401

1996

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Beyond Linear Elastic Modulus: Viscoelastic Models for Brain and Brain Mimetic Hydrogels

ACS biomaterials science & engineering, 2019-08, Vol.5 (8), p.3964-3973

2019

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The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu mice

Cancer Immunology, Immunotherapy, 2011-07, Vol.60 (7), p.1009-1017

2011

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Restrictive Clonal Allocation in the Chimeric Mouse Brain

Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (7), p.3374-3379

1997

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Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

Immunity (Cambridge, Mass.), 1995-09, Vol.3 (3), p.373-383

1995

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Mice deficient for the CD40 ligand

Immunity (Cambridge, Mass.), 1994-08, Vol.1 (5), p.423-431

1994

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Immune tolerance mediated by recombinant proteolipid protein prevents experimental autoimmune encephalomyelitis

Journal of neuroimmunology, 1997-10, Vol.79 (1), p.1-11

1997

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Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes

The Journal of biological chemistry, 2001-06, Vol.276 (25), p.22573-22578

2001

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The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules

The Journal of experimental medicine, 1994-02, Vol.179 (2), p.681-694

1994

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Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein

The Journal of clinical investigation, 1996-10, Vol.98 (7), p.1602-1612

1996

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The anti-tumor activity of anti-CTLA-4 is mediated through its induction of IFN gamma

Cancer Immunology, Immunotherapy, 2001-05, Vol.50 (3), p.125-133

2001

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Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2

Transplantation, 1994-06, Vol.57 (12), p.1709

1994

Volltextzugriff (PDF)

Complement inhibition with an anti-C5 monoclonal antibody prevents acute cardiac tissue injury in an ex vivo model of pig-to-human xenotransplantation

Transplantation, 1995-12, Vol.60 (11), p.1194

1995

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Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells

Molecular immunology, 1997-04, Vol.34 (6), p.441-452

1997

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Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

IgE-mediated mast cell activation promotes inflammation and cartilage destruction in osteoarthritis

RNA-seq characterization of histamine-releasing mast cells as potential therapeutic target of osteoarthritis

MicroRNA-mRNA Interactions at Low Levels of Compressive Solid Stress Implicate mir-548 in Increased Glioblastoma Cell Motility

The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu mice

Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates

Impaired Invariant Chain Degradation and Antigen Presentation and Diminished Collagen-Induced Arthritis in Cathepsin S Null Mice

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates

Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis

Development of a first-in-class autologous B cell therapy for the treatment of Fabry disease

Inhibition of complement activity by humanized anti-C5 antibody and single-chain Fv

Beyond Linear Elastic Modulus: Viscoelastic Models for Brain and Brain Mimetic Hydrogels

The CD40 agonist antibody CP-870,893 enhances dendritic cell and B-cell activity and promotes anti-tumor efficacy in SCID-hu mice

Restrictive Clonal Allocation in the Chimeric Mouse Brain

Reconstitution of invariant chain function in transgenic mice in vivo by individual p31 and p41 isoforms

Mice deficient for the CD40 ligand

Immune tolerance mediated by recombinant proteolipid protein prevents experimental autoimmune encephalomyelitis

Cathepsin S Regulates the Expression of Cathepsin L and the Turnover of γ-Interferon-inducible Lysosomal Thiol Reductase in B Lymphocytes

The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules

Treatment of experimental encephalomyelitis with a novel chimeric fusion protein of myelin basic protein and proteolipid protein

The anti-tumor activity of anti-CTLA-4 is mediated through its induction of IFN gamma

Evidence that activation of human T cells by porcine endothelium involves direct recognition of porcine SLA and costimulation by porcine ligands for LFA-1 and CD2

Complement inhibition with an anti-C5 monoclonal antibody prevents acute cardiac tissue injury in an ex vivo model of pig-to-human xenotransplantation

Humanized porcine VCAM-specific monoclonal antibodies with chimeric IgG2/G4 constant regions block human leukocyte binding to porcine endothelial cells

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