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An Updated Organ-Based Multi-Level Model for Glucose Homeostasis: Organ Distributions, Timing, and Impact of Blood Flow

Frontiers in physiology, 2021-06, Vol.12, p.619254-619254

2021

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A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo

PloS one, 2021-12, Vol.16 (12), p.e0261681-e0261681

2021

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Perturbation biology links temporal protein changes to drug responses in a melanoma cell line

PLoS computational biology, 2020-07, Vol.16 (7), p.e1007909

2020

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A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects

Diabetology and metabolic syndrome, 2023-12, Vol.15 (1), p.1-250, Article 250

2023

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A Hierarchical Whole-body Modeling Approach Elucidates the Link between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis

The Journal of biological chemistry, 2011-07, Vol.286 (29), p.26028-26041

2011

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A comprehensive mechanistic model of adipocyte signaling with layers of confidence

NPJ systems biology and applications, 2023-06, Vol.9 (1), p.24-24, Article 24

2023

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Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State

PloS one, 2015-09, Vol.10 (9), p.e0135665-e0135665

2015

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LASSIM-A network inference toolbox for genome-wide mechanistic modeling

PLoS computational biology, 2017-06, Vol.13 (6), p.e1005608-e1005608

2017

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A unified framework for prediction of liver steatosis dynamics in response to different diet and drug interventions

Clinical nutrition (Edinburgh, Scotland), 2024-06, Vol.43 (6), p.1532-1543

2024

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Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation

The Journal of biological chemistry, 2023-10, Vol.299 (10), p.105205-105205, Article 105205

2023

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Trigger factors in takotsubo syndrome – A systematic review of case reports

European journal of internal medicine, 2019-05, Vol.63, p.62-68

2019

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A multi-scale in silico mouse model for diet-induced insulin resistance

Biochemical engineering journal, 2023-02, Vol.191, p.108798, Article 108798

2023

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Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes

The Journal of biological chemistry, 2013-04, Vol.288 (14), p.9867-9880

2013

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A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes

The Journal of biological chemistry, 2021-11, Vol.297 (5), p.101221-101221, Article 101221

2021

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A Single Mechanism Can Explain Network-wide Insulin Resistance in Adipocytes from Obese Patients with Type 2 Diabetes

The Journal of biological chemistry, 2014-11, Vol.289 (48), p.33215-33230

2014

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Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes

The Journal of biological chemistry, 2016-07, Vol.291 (30), p.15806-15819

2016

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A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes

The Journal of biological chemistry, 2017-07, Vol.292 (27), p.11206-11217

2017

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Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes

Biochemical journal, 2018-05, Vol.475 (10), p.1807-1820

2018

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Insulin signaling – mathematical modeling comes of age

Trends in endocrinology and metabolism, 2012-03, Vol.23 (3), p.107-115

2012

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Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo- and endocytosis

The Journal of biological chemistry, 2017-12, Vol.292 (49), p.20032-20043

2017

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Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients

Bioscience reports, 2017-02, Vol.37 (1)

2017

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Mathematical modeling improves EC50 estimations from classical dose–response curves

The FEBS journal, 2015-03, Vol.282 (5), p.951-962

2015

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A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo

PloS one, 2021-01, Vol.16 (12), p.e0261681

2021

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Mechanisms of a Sustained Anti‐inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling

CPT: pharmacometrics and systems pharmacology, 2020-12, Vol.9 (12), p.707-717

2020

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Mathematical modeling improves EC 50 estimations from classical dose–response curves

The FEBS journal, 2015-03, Vol.282 (5), p.951-962

2015

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An Updated Organ-Based Multi-Level Model for Glucose Homeostasis: Organ Distributions, Timing, and Impact of Blood Flow

A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo

Perturbation biology links temporal protein changes to drug responses in a melanoma cell line

A multi-scale digital twin for adiposity-driven insulin resistance in humans: diet and drug effects

A Hierarchical Whole-body Modeling Approach Elucidates the Link between in Vitro Insulin Signaling and in Vivo Glucose Homeostasis

A comprehensive mechanistic model of adipocyte signaling with layers of confidence

Model-Based Quantification of the Systemic Interplay between Glucose and Fatty Acids in the Postprandial State

LASSIM-A network inference toolbox for genome-wide mechanistic modeling

A unified framework for prediction of liver steatosis dynamics in response to different diet and drug interventions

Mathematical models disentangle the role of IL-10 feedbacks in human monocytes upon proinflammatory activation

Trigger factors in takotsubo syndrome – A systematic review of case reports

A multi-scale in silico mouse model for diet-induced insulin resistance

Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes

A systems biology analysis of adrenergically stimulated adiponectin exocytosis in white adipocytes

A Single Mechanism Can Explain Network-wide Insulin Resistance in Adipocytes from Obese Patients with Type 2 Diabetes

Systems-wide Experimental and Modeling Analysis of Insulin Signaling through Forkhead Box Protein O1 (FOXO1) in Human Adipocytes, Normally and in Type 2 Diabetes

A systems biology analysis connects insulin receptor signaling with glucose transporter translocation in rat adipocytes

Inhibition of FOXO1 transcription factor in primary human adipocytes mimics the insulin-resistant state of type 2 diabetes

Insulin signaling – mathematical modeling comes of age

Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo- and endocytosis

Cross-talks via mTORC2 can explain enhanced activation in response to insulin in diabetic patients

Mathematical modeling improves EC50 estimations from classical dose–response curves

A systems biology analysis of lipolysis and fatty acid release from adipocytes in vitro and from adipose tissue in vivo

Mechanisms of a Sustained Anti‐inflammatory Drug Response in Alveolar Macrophages Unraveled with Mathematical Modeling

Mathematical modeling improves EC 50 estimations from classical dose–response curves

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