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Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

ACS medicinal chemistry letters, 2010-12, Vol.1 (9), p.472-477

2010

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Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Science (American Association for the Advancement of Science), 2011-03, Vol.331 (6023), p.1439-1443

2011

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Compound Classification Using Image‐Based Cellular Phenotypes

Measuring Biological Responses with Automated Microscopy, 2006, Vol.414, p.440-468

2006

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Peripheral neuropathy in transgenic diabetic mice: restoration of C-fiber function with human recombinant nerve growth factor

Diabetes (New York, N.Y.), 1998-10, Vol.47 (10), p.1637-1642

1998

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Growth Hormone Secretagogues: Characterization, Efficacy, and Minimal Bioactive Conformation

Proceedings of the National Academy of Sciences - PNAS, 1995-11, Vol.92 (24), p.11165-11169

1995

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Effects of oestradiol, hypothalamic extracts and luteinizing hormone releasing hormone on rat anterior pituitary gland gonadotrophin release in vitro before and after the preovulatory luteinizing hormone surge at pro-oestrus

Journal of endocrinology, 1981-09, Vol.90 (3), p.345-354

1981

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Effect of prior gonadotrophin injection on the rising phases of simulated preovulatory surges of luteinizing hormone and follicle-stimulating hormone in the plasma of phenobarbitone-blocked, pro-oestrous rats

Journal of endocrinology, 1979-12, Vol.83 (3), p.331-337

1979

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Inhibition of estrogen-induced anterior pituitary enlargement and arteriogenesis by bromocriptine in Fischer 344 rats

Endocrinology (Philadelphia), 1987-02, Vol.120 (2), p.617-621

1987

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IGF‐I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF‐I treatment

Journal of neurobiology, 1999-04, Vol.39 (1), p.142-152

1999

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Cardiac Myosin Activator CK-1316719 Increases MyoFibril ATPase Activity and Myocyte Contractility in a Rat Model of Heart Failure

Journal of cardiac failure, 2006-08, Vol.12 (6), p.S88-S88

2006

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In Vitro and In Vivo Characterization of CK-1827452, a Selective Cardiac Myosin Activator

Journal of cardiac failure, 2006-08, Vol.12 (6), p.S86-S86

2006

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In vitro characterization of four novel classes of growth hormone-releasing peptide

Endocrinology (Philadelphia), 1995-12, Vol.136 (12), p.5694-5699

1995

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Direct Arterial Vascularization of Estrogen-Induced Prolactin-Secreting Anterior Pituitary Tumors

Proceedings of the National Academy of Sciences - PNAS, 1984-07, Vol.81 (14), p.4549-4553

1984

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An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro

Pharmaceutical research, 1996, Vol.13 (1), p.23-26

1996

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Effect of Extracellular Matrix on Prolactin Secretion and mRNA Accumulation in GH 3 Cells

DNA and cell biology, 1990-06, Vol.9 (5), p.369-375

1990

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Effect of extracellular matrix on prolactin secretion and mRNA accumulation in GH3 cells

DNA and cell biology, 1990-06, Vol.9 (5), p.369

1990

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Effects of Acute Ovariectomy on Anterior Pituitary Gland Follicle-Stimulating Hormone and Luteinizing Hormone Secretion in the Metestrous Rat 1

Biology of reproduction, 1983-06, Vol.28 (5), p.1107-1113

1983

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A detailed in vitro characterization of the basal follicle-stimulating hormone and luteinizing hormone secretion rates during the rat four-day estrous cycle

Endocrinology (Philadelphia), 1981-09, Vol.109 (3), p.708-713

1981

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Ovariectomy of Young Adult Rats has a Sparing Effect on the Ability of Aged Rats to Release Luteinizing Hormone 1 , 2

Biology of reproduction, 1983-04, Vol.28 (3), p.575-585

1983

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A change in basal FSH release accompanies the onset of the second or selective phase of increased serum FSH in the cyclic rat

Life sciences (1973), 1980-03, Vol.26 (10), p.749-755

1980

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Formation of a direct arterial blood supply to the anterior pituitary gland following complete or partial interruption of the hypophyseal portal vessels

Neuroendocrinology, 1984-01, Vol.39 (3), p.251-255

1984

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Relationships Between Basal Gonadotropin Secretion Rates and Serum Gonadotropin Concentrations in Proestrous Rats1

Biology of reproduction, 1982-12, Vol.27 (5), p.1159-1168

1982

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Plasma LH Patterns after LHRH Infusion in Long-Term, Unanesthetized Ovariectomized Rats

Neuroendocrinology, 1980, Vol.30 (1), p.45-51

1980

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Dissociation between increased growth hormone and prolactin secretion during the morning hours of early pregnancy in the rat

Life sciences (1973), 1983-10, Vol.33 (15), p.1475-1478

1983

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Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide

Breast cancer research : BCR, 2014-01, Vol.16 (1), p.R7-R7, Article R7

2014

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Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Compound Classification Using Image‐Based Cellular Phenotypes

Peripheral neuropathy in transgenic diabetic mice: restoration of C-fiber function with human recombinant nerve growth factor

Growth Hormone Secretagogues: Characterization, Efficacy, and Minimal Bioactive Conformation

Effects of oestradiol, hypothalamic extracts and luteinizing hormone releasing hormone on rat anterior pituitary gland gonadotrophin release in vitro before and after the preovulatory luteinizing hormone surge at pro-oestrus

Effect of prior gonadotrophin injection on the rising phases of simulated preovulatory surges of luteinizing hormone and follicle-stimulating hormone in the plasma of phenobarbitone-blocked, pro-oestrous rats

Inhibition of estrogen-induced anterior pituitary enlargement and arteriogenesis by bromocriptine in Fischer 344 rats

IGF‐I deficient mice show reduced peripheral nerve conduction velocities and decreased axonal diameters and respond to exogenous IGF‐I treatment

Cardiac Myosin Activator CK-1316719 Increases MyoFibril ATPase Activity and Myocyte Contractility in a Rat Model of Heart Failure

In Vitro and In Vivo Characterization of CK-1827452, a Selective Cardiac Myosin Activator

In vitro characterization of four novel classes of growth hormone-releasing peptide

Direct Arterial Vascularization of Estrogen-Induced Prolactin-Secreting Anterior Pituitary Tumors

An integrated method to determine epithelial transport and bioactivity of oral drug candidates in vitro

Effect of Extracellular Matrix on Prolactin Secretion and mRNA Accumulation in GH 3 Cells

Effect of extracellular matrix on prolactin secretion and mRNA accumulation in GH3 cells

Effects of Acute Ovariectomy on Anterior Pituitary Gland Follicle-Stimulating Hormone and Luteinizing Hormone Secretion in the Metestrous Rat 1

A detailed in vitro characterization of the basal follicle-stimulating hormone and luteinizing hormone secretion rates during the rat four-day estrous cycle

Ovariectomy of Young Adult Rats has a Sparing Effect on the Ability of Aged Rats to Release Luteinizing Hormone 1 , 2

A change in basal FSH release accompanies the onset of the second or selective phase of increased serum FSH in the cyclic rat

Formation of a direct arterial blood supply to the anterior pituitary gland following complete or partial interruption of the hypophyseal portal vessels

Relationships Between Basal Gonadotropin Secretion Rates and Serum Gonadotropin Concentrations in Proestrous Rats1

Plasma LH Patterns after LHRH Infusion in Long-Term, Unanesthetized Ovariectomized Rats

Dissociation between increased growth hormone and prolactin secretion during the morning hours of early pregnancy in the rat

Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide

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