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Role of reactive metabolites in the circulation in extrahepatic toxicity

Expert opinion on drug metabolism & toxicology, 2012-09, Vol.8 (9), p.1157-1172

2012

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L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

The Journal of pharmacology and experimental therapeutics, 2008-09, Vol.326 (3), p.809

2008

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L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2252

2008

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Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.1148

2009

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S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

The Journal of pharmacology and experimental therapeutics, 2007-06, Vol.321 (3), p.1095

2007

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Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity

The Journal of pharmacology and experimental therapeutics, 2003-01, Vol.304 (1), p.185

2003

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Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes

Drug metabolism and disposition, 2008-12, Vol.36 (12), p.2468

2008

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Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

Expert opinion on drug discovery, 2018-09, Vol.13 (9), p.815-824

2018

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Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Toxicology and applied pharmacology, 2009-05, Vol.236 (3), p.358-365

2009

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Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

The Journal of pharmacology and experimental therapeutics, 2003-06, Vol.305 (3), p.1163

2003

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NREL VI rotor blade: numerical investigation and winglet design and optimization using CFD

Wind energy (Chichester, England), 2014-04, Vol.17 (4), p.605-626

2014

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Reaction of 1,2,3,4-Diepoxybutane with 2‘-Deoxyguanosine: Initial Products and Their Stabilities and Decomposition Patterns under Physiological Conditions

Chemical research in toxicology, 2005-08, Vol.18 (8), p.1316-1323

2005

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In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2036

2006

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Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Expert opinion on drug metabolism & toxicology, 2017-05, Vol.13 (5), p.513-524

2017

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Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs

Biochemical pharmacology, 2007-06, Vol.73 (11), p.1829-1841

2007

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Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Chemical research in toxicology, 2004-06, Vol.17 (6), p.819-826

2004

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Characterization of 1,2,3,4-Diepoxybutane−2‘-Deoxyguanosine Cross-Linking Products Formed at Physiological and Nonphysiological Conditions

Chemical research in toxicology, 2006-04, Vol.19 (4), p.547-555

2006

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Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Chemical research in toxicology, 2001-12, Vol.14 (12), p.1590-1595

2001

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Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen

Drug metabolism and disposition, 2004-03, Vol.32 (3), p.321

2004

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Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Toxicology (Amsterdam), 2013-04, Vol.306, p.157-161

2013

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Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Archives of biochemistry and biophysics, 1994-06, Vol.311 (2), p.342-349

1994

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Identification and Characterization of a Series of Nucleoside Adducts Formed by the Reaction of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane under Physiological Conditions

Chemical research in toxicology, 2003-12, Vol.16 (12), p.1606-1615

2003

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In vitro reactions of butadiene monoxide with single- and double-stranded DNA : Characterization and quantitation of several purine and pyrimidine adducts

Carcinogenesis (New York), 1999-02, Vol.20 (2), p.285-292

1999

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Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.77

2002

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Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

Chemical research in toxicology, 2004-04, Vol.17 (4), p.521-528

2004

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Role of reactive metabolites in the circulation in extrahepatic toxicity

L-methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination

L-methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid

Differential localization of flavin-containing monooxygenase (FMO) isoforms 1, 3, and 4 in rat liver and kidney and evidence for expression of FMO4 in mouse, rat, and human liver and kidney microsomes

S-(1,2,2-trichlorovinyl)-L-cysteine sulfoxide, a reactive metabolite of S-(1,2,2-Trichlorovinyl)-L-cysteine formed in rat liver and kidney microsomes, is a potent nephrotoxicant

Human kidney flavin-containing monooxygenases and their potential roles in cysteine s-conjugate metabolism and nephrotoxicity

Purification and characterization of flavin-containing monooxygenase isoform 3 from rat kidney microsomes

Toxicity mechanism-based prodrugs: glutathione-dependent bioactivation as a strategy for anticancer prodrug design

Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Roles of necrosis, Apoptosis, and mitochondrial dysfunction in S-(1,2-dichlorovinyl)-L-cysteine sulfoxide-induced cytotoxicity in primary cultures of human renal proximal tubular cells

NREL VI rotor blade: numerical investigation and winglet design and optimization using CFD

Reaction of 1,2,3,4-Diepoxybutane with 2‘-Deoxyguanosine: Initial Products and Their Stabilities and Decomposition Patterns under Physiological Conditions

In vivo metabolism of L-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites

Potential roles of myeloperoxidase and hypochlorous acid in metabolism and toxicity of alkene hydrocarbons and drug molecules containing olefinic moieties

Human glutathione transferases catalyzing the bioactivation of anticancer thiopurine prodrugs

Mercapturic Acid Urinary Metabolites of 3-Butene-1,2-diol as in Vivo Evidence for the Formation of Hydroxymethylvinyl Ketone in Mice and Rats

Characterization of 1,2,3,4-Diepoxybutane−2‘-Deoxyguanosine Cross-Linking Products Formed at Physiological and Nonphysiological Conditions

Hydroxymethylvinyl Ketone: A Reactive Michael Acceptor Formed by the Oxidation of 3-Butene-1,2-diol by cDNA-Expressed Human Cytochrome P450s and Mouse, Rat, and Human Liver Microsomes

Cytotoxicity of the novel glutathione-activated thiopurine prodrugs cis-AVTP [cis-6-(2-acetylvinylthio)purine] and trans-AVTG [trans-6-(2-acetylvinylthio)guanine] results from the National Cancer Institute's anticancer drug screen

Mutagenicity of the cysteine S -conjugate sulfoxides of trichloroethylene and tetrachloroethylene in the Ames test

Human Liver Microsomes Are Efficient Catalysts of 1,3-Butadiene Oxidation: Evidence for Major Roles by Cytochromes P450 2A6 and 2E1

Identification and Characterization of a Series of Nucleoside Adducts Formed by the Reaction of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane under Physiological Conditions

In vitro reactions of butadiene monoxide with single- and double-stranded DNA : Characterization and quantitation of several purine and pyrimidine adducts

Novel glutathione-dependent thiopurine prodrugs: evidence for enhanced cytotoxicity in tumor cells and for decreased bone marrow toxicity in mice

Characterization of the Reaction Products of 2‘-Deoxyguanosine and 1,2,3,4-Diepoxybutane after Acid Hydrolysis: Formation of Novel Guanine and Pyrimidine Adducts

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