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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

PloS one, 2017-07, Vol.12 (7), p.e0179431

2017

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Wnt5a–Ror–Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

Proceedings of the National Academy of Sciences - PNAS, 2012-03, Vol.109 (11), p.4044-4051

2012

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Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models

Cancer chemotherapy and pharmacology, 2014-12, Vol.74 (6), p.1125-1137

2014

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Comparative bioavailability of inhaled treprostinil administered as LIQ861 and Tyvaso® in healthy subjects

Vascular pharmacology, 2021-06, Vol.138, p.106840-106840, Article 106840

2021

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Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects

Journal of aerosol medicine and pulmonary drug delivery, 2021-08, Vol.34 (4), p.251-261

2021

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The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle

The Journal of biological chemistry, 2017-09, Vol.292 (38), p.15939-15951

2017

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Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone

Pain medicine (Malden, Mass.), 2018-02, Vol.19 (2), p.307-318

2018

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Clinical pharmacokinetics and pharmacodynamics of inhaled insulin

Clinical pharmacokinetics, 2004-01, Vol.43 (12), p.781-801

2004

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NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer

BMC cancer, 2015-10, Vol.15 (1), p.685-685, Article 685

2015

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Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration

Cancer chemotherapy and pharmacology, 2017-01, Vol.79 (1), p.57-67

2017

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Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors

Cancer chemotherapy and pharmacology, 2018-05, Vol.81 (5), p.897-909

2018

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Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study

Pain medicine (Malden, Mass.), 2020-02, Vol.21 (2), p.e114-e126

2020

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EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding

Proceedings of the National Academy of Sciences - PNAS, 2014-02, Vol.111 (6), p.2188-2193

2014

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A Multicenter, Phase I, Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Etirinotecan Pegol in Patients with Refractory Solid Tumors

Clinical cancer research, 2013-01, Vol.19 (1), p.268-278

2013

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Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study

Clinical pharmacology in drug development, 2015-11, Vol.4 (6), p.434-441

2015

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Pharmacokinetics and tolerability of amikacin administered as BAY41-6551 aerosol in mechanically ventilated patients with gram-negative pneumonia and acute renal failure

Journal of aerosol medicine and pulmonary drug delivery, 2011-08, Vol.24 (4), p.183-190

2011

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A phase 2, randomized, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of pentosan polysulfate sodium in treating subjects with mucopolysaccharidosis VI: Study update

Molecular genetics and metabolism, 2024-02, Vol.141 (2), p.107846, Article 107846

2024

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Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol

Clinical pharmacology in drug development, 2015-11, Vol.4 (6), p.442-448

2015

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Pharmacologic Profile of Naloxegol, a Peripherally Acting µ -Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation

The Journal of pharmacology and experimental therapeutics, 2017-05, Vol.361 (2), p.280-291

2017

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Pharmacokinetics and tolerability of BAY41-6551 in subjects with chronic kidney disease

Journal of aerosol medicine and pulmonary drug delivery, 2011-08, Vol.24 (4), p.191-199

2011

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A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

Pain (Amsterdam), 2013-09, Vol.154 (9), p.1542-1550

2013

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SAFETY AND PHARMACOKINETICS OF VARDENAFIL INHALATION POWDER (RT234) FOLLOWING ORAL INHALATION IN HEALTHY ADULT VOLUNTEERS

Chest, 2020-10, Vol.158 (4), p.A2212-A2212

2020

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A double-blind placebo-controlled phase 2 study to evaluate the safety and tolerability of pentosan polysulfate sodium in subjects with mucopolysaccharidosis type VI (MPS VI)

Molecular genetics and metabolism, 2022-02, Vol.135 (2), p.S47-S47

2022

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A phase 2, randomized, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of pentosan polysulfate sodium in treating subjects with mucopolysaccharidosis type VI: Study update

Molecular genetics and metabolism, 2023-02, Vol.138 (2), p.107119, Article 107119

2023

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

Proceedings of the National Academy of Sciences - PNAS, 2010-08, Vol.107 (32), p.14164-14169

2010

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Modeling the receptor pharmacology, pharmacokinetics, and pharmacodynamics of NKTR-214, a kinetically-controlled interleukin-2 (IL2) receptor agonist for cancer immunotherapy

Wnt5a–Ror–Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis

Nonclinical pharmacokinetics and activity of etirinotecan pegol (NKTR-102), a long-acting topoisomerase 1 inhibitor, in multiple cancer models

Comparative bioavailability of inhaled treprostinil administered as LIQ861 and Tyvaso® in healthy subjects

Safety, Tolerability, and Pharmacokinetics of RT234 (Vardenafil Inhalation Powder): A First-in-Human, Ascending Single- and Multiple-Dose Study in Healthy Subjects

The Ror1 receptor tyrosine kinase plays a critical role in regulating satellite cell proliferation during regeneration of injured muscle

Human Abuse Potential of the New Opioid Analgesic Molecule NKTR-181 Compared with Oxycodone

Clinical pharmacokinetics and pharmacodynamics of inhaled insulin

NKTR-102 Efficacy versus irinotecan in a mouse model of brain metastases of breast cancer

Etirinotecan pegol administration is associated with lower incidences of neutropenia compared to irinotecan administration

Integrated population pharmacokinetics of etirinotecan pegol and its four metabolites in cancer patients with solid tumors

Human Abuse Potential of Oral NKTR-181 in Recreational Opioid Users: A Randomized, Double-Blind, Crossover Study

EphB receptor forward signaling regulates area-specific reciprocal thalamic and cortical axon pathfinding

A Multicenter, Phase I, Dose-Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of Etirinotecan Pegol in Patients with Refractory Solid Tumors

Safety, tolerability, pharmacokinetics, and pharmacodynamic effects of naloxegol at peripheral and central nervous system receptors in healthy male subjects: A single ascending-dose study

Pharmacokinetics and tolerability of amikacin administered as BAY41-6551 aerosol in mechanically ventilated patients with gram-negative pneumonia and acute renal failure

A phase 2, randomized, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of pentosan polysulfate sodium in treating subjects with mucopolysaccharidosis VI: Study update

Safety, tolerability, and pharmacokinetics of multiple ascending doses of naloxegol

Pharmacologic Profile of Naloxegol, a Peripherally Acting µ -Opioid Receptor Antagonist, for the Treatment of Opioid-Induced Constipation

Pharmacokinetics and tolerability of BAY41-6551 in subjects with chronic kidney disease

A phase 2, double-blind, randomized, placebo-controlled, dose-escalation study to evaluate the efficacy, safety, and tolerability of naloxegol in patients with opioid-induced constipation

SAFETY AND PHARMACOKINETICS OF VARDENAFIL INHALATION POWDER (RT234) FOLLOWING ORAL INHALATION IN HEALTHY ADULT VOLUNTEERS

A double-blind placebo-controlled phase 2 study to evaluate the safety and tolerability of pentosan polysulfate sodium in subjects with mucopolysaccharidosis type VI (MPS VI)

A phase 2, randomized, double-blind, placebo-controlled, multicentre study to evaluate the efficacy and safety of pentosan polysulfate sodium in treating subjects with mucopolysaccharidosis type VI: Study update

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

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