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Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo

The Journal of pharmacology and experimental therapeutics, 2009-06, Vol.329 (3), p.908-918

2009

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Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats

Environmental and molecular mutagenesis, 2015-08, Vol.56 (7), p.621-628

2015

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Incidence of Spontaneous Non-Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic Mice

Toxicologic pathology, 2013-12, Vol.41 (8), p.1137-1145

2013

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Toxicity and biodistribution of the serotype 2 recombinant adeno-associated viral vector, encoding Aquaporin-1, after retroductal delivery to a single mouse parotid gland

PloS one, 2014-03, Vol.9 (3), p.e92832

2014

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Regulation of CYP1A1 by heavy metals and consequences for drug metabolism

Expert opinion on drug metabolism & toxicology, 2009-05, Vol.5 (5), p.501-521

2009

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A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats

Environmental and molecular mutagenesis, 2015-08, Vol.56 (7), p.629-636

2015

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Cytochrome P450 enzymes: central players in cardiovascular health and disease

Pharmacology & therapeutics (Oxford), 2006-11, Vol.112 (2), p.564-587

2006

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A Proposal for New Strategies in Dose Selection for 26-Week Tg.Rash2 Carcinogenicity Studies

International journal of toxicology, 2021-07, Vol.40 (4), p.311-321

2021

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The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As, Cd, and Cr

Free radical biology & medicine, 2005-12, Vol.39 (11), p.1499-1511

2005

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A Comparison of Spontaneous Tumors in Tg.rasH2 Mice in 26-week Carcinogenicity Studies Conducted at a Single Test Facility during 2004 to 2012 and 2013 to 2018

Toxicologic pathology, 2019-01, Vol.47 (1), p.18-25

2019

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Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy

Mutation research. Genetic toxicology and environmental mutagenesis, 2015-08, Vol.789-790 (C), p.61-66

2015

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The 26-Week Tg.Rash2 Mice Carcinogenicity Studies: Microscopic Examination of Only Select Tissues in Low- and Mid-dose Groups

Toxicologic pathology, 2014-10, Vol.42 (7), p.1153-1157

2014

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Regulatory Forum Opinion Piece: Retrospective Evaluation of Doses in the 26-week Tg.rasH2 Mice Carcinogenicity Studies: Recommendation to Eliminate High Doses at Maximum Tolerated Dose (MTD) in Future Studies

Toxicologic pathology, 2015-07, Vol.43 (5), p.611-620

2015

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Regulatory Forum Opinion Piece: Retrospective Evaluation of Doses in the 26-week Tg.rasH2 Mice Carcinogenicity Studies: Recommendation to Eliminate High Doses at Maximum Tolerated Dose in Future Studies. A Response to the Counterpoints

Toxicologic pathology, 2016-01, Vol.44 (1), p.5-8

2016

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Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium

Toxicology letters, 2007-08, Vol.172 (3), p.106-119

2007

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Tg.rasH2 Mice and not CByB6F1 Mice Should Be Used for 28-Day Dose Range Finding Studies Prior to 26-Week Tg.rasH2 Carcinogenicity Studies

International journal of toxicology, 2017-07, Vol.36 (4), p.287-292

2017

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Relationship of Body Weight Parameters with the Incidence of Common Spontaneous Tumors in Tg.rasH2 Mice

Toxicologic pathology, 2014-10, Vol.42 (7), p.1143-1152

2014

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The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes

Current drug metabolism, 2004-04, Vol.5 (2), p.157-167

2004

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Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium

Toxicology (Amsterdam), 2004-10, Vol.202 (3), p.249-269

2004

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Trend Analysis of Body Weight Parameters, Mortality, and Incidence of Spontaneous Tumors in Tg.rasH2 Mice

International journal of toxicology, 2014-11, Vol.33 (6), p.475-481

2014

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Renal Tumors in 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Toxicologic pathology, 2016-07, Vol.44 (5), p.633-635

2016

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Progression of Serosal Vascular Proliferative Lesions to Hemangiosarcomas in the Uterus of the 26-Week Tg.rasH2 Mice Carcinogenicity Studies

International journal of toxicology, 2017-01, Vol.36 (1), p.29-34

2017

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Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway

Free radical research, 2004-11, Vol.38 (11), p.1191-1200

2004

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Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+)

Cancer letters, 2007-02, Vol.246 (1-2), p.54

2007

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MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells

Toxicology letters, 2008-11, Vol.182 (1), p.121-126

2008

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Selective inhibitors of CYP2J2 related to terfenadine exhibit strong activity against human cancers in vitro and in vivo

Assessment of the mutagenic potential of Cr(VI) in the oral mucosa of Big Blue® transgenic F344 rats

Incidence of Spontaneous Non-Neoplastic Lesions in Transgenic CBYB6F1-Tg(HRAS)2Jic Mice

Toxicity and biodistribution of the serotype 2 recombinant adeno-associated viral vector, encoding Aquaporin-1, after retroductal delivery to a single mouse parotid gland

Regulation of CYP1A1 by heavy metals and consequences for drug metabolism

A robust method for assessing chemically induced mutagenic effects in the oral cavity of transgenic Big Blue® rats

Cytochrome P450 enzymes: central players in cardiovascular health and disease

A Proposal for New Strategies in Dose Selection for 26-Week Tg.Rash2 Carcinogenicity Studies

The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As, Cd, and Cr

A Comparison of Spontaneous Tumors in Tg.rasH2 Mice in 26-week Carcinogenicity Studies Conducted at a Single Test Facility during 2004 to 2012 and 2013 to 2018

Duodenal crypt health following exposure to Cr(VI): Micronucleus scoring, γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy

The 26-Week Tg.Rash2 Mice Carcinogenicity Studies: Microscopic Examination of Only Select Tissues in Low- and Mid-dose Groups

Regulatory Forum Opinion Piece: Retrospective Evaluation of Doses in the 26-week Tg.rasH2 Mice Carcinogenicity Studies: Recommendation to Eliminate High Doses at Maximum Tolerated Dose (MTD) in Future Studies

Regulatory Forum Opinion Piece: Retrospective Evaluation of Doses in the 26-week Tg.rasH2 Mice Carcinogenicity Studies: Recommendation to Eliminate High Doses at Maximum Tolerated Dose in Future Studies. A Response to the Counterpoints

Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium

Tg.rasH2 Mice and not CByB6F1 Mice Should Be Used for 28-Day Dose Range Finding Studies Prior to 26-Week Tg.rasH2 Carcinogenicity Studies

Relationship of Body Weight Parameters with the Incidence of Common Spontaneous Tumors in Tg.rasH2 Mice

The effect of liver cirrhosis on the regulation and expression of drug metabolizing enzymes

Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium

Trend Analysis of Body Weight Parameters, Mortality, and Incidence of Spontaneous Tumors in Tg.rasH2 Mice

Renal Tumors in 26-Week Tg.Rash2 Mice Carcinogenicity Studies

Progression of Serosal Vascular Proliferative Lesions to Hemangiosarcomas in the Uterus of the 26-Week Tg.rasH2 Mice Carcinogenicity Studies

Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway

Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+)

MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells

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