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Novel hydrazone‐isatin derivatives as potential EGFR inhibitors: Synthesis and in vitro pharmacological profiling

Archiv der Pharmazie (Weinheim), 2023-09, Vol.356 (9), p.e2300244-n/a

2023

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Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

Journal of enzyme inhibition and medicinal chemistry, 2018-01, Vol.33 (1), p.1095-1107

2018

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Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.308-319

2021

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Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

European journal of medicinal chemistry, 2019-01, Vol.162, p.147-160

2019

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New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation

Bioorganic chemistry, 2023-12, Vol.141, p.106924-106924, Article 106924

2023

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Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Drug delivery, 2022-12, Vol.29 (1), p.1100-1111

2022

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Anti-inflammatory screening and molecular modeling of some novel coumarin derivatives

Molecules (Basel, Switzerland), 2015-03, Vol.20 (4), p.5374-5391

2015

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Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

Journal of enzyme inhibition and medicinal chemistry, 2022-12, Vol.37 (1), p.1587-1599

2022

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Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.1423-1434

2021

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Synthesis and Evaluation of Some Dibromoquinazoline-sulphonamide Hybrids and some Schiff´s Base Analogs for their Cytotoxic Activity

Anti-cancer agents in medicinal chemistry, 2017-11, Vol.17 (11), p.1563

2017

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Novel N -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

Journal of enzyme inhibition and medicinal chemistry, 2023-12, Vol.38 (1), p.2278022-2278022

2023

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Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

Journal of enzyme inhibition and medicinal chemistry, 2021-01, Vol.36 (1), p.320-329

2021

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Synthesis, In-vivo and In-vitro Anti-inflammatory Evaluation of some Novel Coumarin Derivatives

Anti-inflammatory & anti-allergy agents in medicinal chemistry, 2018, Vol.17 (2), p.115-124

2018

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Evidence Based Evaluation of Pharmacological Activity and Herb-Herb interaction of Organic Extracts of Certain Natural Anti- Diabetic Mixtures

Pharmacognosy journal, 2021-12, Vol.13 (6), p.1366-1376

2021

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Salmeterol Xinafoate

Profiles of drug substances, excipients, and related methodology, 2015, Vol.40, p.321-369

2015

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Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells

European journal of medicinal chemistry, 2020-03, Vol.190, p.112112, Article 112112

2020

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Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations

Bioorganic chemistry, 2021-05, Vol.110, p.104748-104748, Article 104748

2021

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3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies

European journal of medicinal chemistry, 2020-12, Vol.207, p.112745, Article 112745

2020

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2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling

European journal of medicinal chemistry, 2023-10, Vol.258, p.115610-115610, Article 115610

2023

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An overview of synthetic approaches and the potential bioactivity of different 1,2,3-triazole hybrids

Egyptian pharmaceutical journal, 2024-04, Vol.23 (2), p.157-183

2024

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Antitumor Potential and Possible Targets of Phenothiazine Derivatives: A Recent Review

Egyptian Journal of Chemistry, 2023-12

2023

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In Silico ADME Prediction and Molecular Docking of 1,2,3-Triazole-based Compounds Against Human Aromatase Cytochrome P450

Journal of advanced pharmacy research, 2023-10, Vol.7 (4), p.232-242

2023

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Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies

Bioorganic chemistry, 2021-01, Vol.106, p.104473-104473, Article 104473

2021

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Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

Journal of enzyme inhibition and medicinal chemistry, 2021-12, Vol.36 (1), p.319-328

2021

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3-Substituted-2,3-Dihydrothiazole as a promising scaffold to design EGFR inhibitors

Bioorganic chemistry, 2022-12, Vol.129, p.106172, Article 106172

2022

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Novel hydrazone‐isatin derivatives as potential EGFR inhibitors: Synthesis and in vitro pharmacological profiling

Novel coumarin-6-sulfonamides as apoptotic anti-proliferative agents: synthesis, in vitro biological evaluation, and QSAR studies

Novel piperazine-chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation

Enhancement of the tail hydrophobic interactions within the carbonic anhydrase IX active site via structural extension: Design and synthesis of novel N-substituted isatins-SLC-0111 hybrids as carbonic anhydrase inhibitors and antitumor agents

New phenothiazine conjugates as apoptosis inducing agents: Design, synthesis, In-vitro anti-cancer screening and 131I-radiolabeling for in-vivo evaluation

Fenticonazole nitrate loaded trans-novasomes for effective management of tinea corporis: design characterization, in silico study, and exploratory clinical appraisal

Anti-inflammatory screening and molecular modeling of some novel coumarin derivatives

Design, synthesis, molecular modeling and biological evaluation of novel Benzoxazole-Benzamide conjugates via a 2-Thioacetamido linker as potential anti-proliferative agents, VEGFR-2 inhibitors and apoptotic inducers

Development of novel benzofuran-isatin conjugates as potential antiproliferative agents with apoptosis inducing mechanism in Colon cancer

Synthesis and Evaluation of Some Dibromoquinazoline-sulphonamide Hybrids and some Schiff´s Base Analogs for their Cytotoxic Activity

Novel N -Arylmethyl-aniline/chalcone hybrids as potential VEGFR inhibitors: synthesis, biological evaluations, and molecular dynamic simulations

Development of 2-oxindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

Synthesis, In-vivo and In-vitro Anti-inflammatory Evaluation of some Novel Coumarin Derivatives

Evidence Based Evaluation of Pharmacological Activity and Herb-Herb interaction of Organic Extracts of Certain Natural Anti- Diabetic Mixtures

Salmeterol Xinafoate

Inclusion of a 5-fluorouracil moiety in nitrogenous bases derivatives as human carbonic anhydrase IX and XII inhibitors produced a targeted action against MDA-MB-231 and T47D breast cancer cells

Development of isatin-thiazolo[3,2-a]benzimidazole hybrids as novel CDK2 inhibitors with potent in vitro apoptotic anti-proliferative activity: Synthesis, biological and molecular dynamics investigations

3-Methylthiazolo[3,2-a]benzimidazole-benzenesulfonamide conjugates as novel carbonic anhydrase inhibitors endowed with anticancer activity: Design, synthesis, biological and molecular modeling studies

2,4-Diaryl-pyrimido[1,2-a]benzimidazole derivatives as novel anticancer agents endowed with potent anti-leukemia activity: Synthesis, biological evaluation and kinase profiling

An overview of synthetic approaches and the potential bioactivity of different 1,2,3-triazole hybrids

Antitumor Potential and Possible Targets of Phenothiazine Derivatives: A Recent Review

In Silico ADME Prediction and Molecular Docking of 1,2,3-Triazole-based Compounds Against Human Aromatase Cytochrome P450

Development of pyridazine derivatives as potential EGFR inhibitors and apoptosis inducers: Design, synthesis, anticancer evaluation, and molecular modeling studies

Development of 2-oindolin-3-ylidene-indole-3-carbohydrazide derivatives as novel apoptotic and anti-proliferative agents towards colorectal cancer cells

3-Substituted-2,3-Dihydrothiazole as a promising scaffold to design EGFR inhibitors

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