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Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models

Journal of clinical pharmacology, 2016-07, Vol.56 (S7), p.S99-S109

2016

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Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

Pharmaceutical research, 2015-12, Vol.32 (12), p.3785-3802

2015

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In situ evaluation of the impact of metformin or verapamil coadministration with vildagliptin on its regional absorption from the rabbit’s intestine

Biopharmaceutics & drug disposition, 2024-04, Vol.45 (2), p.71-82

2024

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Targeting intestinal transporters for optimizing oral drug absorption

Current drug metabolism, 2010-11, Vol.11 (9), p.730-742

2010

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Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

1, 2017

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Navigating Transporter Sciences in Pharmacokinetics Characterization Using Extended Clearance Classification System (ECCS)

Drug metabolism and disposition, 2018-05, Vol.46 (5), p.729-739

2018

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Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

Pharmaceutical research, 2013-04, Vol.30 (4), p.1188-1199

2013

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Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System

Pharmaceutical research, 2016-12, Vol.33 (12), p.3021-3030

2016

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Development of a new permeability assay using low‐efflux MDCKII cells

Journal of pharmaceutical sciences, 2011-11, Vol.100 (11), p.4974-4985

2011

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Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion

Drug metabolism and disposition, 2012-08, Vol.40 (8), p.1527-1537

2012

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In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

Drug metabolism and disposition, 2012-06, Vol.40 (6), p.1085-1092

2012

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Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin

Drug metabolism and disposition, 2013-05, Vol.41 (5), p.966-974

2013

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Strategies for skeletal muscle targeting in drug discovery

Current pharmaceutical design, 2015-01, Vol.21 (10), p.1327-1336

2015

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Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

Emerging microbes & infections, 2019-01, Vol.8 (1), p.624-636

2019

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Molecular properties associated with transporter-mediated drug disposition

Advanced drug delivery reviews, 2017-07, Vol.116, p.92-99

2017

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Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes

Drug metabolism and disposition, 2012-02, Vol.40 (2), p.407-411

2012

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pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

Molecular pharmaceutics, 2012-05, Vol.9 (5), p.1199-1212

2012

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A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

Drug metabolism and disposition, 2018-04, Vol.46 (4), p.346-356

2018

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pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1

Molecular pharmaceutics, 2011-08, Vol.8 (4), p.1303-1313

2011

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Renal Transporters in Drug Disposition, Drug‐Drug Interactions, and Nephrotoxicity

Current Protocols in Toxicology, 2012-08, Vol.53 (1), p.23.3.1-23.3.15

2012

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2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

Journal of medicinal chemistry, 2018-04, Vol.61 (7), p.3114-3125

2018

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Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

Expert opinion on drug metabolism & toxicology, 2013-04, Vol.9 (4), p.459-472

2013

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Diethylation Labeling Combined with UPLC/MS/MS for Simultaneous Determination of a Panel of Monoamine Neurotransmitters in Rat Prefrontal Cortex Microdialysates

Analytical chemistry (Washington), 2008-12, Vol.80 (23), p.9195-9203

2008

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The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems

International journal of pharmaceutics, 2000-04, Vol.198 (2), p.179-189

2000

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The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities

International journal of pharmaceutics, 2001-03, Vol.215 (1), p.229-240

2001

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Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models

Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)

In situ evaluation of the impact of metformin or verapamil coadministration with vildagliptin on its regional absorption from the rabbit’s intestine

Targeting intestinal transporters for optimizing oral drug absorption

Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development

Navigating Transporter Sciences in Pharmacokinetics Characterization Using Extended Clearance Classification System (ECCS)

Mechanistic Modeling to Predict the Transporter- and Enzyme-Mediated Drug-Drug Interactions of Repaglinide

Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System

Development of a new permeability assay using low‐efflux MDCKII cells

Physicochemical property space of hepatobiliary transport and computational models for predicting rat biliary excretion

In vitro evaluation of hepatic transporter-mediated clinical drug-drug interactions: hepatocyte model optimization and retrospective investigation

Quantitative prediction of repaglinide-rifampicin complex drug interactions using dynamic and static mechanistic models: delineating differential CYP3A4 induction and OATP1B1 inhibition potential of rifampicin

Strategies for skeletal muscle targeting in drug discovery

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

Molecular properties associated with transporter-mediated drug disposition

Differential modulation of cytochrome P450 activity and the effect of 1-aminobenzotriazole on hepatic transport in sandwich-cultured human hepatocytes

pH-Dependent Solubility and Permeability Criteria for Provisional Biopharmaceutics Classification (BCS and BDDCS) in Early Drug Discovery

A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 1: Translating Systemic Plasma Concentration to Liver Exposure in Healthy Subjects

pH-Sensitive Interaction of HMG-CoA Reductase Inhibitors (Statins) with Organic Anion Transporting Polypeptide 2B1

Renal Transporters in Drug Disposition, Drug‐Drug Interactions, and Nephrotoxicity

2‑Aminopyridine-Based Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Inhibitors: Assessment of Mechanism-Based Safety

Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond

Diethylation Labeling Combined with UPLC/MS/MS for Simultaneous Determination of a Panel of Monoamine Neurotransmitters in Rat Prefrontal Cortex Microdialysates

The effect of terpene enhancer lipophilicity on the percutaneous permeation of hydrocortisone formulated in HPMC gel systems

The effects of terpene enhancers on the percutaneous permeation of drugs with different lipophilicities

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