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Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

Nature reviews. Endocrinology, 2020-07, Vol.16 (7), p.349-362

2020

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The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

Endocrine reviews, 2008-02, Vol.29 (1), p.42-61

2008

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The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

PLoS genetics, 2012-03, Vol.8 (3), p.e1002552-e1002552

2012

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Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

Diabetologia, 2020-10, Vol.63 (10), p.1999-2006

2020

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The role of inflammation in insulitis and β-cell loss in type 1 diabetes

Nature reviews. Endocrinology, 2009-04, Vol.5 (4), p.219-226

2009

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Viral infections in type 1 diabetes mellitus--why the β cells?

Nature reviews. Endocrinology, 2016-05, Vol.12 (5), p.263-273

2016

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Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Nature reviews. Endocrinology, 2023-07, Vol.19 (7), p.425-434

2023

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Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Journal of cell science, 2008-07, Vol.121 (14), p.2308-2318

2008

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Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

Cell reports (Cambridge), 2015-02, Vol.10 (5), p.711-725

2015

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CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

Cell metabolism, 2018-11, Vol.28 (5), p.750-763.e6

2018

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The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Nature communications, 2016-11, Vol.7 (1), p.13479-13479, Article 13479

2016

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Resistance to type 2 diabetes mellitus: a matter of hormesis?

Nature reviews. Endocrinology, 2012-03, Vol.8 (3), p.183-192

2012

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From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

Diabetes (New York, N.Y.), 2021-09, Vol.70 (9), p.1915-1925

2021

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SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β -Cells and in the Human Pancreas Microvasculature

Frontiers in endocrinology (Lausanne), 2020-11, Vol.11, p.596898-596898

2020

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Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

Trends in cell biology, 2011-07, Vol.21 (7), p.424-431

2011

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RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Diabetes (New York, N.Y.), 2014-06, Vol.63 (6), p.1978-1993

2014

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Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Nucleic acids research, 2018-11, Vol.46 (19), p.10302-10318

2018

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Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway

Cell death and differentiation, 2016-12, Vol.23 (12), p.1995-2006

2016

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MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Diabetes (New York, N.Y.), 2017-01, Vol.66 (1), p.100-112

2017

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Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice

Diabetes (New York, N.Y.), 2020-12, Vol.69 (12), p.2678-2690

2020

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GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

PLoS genetics, 2013-05, Vol.9 (5), p.e1003532-e1003532

2013

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ER stress in pancreatic beta cells: the thin red line between adaptation and failure

Science signaling, 2010-02, Vol.3 (110), p.pe7

2010

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Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress―Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Diabetes (New York, N.Y.), 2012-11, Vol.61 (11), p.2763-2775

2012

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Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes

Diabetes (New York, N.Y.), 2015-02, Vol.64 (2), p.573-586

2015

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Pancreatic β-cells in type 1 and type 2 diabetes mellitus: different pathways to failure

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines

Presumption of innocence for beta cells: why are they vulnerable autoimmune targets in type 1 diabetes?

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

Viral infections in type 1 diabetes mellitus--why the β cells?

Why does the immune system destroy pancreatic β-cells but not α-cells in type 1 diabetes?

Initiation and execution of lipotoxic ER stress in pancreatic β-cells

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors

CXCL14, a Brown Adipokine that Mediates Brown-Fat-to-Macrophage Communication in Thermogenic Adaptation

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

Resistance to type 2 diabetes mellitus: a matter of hormesis?

From Pancreatic β-Cell Gene Networks to Novel Therapies for Type 1 Diabetes

SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β -Cells and in the Human Pancreas Microvasculature

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

RNA Sequencing Identifies Dysregulation of the Human Pancreatic Islet Transcriptome by the Saturated Fatty Acid Palmitate

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes

Thrombospondin 1 protects pancreatic β-cells from lipotoxicity via the PERK-NRF2 pathway

MicroRNAs miR-23a-3p, miR-23b-3p, and miR-149-5p Regulate the Expression of Proapoptotic BH3-Only Proteins DP5 and PUMA in Human Pancreatic β-Cells

Peptides Derived From Insulin Granule Proteins Are Targeted by CD8 + T Cells Across MHC Class I Restrictions in Humans and NOD Mice

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim

ER stress in pancreatic beta cells: the thin red line between adaptation and failure

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress―Mitochondrial Dialog Triggering Lipotoxic Rodent and Human β-Cell Apoptosis

Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes

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