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Three-Dimensional Cell Cultures in Drug Discovery and Development

SLAS Discovery, 2017-06, Vol.22 (5), p.456-472

2017

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

Nature reviews. Drug discovery, 2007-09, Vol.6 (9), p.721-733

2007

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Overview of muscarinic receptor subtypes

Handbook of experimental pharmacology, 2012 (208), p.3

Eglen, Richard M

2012

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Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

Assay and drug development technologies, 2015-06, Vol.13 (5), p.262

2015

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Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids, and Disease Modeling

SLAS TECHNOLOGY: Translating Life Sciences Innovation, 2019-02, Vol.24 (1), p.18-27

2019

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Convergence of Three-Dimensional Cell Culture and Human iPS Cells: Improving Clinical Relevance in Drug Discovery

SLAS technology, 2019-02, Vol.24 (1), p.1-2

Eglen, Richard M.

2019

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Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 1: Target Identification and Lead Optimization

SLAS TECHNOLOGY: Translating Life Sciences Innovation, 2019-02, Vol.24 (1), p.3-17

2019

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The current status of drug discovery against the human kinome

Assay and drug development technologies, 2009-02, Vol.7 (1), p.22-43

2009

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Muscarinic Receptor Subtype Pharmacology and Physiology

Progress in Medicinal Chemistry, 2005, Vol.43, p.105-136

Eglen, Richard M.

2005

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Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

Assay and drug development technologies, 2015-06, Vol.13 (5), p.262-265

2015

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Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview

Journal of biomolecular screening, 2011-12, Vol.16 (10), p.1137-1152

2011

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Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening

Assay and drug development technologies, 2007-06, Vol.5 (3), p.425-452

2007

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The use of immortalized cell lines in GPCR screening: the good, bad and ugly

Combinatorial chemistry & high throughput screening, 2008-08, Vol.11 (7), p.560-565

2008

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Functional G protein-coupled receptor assays for primary and secondary screening

Combinatorial chemistry & high throughput screening, 2005-06, Vol.8 (4), p.311-318

Eglen, Richard M

2005

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New insights into GPCR function: implications for HTS

Methods in molecular biology (Clifton, N.J.), 2009-01, Vol.552, p.1

2009

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Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions

The Journal of neuroscience, 1998-03, Vol.18 (6), p.2174-2187

1998

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An overview of drug screening using primary and embryonic stem cells

Combinatorial chemistry & high throughput screening, 2008-08, Vol.11 (7), p.566-572

2008

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Three-Dimensional Cell Culture: A Rapidly Emerging Approach to Cellular Science and Drug Discovery

SLAS discovery, 2017-06, Vol.22 (5), p.453-455

2017

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Drug discovery and the human kinome: recent trends

Pharmacology & therapeutics (Oxford), 2011-05, Vol.130 (2), p.144-156

2011

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GPCRs Revisited: New Insights Lead to Novel Drugs

Pharmaceuticals, 2011-02, Vol.4 (2), p.244-272

2011

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Beta galactosidase complementation: a cell-based luminescent assay platform for drug discovery

Assay and drug development technologies, 2007-02, Vol.5 (1), p.137-144

2007

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Human kinome drug discovery and the emerging importance of atypical allosteric inhibitors

Expert opinion on drug discovery, 2010-03, Vol.5 (3), p.277-290

2010

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A generic, homogenous method for measuring kinase and inhibitor activity via adenosine 5'-diphosphate accumulation

Journal of biomolecular screening, 2006-06, Vol.11 (4), p.390-399

2006

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Therapeutic opportunities from muscarinic receptor research

Trends in Pharmacological Sciences, 2001-08, Vol.22 (8), p.409-414

2001

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Photoproteins: important new tools in drug discovery

Assay and drug development technologies, 2008-10, Vol.6 (5), p.659-672

2008

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Three-Dimensional Cell Cultures in Drug Discovery and Development

Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

Overview of muscarinic receptor subtypes

Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 2: Spheroids, Organoids, and Disease Modeling

Convergence of Three-Dimensional Cell Culture and Human iPS Cells: Improving Clinical Relevance in Drug Discovery

Human iPS Cell-Derived Patient Tissues and 3D Cell Culture Part 1: Target Identification and Lead Optimization

The current status of drug discovery against the human kinome

Muscarinic Receptor Subtype Pharmacology and Physiology

Drug Discovery Goes Three-Dimensional: Goodbye to Flat High-Throughput Screening?

Screening for compounds that modulate epigenetic regulation of the transcriptome: an overview

Emerging concepts of guanine nucleotide-binding protein-coupled receptor (GPCR) function and implications for high throughput screening

The use of immortalized cell lines in GPCR screening: the good, bad and ugly

Functional G protein-coupled receptor assays for primary and secondary screening

New insights into GPCR function: implications for HTS

Distribution of the Tetrodotoxin-Resistant Sodium Channel PN3 in Rat Sensory Neurons in Normal and Neuropathic Conditions

An overview of drug screening using primary and embryonic stem cells

Three-Dimensional Cell Culture: A Rapidly Emerging Approach to Cellular Science and Drug Discovery

Drug discovery and the human kinome: recent trends

GPCRs Revisited: New Insights Lead to Novel Drugs

Beta galactosidase complementation: a cell-based luminescent assay platform for drug discovery

Human kinome drug discovery and the emerging importance of atypical allosteric inhibitors

A generic, homogenous method for measuring kinase and inhibitor activity via adenosine 5'-diphosphate accumulation

Therapeutic opportunities from muscarinic receptor research

Photoproteins: important new tools in drug discovery

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