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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Nature (London), 2010-08, Vol.466 (7309), p.935-940

2010

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Crystal Structure of Human Cytochrome P450 2D6

The Journal of biological chemistry, 2006-03, Vol.281 (11), p.7614-7622

2006

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Synthesis and Recognition Properties of Aromatic Amide Oligomers: Molecular Zippers

Journal of the American Chemical Society, 2000-09, Vol.122 (37), p.8856-8868

2000

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The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn

Journal of medicinal chemistry, 1993-12, Vol.36 (26), p.4131-4138

1993

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The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA

Journal of molecular biology, 2000-01, Vol.295 (1), p.105-115

2000

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1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Journal of medicinal chemistry, 1998-03, Vol.41 (6), p.821-835

1998

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Structure determination of racemic trichogin A IV using centrosymmetric crystals

Nature structural & molecular biology, 1994-12, Vol.1 (12), p.908-914

1994

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Substituent effects on aromatic interactions in the solid state

Chemical communications (Cambridge, England), 2001 (16), p.1500-1501

2001

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Structure and redox properties of the water-oxidation catalyst [(bpy)2(OH2)RuORu(OH2)(bpy)2]4

Journal of the American Chemical Society, 1985-06, Vol.107 (13), p.3855-3864

1985

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Defining and maintaining a high quality screening collection: the GSK experience

Drug discovery today, 2006-03, Vol.11 (5-6), p.267-272

2006

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Non-thiazolidinedione antihyperglycaemic agents. Part 5: Asymmetric aldol synthesis of ( S)-(−)-2-oxy-3-arylpropanoic acids

Tetrahedron: asymmetry, 1999-04, Vol.10 (7), p.1353-1367

1999

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The Many Faces of RNA

1, 1997

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Design and synthesis of a C7 mimetic for the predicted .gamma.-turn conformation found in several constrained RGD antagonists

Journal of medicinal chemistry, 1992-10, Vol.35 (21), p.3970-3972

1992

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Structure–activity analysis of truncated orexin-A analogues at the orexin-1 receptor

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (5), p.737-740

2001

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Metal-assisted aldol condensation of chiral .alpha.-halogenated imide enolates: a stereocontrolled chiral epoxide synthesis

Journal of the American Chemical Society, 1986-07, Vol.108 (15), p.4595-4602

1986

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Synthesis of imidazoles via hetero-Cope rearrangements

Journal of organic chemistry, 1993-12, Vol.58 (25), p.7092-7095

1993

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Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain

The European journal of neuroscience, 2000-08, Vol.12 (8), p.2847-2855

2000

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Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Journal of medicinal chemistry, 1999-02, Vol.42 (4), p.545-559

1999

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Discovery of a Novel Class of Substituted Pyrrolooctahydroisoquinolines as Potent and Selective δ Opioid Agonists, Based on an Extension of the Message−Address Concept

Journal of medicinal chemistry, 1997-09, Vol.40 (20), p.3192-3198

1997

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(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists

Journal of medicinal chemistry, 1994-09, Vol.37 (20), p.3327-3336

1994

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Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383

Bioorganic & medicinal chemistry letters, 2000-08, Vol.10 (16), p.1811-1814

2000

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Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase

Bioorganic & medicinal chemistry letters, 2001-03, Vol.11 (5), p.711-714

2001

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Chelation control in metal-assisted aldol addition reactions of .alpha.-N-halogenated imide enolates leading to predominantly anti stereoselectivity. An example of a stereocontrolled Darzens reaction

Journal of organic chemistry, 1993-09, Vol.58 (19), p.5107-5117

1993

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Design and synthesis of conformationally restricted eight-Membered ring diketones as potential serine protease inhibitors

Bioorganic & medicinal chemistry letters, 2002-09, Vol.12 (17), p.2359-2362

2002

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A Screen for Inhibitors of DNA Recombination: Identification of Two New Spirostanol Glycosides from Chamaedorea linearis

Journal of natural products (Washington, D.C.), 1993-09, Vol.56 (9), p.1451-1458

1993

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Type IIA topoisomerase inhibition by a new class of antibacterial agents

Crystal Structure of Human Cytochrome P450 2D6

Synthesis and Recognition Properties of Aromatic Amide Oligomers: Molecular Zippers

The inophyllums, novel inhibitors of HIV-1 reverse transcriptase isolated from the Malaysian tree, Calophyllum inophyllum Linn

The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA

1,4-Cyclohexanecarboxylates: Potent and Selective Inhibitors of Phosophodiesterase 4 for the Treatment of Asthma

Structure determination of racemic trichogin A IV using centrosymmetric crystals

Substituent effects on aromatic interactions in the solid state

Structure and redox properties of the water-oxidation catalyst [(bpy)2(OH2)RuORu(OH2)(bpy)2]4

Defining and maintaining a high quality screening collection: the GSK experience

Non-thiazolidinedione antihyperglycaemic agents. Part 5: Asymmetric aldol synthesis of ( S)-(−)-2-oxy-3-arylpropanoic acids

The Many Faces of RNA

Design and synthesis of a C7 mimetic for the predicted .gamma.-turn conformation found in several constrained RGD antagonists

Structure–activity analysis of truncated orexin-A analogues at the orexin-1 receptor

Metal-assisted aldol condensation of chiral .alpha.-halogenated imide enolates: a stereocontrolled chiral epoxide synthesis

Synthesis of imidazoles via hetero-Cope rearrangements

Cellular uptake and spread of the cell-permeable peptide penetratin in adult rat brain

Conformational Preferences in a Benzodiazepine Series of Potent Nonpeptide Fibrinogen Receptor Antagonists

Discovery of a Novel Class of Substituted Pyrrolooctahydroisoquinolines as Potent and Selective δ Opioid Agonists, Based on an Extension of the Message−Address Concept

(E)-3-[[[[6-(2-Carboxyethenyl)-5-[[8-(4-methoxyphenyl)octyl]oxy]-2-pyridinyl]methyl]thio]methyl]benzoic Acid and Related Compounds: High Affinity Leukotriene B4 Receptor Antagonists

Inhibitors of bacterial tyrosyl tRNA synthetase: synthesis of four stereoisomeric analogues of the natural product SB-219383

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase

Chelation control in metal-assisted aldol addition reactions of .alpha.-N-halogenated imide enolates leading to predominantly anti stereoselectivity. An example of a stereocontrolled Darzens reaction

Design and synthesis of conformationally restricted eight-Membered ring diketones as potential serine protease inhibitors

A Screen for Inhibitors of DNA Recombination: Identification of Two New Spirostanol Glycosides from Chamaedorea linearis

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