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Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia

The Journal of pharmacology and experimental therapeutics, 2009-11, Vol.331 (2), p.574-590

2009

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Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test

Psychopharmacologia, 2012-05, Vol.221 (2), p.249-259

2012

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Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Journal of medicinal chemistry, 2011-11, Vol.54 (21), p.7621-7638

2011

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Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3), p.556

2018

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Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A

Journal of labelled compounds & radiopharmaceuticals, 2017-01, Vol.60 (1), p.36-48

2017

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Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase 10 A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism

ChemMedChem, 2014-07, Vol.9 (7), p.1476-1487

2014

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Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations

The Journal of pharmacology and experimental therapeutics, 2004-02, Vol.308 (2), p.555-563

2004

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Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography

Molecules (Basel, Switzerland), 2015-05, Vol.20 (6), p.9591-9615

2015

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Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.717

2005

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Discovery of triazines as potent, selective and orally active PDE4 inhibitors

Bioorganic & medicinal chemistry letters, 2013-08, Vol.23 (15), p.4308-4314

2013

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Large-Scale Mining for Similar Protein Binding Pockets: With RAPMAD Retrieval on the Fly Becomes Real

Journal of chemical information and modeling, 2015-01, Vol.55 (1), p.165-179

2015

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Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines

European journal of medicinal chemistry, 2016-01, Vol.107, p.97-108

2016

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Synthesis and structure–activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors

Bioorganic & medicinal chemistry letters, 2011-11, Vol.21 (22), p.6652-6656

2011

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Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

Journal of medicinal chemistry, 2010-06, Vol.53 (11), p.4399-4411

2010

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New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity

European journal of medicinal chemistry, 2007-06, Vol.42 (6), p.873-879

2007

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Novel triazines as potent and selective phosphodiesterase 10A inhibitors

Bioorganic & medicinal chemistry letters, 2012-09, Vol.22 (18), p.5876-5884

2012

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Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase10A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism

ChemMedChem, 2014-07, Vol.9 (7), p.1476-1487

2014

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Investigation of an 18 F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Molecules (Basel, Switzerland), 2018-03, Vol.23 (3)

2018

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Synthesis, Pharmacology, and Structure−Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABAA Receptors

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.1855-1866

2006

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Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABA A Receptor

The Journal of pharmacology and experimental therapeutics, 2005-08, Vol.314 (2), p.717-724

2005

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Synthesis, Pharmacology, and Structure−Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABA A Receptors

Journal of medicinal chemistry, 2006-03, Vol.49 (6), p.1855-1866

2006

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Inhibitors of the phosphodiesterase 2 increased axonal fibre growth in a dopaminergic organotypic ex vivo slice co-culture model

BMC pharmacology, 2011-08, Vol.11 (S1), p.P34-P34, Article P34

2011

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New GABAmodulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity

European journal of medicinal chemistry, 2007, Vol.42 (6), p.873-879

2007

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ChemInform Abstract: Discovery of Triazines as Potent, Selective and Orally Active PDE4 Inhibitors

ChemInform, 2013-11, Vol.44 (47), p.no-no

2013

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RNA-based drug screening using automated RNA purification and real-time RT-PCR1

Journal of biomolecular screening, 2004-03, Vol.9 (2), p.95-102

2004

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Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia

Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Radiosynthesis and biological evaluation of the new PDE10A radioligand [18F]AQ28A

Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase 10 A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism

Anti-inflammatory potential of the selective phosphodiesterase 4 inhibitor N-(3,5-dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12-281), in human cell preparations

Synthesis, 18F-Radiolabelling and Biological Characterization of Novel Fluoroalkylated Triazine Derivatives for in Vivo Imaging of Phosphodiesterase 2A in Brain via Positron Emission Tomography

Characterization in rats of the anxiolytic potential of ELB139 [1-(4-chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a new agonist at the benzodiazepine binding site of the GABAA receptor

Discovery of triazines as potent, selective and orally active PDE4 inhibitors

Large-Scale Mining for Similar Protein Binding Pockets: With RAPMAD Retrieval on the Fly Becomes Real

Development of highly potent phosphodiesterase 10A (PDE10A) inhibitors: Synthesis and in vitro evaluation of 1,8-dipyridinyl- and 1-pyridinyl-substituted imidazo[1,5-a]quinoxalines

Synthesis and structure–activity relationship studies of dihydronaphthyridinediones as a novel structural class of potent and selective PDE7 inhibitors

Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity

Novel triazines as potent and selective phosphodiesterase 10A inhibitors

Fluorine-Containing 6,7-Dialkoxybiaryl-Based Inhibitors for Phosphodiesterase10A: Synthesis and in vitro Evaluation of Inhibitory Potency, Selectivity, and Metabolism

Investigation of an 18 F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A

Synthesis, Pharmacology, and Structure−Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABAA Receptors

Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABA A Receptor

Synthesis, Pharmacology, and Structure−Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABA A Receptors

Inhibitors of the phosphodiesterase 2 increased axonal fibre growth in a dopaminergic organotypic ex vivo slice co-culture model

New GABAmodulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity

ChemInform Abstract: Discovery of Triazines as Potent, Selective and Orally Active PDE4 Inhibitors

RNA-based drug screening using automated RNA purification and real-time RT-PCR1

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