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Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

Journal of medicinal chemistry, 2014-07, Vol.57 (13), p.5800-5816

2014

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HIV integrase inhibitors: from diketoacids to heterocyclic templates: a history of HIV integrase medicinal chemistry at Merck West Point and Merck Rome (IRBM)

Current topics in medicinal chemistry, 2007-07, Vol.7 (13), p.1251-1272

Egbertson, Melissa S

2007

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The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys

Neuropharmacology, 2013-01, Vol.64, p.191-196

2013

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Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species

Bioorganic & medicinal chemistry letters, 2018-04, Vol.28 (6), p.1122-1126

2018

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Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

Journal of medicinal chemistry, 2003-02, Vol.46 (4), p.453-456

2003

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4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

Journal of medicinal chemistry, 2000-12, Vol.43 (26), p.4923-4926

2000

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Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase

Bioorganic & medicinal chemistry, 2008-10, Vol.18 (19), p.5307-5310

2008

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A potent and orally active HIV-1 integrase inhibitor

Bioorganic & medicinal chemistry letters, 2007-03, Vol.17 (5), p.1392-1398

2007

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Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp

Journal of medicinal chemistry, 1994-08, Vol.37 (16), p.2537-2551

1994

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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Journal of medicinal chemistry, 1999-07, Vol.42 (13), p.2409-2421

1999

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Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets

The Journal of pharmacology and experimental therapeutics, 1998-06, Vol.285 (3), p.1317

1998

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Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species

Bioorganic & medicinal chemistry letters, 2018-04, Vol.28 (6)

2018

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A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase

Proceedings of the National Academy of Sciences - PNAS, 2004-08, Vol.101 (31), p.11233-11238

2004

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Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Bioorganic & medicinal chemistry letters, 2000-09, Vol.10 (17), p.1943-1948

2000

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Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Journal of medicinal chemistry, 1999-09, Vol.42 (19), p.4014-4014

1999

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HIV Integrase Inhibitors: From Diketo Acids to Heterocyclic Templates: History of HIV Integrase Medicinal Chemistry at Merck West Point and Merck Rome (IRBM) Leading to Discovery of Raltegravir

HIV-1 Integrase, 2011, Vol.9, p.197-229

2011

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Discovery of MK‐0536: A Potential Second‐Generation HIV‐1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation

Antiviral Drugs, 2011, p.163-180

2011

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Practical Synthesis of 4-Fluoro-2-(methylthio)benzylamine and the Corresponding Sulfone and Sulfonamide

Synthetic communications, 2007-06, Vol.37 (11), p.1887-1897

2007

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Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

Journal of medicinal chemistry, 1992-11, Vol.35 (24), p.4640-4642

1992

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A Simple Method of Protecting a Secondary Amine with Tert Butyloxycarbonyl (Boc) in the Presence of a Primary Amine

Synthetic communications, 1992-08, Vol.22 (16), p.2357-2360

1992

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Practical Synthesis of 4-Fluoro-2-(methylthio)benzylamine (V) and the Corresponding Sulfone (X) and Sulfonamide (XVI)

ChemInform, 2007-11, Vol.38 (45), p.no-no

2007

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Tirofiban (Aggrastat®)

Cardiovascular drug reviews, 1999-09, Vol.17 (3), p.199-224

1999

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Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine‐glycine‐aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets

Cytometry (New York, N.Y.), 1997-05, Vol.28 (1), p.58-65

1997

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Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes

Proceedings of the National Academy of Sciences - PNAS, 2002-05, Vol.99 (10), p.6661-6666

2002

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HIV-1 Integrase Inhibitors That Compete with the Target DNA Substrate Define a Unique Strand Transfer Conformation for Integrase

Proceedings of the National Academy of Sciences - PNAS, 2000-10, Vol.97 (21), p.11244-11249

2000

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Maximizing Diversity from a Kinase Screen: Identification of Novel and Selective pan-Trk Inhibitors for Chronic Pain

HIV integrase inhibitors: from diketoacids to heterocyclic templates: a history of HIV integrase medicinal chemistry at Merck West Point and Merck Rome (IRBM)

The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys

Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species

Design and Synthesis of 8-Hydroxy-[1,6]Naphthyridines as Novel Inhibitors of HIV-1 Integrase in Vitro and in Infected Cells

4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase

A potent and orally active HIV-1 integrase inhibitor

Non-Peptide Fibrinogen Receptor Antagonists. 2. Optimization of a Tyrosine Template as a Mimic for Arg-Gly-Asp

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

Identification of low molecular weight GP IIb/IIIa antagonists that bind preferentially to activated platelets

Indole acids as a novel PDE2 inhibitor chemotype that demonstrate pro-cognitive activity in multiple species

A Naphthyridine Carboxamide Provides Evidence for Discordant Resistance between Mechanistically Identical Inhibitors of HIV-1 Integrase

Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene α-Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation

HIV Integrase Inhibitors: From Diketo Acids to Heterocyclic Templates: History of HIV Integrase Medicinal Chemistry at Merck West Point and Merck Rome (IRBM) Leading to Discovery of Raltegravir

Discovery of MK‐0536: A Potential Second‐Generation HIV‐1 Integrase Strand Transfer Inhibitor with a High Genetic Barrier to Mutation

Practical Synthesis of 4-Fluoro-2-(methylthio)benzylamine and the Corresponding Sulfone and Sulfonamide

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors

A Simple Method of Protecting a Secondary Amine with Tert Butyloxycarbonyl (Boc) in the Presence of a Primary Amine

Practical Synthesis of 4-Fluoro-2-(methylthio)benzylamine (V) and the Corresponding Sulfone (X) and Sulfonamide (XVI)

Tirofiban (Aggrastat®)

Flow cytometric measurement of kinetic and equilibrium binding parameters of arginine‐glycine‐aspartic acid ligands in binding to glycoprotein IIb/IIIa on platelets

Diketo Acid Inhibitor Mechanism and HIV-1 Integrase: Implications for Metal Binding in the Active Site of Phosphotransferase Enzymes

HIV-1 Integrase Inhibitors That Compete with the Target DNA Substrate Define a Unique Strand Transfer Conformation for Integrase

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