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Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

Journal of inorganic biochemistry, 2008-05, Vol.102 (5-6), p.1288-1299

Egan, Timothy J.

2008

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Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application

Current topics in medicinal chemistry, 2020-01, Vol.20 (8), p.617

2020

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Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Scientific reports, 2023-02, Vol.13 (1), p.2648-2648, Article 2648

2023

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Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites

Scientific reports, 2020-02, Vol.10 (1), p.3374-3374, Article 3374

2020

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Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites

Molecules (Basel, Switzerland), 2020-03, Vol.25 (7), p.1571

2020

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4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

Journal of medicinal chemistry, 2017-12, Vol.60 (24), p.10245-10256

2017

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The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

ACS chemical biology, 2011-03, Vol.6 (3), p.275-287

2011

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Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development

Accounts of chemical research, 2021-06, Vol.54 (11), p.2649-2659

2021

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Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-Resistant Plasmodium falciparum and Inhibit Chloroquine Transport via the P. falciparum Chloroquine-Resistance Transporter (PfCRT)

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6956-6968

2011

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Speciation of Ferriprotoporphyrin IX in Aqueous and Mixed Aqueous Solution Is Controlled by Solvent Identity, pH, and Salt Concentration

Inorganic chemistry, 2009-08, Vol.48 (16), p.7994-8003

2009

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Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides

International journal for parasitology -- drugs and drug resistance, 2024-08, Vol.25, p.100536-100536, Article 100536

2024

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Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition

Malaria journal, 2012-10, Vol.11 (1), p.337-337, Article 337

2012

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Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties

Antimicrobial agents and chemotherapy, 2018-05, Vol.62 (5)

2018

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Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator

The Lancet infectious diseases, 2007-10, Vol.7 (10), p.675-685

2007

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Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

PLoS pathogens, 2016-11, Vol.12 (11), p.e1005976-e1005976

2016

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Interplay between Plasmodium falciparum haemozoin and L-arginine: implication for nitric oxide production

Malaria journal, 2018-12, Vol.17 (1), p.456-456, Article 456

2018

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Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

International journal for parasitology -- drugs and drug resistance, 2020-08, Vol.13, p.51-58

2020

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Heterogeneous catalysis with encapsulated haem and other synthetic porphyrins: Harnessing the power of porphyrins for oxidation reactions

Open Chemistry, 2018-01, Vol.16 (1), p.763-789

2018

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Haemozoin formation

Molecular and biochemical parasitology, 2008-02, Vol.157 (2), p.127-136

Egan, Timothy J.

2008

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The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

Journal of inorganic biochemistry, 2008-08, Vol.102 (8), p.1660-1667

2008

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Fate of haem iron in the malaria parasite Plasmodium falciparum

Biochemical journal, 2002-07, Vol.365 (Pt 2), p.343-347

2002

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Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface

FEBS letters, 2006-09, Vol.580 (21), p.5105-5110

2006

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Structure−Activity Relationships in 4-Aminoquinoline Antiplasmodials. The Role of the Group at the 7-Position

Journal of medicinal chemistry, 2002-08, Vol.45 (16), p.3531-3539

2002

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Recent advances in the discovery of haem-targeting drugs for malaria and schistosomiasis

Molecules, 2009-08, Vol.14 (8), p.2868-2887

2009

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Effects of N-Glycosylation of the human cation channel TRPA1 on agonist-sensitivity

Bioscience reports, 2016-10, Vol.36 (5)

2016

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Recent advances in understanding the mechanism of hemozoin (malaria pigment) formation

Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application

Identifying inhibitors of β-haematin formation with activity against chloroquine-resistant Plasmodium falciparum malaria parasites via virtual screening approaches

Virtual screening as a tool to discover new β-haematin inhibitors with activity against malaria parasites

Lapatinib, Nilotinib and Lomitapide Inhibit Haemozoin Formation in Malaria Parasites

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance

Heme Detoxification in the Malaria Parasite: A Target for Antimalarial Drug Development

Quinoline Antimalarials Containing a Dibemethin Group Are Active against Chloroquinone-Resistant Plasmodium falciparum and Inhibit Chloroquine Transport via the P. falciparum Chloroquine-Resistance Transporter (PfCRT)

Speciation of Ferriprotoporphyrin IX in Aqueous and Mixed Aqueous Solution Is Controlled by Solvent Identity, pH, and Salt Concentration

Discovery of antiplasmodial pyridine carboxamides and thiocarboxamides

Neutral lipids associated with haemozoin mediate efficient and rapid β-haematin formation at physiological pH, temperature and ionic composition

Prediction Model for Antimalarial Activities of Hemozoin Inhibitors by Using Physicochemical Properties

Haemozoin: from melatonin pigment to drug target, diagnostic tool, and immune modulator

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

Interplay between Plasmodium falciparum haemozoin and L-arginine: implication for nitric oxide production

Naphthylisoquinoline alkaloids, validated as hit multistage antiplasmodial natural products

Heterogeneous catalysis with encapsulated haem and other synthetic porphyrins: Harnessing the power of porphyrins for oxidation reactions

Haemozoin formation

The crystal structure of halofantrine–ferriprotoporphyrin IX and the mechanism of action of arylmethanol antimalarials

Fate of haem iron in the malaria parasite Plasmodium falciparum

Haemozoin (β-haematin) biomineralization occurs by self-assembly near the lipid/water interface

Structure−Activity Relationships in 4-Aminoquinoline Antiplasmodials. The Role of the Group at the 7-Position

Recent advances in the discovery of haem-targeting drugs for malaria and schistosomiasis

Effects of N-Glycosylation of the human cation channel TRPA1 on agonist-sensitivity

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