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Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines

British journal of pharmacology, 2022-07, Vol.179 (14), p.3496-3511

2022

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Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

Structure (London), 2018-02, Vol.26 (2), p.259-269.e5

2018

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Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor

Cell, 2018-01, Vol.172 (1-2), p.68-80.e12

2018

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Anionic phospholipids control mechanisms of GPCR-G protein recognition

Nature communications, 2023-02, Vol.14 (1), p.794-794, Article 794

2023

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Structural biology of human GPCR drugs and endogenous ligands - insights from NMR spectroscopy

Methods (San Diego, Calif.), 2020-08, Vol.180, p.79-88

2020

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β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

Structure (London), 2016-12, Vol.24 (12), p.2190-2197

2016

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Spectroscopy by Integration of Frequency and Time Domain Information for Fast Acquisition of High-Resolution Dark Spectra

Journal of the American Chemical Society, 2009-04, Vol.131 (13), p.4648-4656

2009

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GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

Nature reviews. Drug discovery, 2019-01, Vol.18 (1), p.59-82

2019

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Production of a Human Histamine Receptor for NMR Spectroscopy in Aqueous Solutions

Biomolecules (Basel, Switzerland), 2021-04, Vol.11 (5), p.632

2021

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Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence spectroscopy

STAR protocols, 2022-09, Vol.3 (3), p.101535-101535, Article 101535

2022

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Magic Angle Spinning Nuclear Magnetic Resonance Characterization of Voltage-Dependent Anion Channel Gating in Two-Dimensional Lipid Crystalline Bilayers

Biochemistry (Easton), 2015-02, Vol.54 (4), p.994-1005

2015

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Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations

Communications biology, 2023-11, Vol.6 (1), p.1218-1218, Article 1218

2023

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Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR

Journal of biomolecular NMR, 2015-04, Vol.61 (3-4), p.299-310

2015

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Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor

Journal of the American Chemical Society, 2018-07, Vol.140 (26), p.8228-8235

2018

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A comparative study of interfacial environments in lipid nanodiscs and vesicles

Biophysical reports, 2022-09, Vol.2 (3), p.100066, Article 100066

2022

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A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch

Structure (London), 2021-02, Vol.29 (2), p.170-176.e3

2021

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Selectively dispersed isotope labeling for protein structure determination by magic angle spinning NMR

Journal of biomolecular NMR, 2013-10, Vol.57 (2), p.129-139

2013

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Proton Assisted Recoupling at High Spinning Frequencies

The journal of physical chemistry. B, 2009-07, Vol.113 (27), p.9062-9069

2009

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Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition

Structure (London), 2023-07, Vol.31 (7), p.836-847.e6

2023

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NMR Spectroscopic Studies of Ion Channels in Lipid Bilayers: Sample Preparation Strategies Exemplified by the Voltage Dependent Anion Channel

Methods in molecular biology (Clifton, N.J.), 2021-01, Vol.2302, p.201

2021

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Radio frequency-driven recoupling at high magic-angle spinning frequencies: Homonuclear recoupling sans heteronuclear decoupling

The Journal of chemical physics, 2008-02, Vol.128 (5), p.052321-052321-11

2008

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Interaction networks within disease-associated GαS variants characterized by an integrative biophysical approach

The Journal of biological chemistry, 2024-08, Vol.300 (8), p.107497, Article 107497

2024

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New Insights into the Structure‐Function Relationships of G Proteins Containing Disease‐Associated Mutations

The FASEB journal, 2022-05, Vol.36 (S1), p.n/a

2022

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Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors

Current opinion in pharmacology, 2023-10, Vol.72, p.102364-102364, Article 102364

2023

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Membrane mimetic-dependence of GPCR energy landscapes

Structure (London), 2024-05, Vol.32 (5), p.523-535.e5

2024

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Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines

Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling

Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor

Anionic phospholipids control mechanisms of GPCR-G protein recognition

Structural biology of human GPCR drugs and endogenous ligands - insights from NMR spectroscopy

β2-Adrenergic Receptor Conformational Response to Fusion Protein in the Third Intracellular Loop

Spectroscopy by Integration of Frequency and Time Domain Information for Fast Acquisition of High-Resolution Dark Spectra

GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures

Production of a Human Histamine Receptor for NMR Spectroscopy in Aqueous Solutions

Production of human A2AAR in lipid nanodiscs for 19F-NMR and single-molecule fluorescence spectroscopy

Magic Angle Spinning Nuclear Magnetic Resonance Characterization of Voltage-Dependent Anion Channel Gating in Two-Dimensional Lipid Crystalline Bilayers

Single-molecule visualization of human A2A adenosine receptor activation by a G protein and constitutively activating mutations

Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR

Extrinsic Tryptophans as NMR Probes of Allosteric Coupling in Membrane Proteins: Application to the A2A Adenosine Receptor

A comparative study of interfacial environments in lipid nanodiscs and vesicles

A2A Adenosine Receptor Partial Agonism Related to Structural Rearrangements in an Activation Microswitch

Selectively dispersed isotope labeling for protein structure determination by magic angle spinning NMR

Proton Assisted Recoupling at High Spinning Frequencies

Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition

NMR Spectroscopic Studies of Ion Channels in Lipid Bilayers: Sample Preparation Strategies Exemplified by the Voltage Dependent Anion Channel

Radio frequency-driven recoupling at high magic-angle spinning frequencies: Homonuclear recoupling sans heteronuclear decoupling

Interaction networks within disease-associated GαS variants characterized by an integrative biophysical approach

New Insights into the Structure‐Function Relationships of G Proteins Containing Disease‐Associated Mutations

Illuminating GPCR signaling mechanisms by NMR spectroscopy with stable-isotope labeled receptors

Membrane mimetic-dependence of GPCR energy landscapes

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