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Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo

Proceedings of the National Academy of Sciences - PNAS, 2003-04, Vol.100 (7), p.4162-4167

2003

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Amyloid-β Peptide Levels in Brain Are Inversely Correlated with Insulysin Activity Levels in vivo

Proceedings of the National Academy of Sciences - PNAS, 2003-05, Vol.100 (10), p.6221-6226

2003

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Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease

Drug Discovery Today, 2001-10, Vol.6 (20), p.1049-1055

2001

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The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

Nature neuroscience, 2001-09, Vol.4 (9), p.887-893

2001

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Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

The Journal of biological chemistry, 2001-07, Vol.276 (27), p.24540-24548

2001

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High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid β peptide (Aβ)

Journal of neuroscience methods, 2001-07, Vol.108 (2), p.171-179

2001

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The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Neuron (Cambridge, Mass.), 2004-10, Vol.44 (2), p.227-238

2004

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Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease

BBA - Molecular Basis of Disease, 2000-07, Vol.1502 (1), p.172-187

2000

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Altered Metabolism of Familial Alzheimer's Disease-Linked Amyloid Precursor Protein Variants in Yeast Artificial Chromosome Transgenic Mice

Human molecular genetics, 1997-09, Vol.6 (9), p.1535-1541

1997

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Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1

The Journal of biological chemistry, 2003-12, Vol.278 (51), p.51100-51107

2003

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Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy

The FASEB journal, 2005-09, Vol.19 (11), p.1549-1551

2005

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Amyloid β Protein Starting Pyroglutamate at Position 3 Is a Major Component of the Amyloid Deposits in the Alzheimer's Disease Brain

Biochemical and biophysical research communications, 2000-09, Vol.276 (2), p.422-427

2000

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Behavioral and neurobiological markers of Alzheimer’s disease in Ts65Dn mice: effects of estrogen

Neurobiology of aging, 2004-08, Vol.25 (7), p.873-884

2004

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Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)

The Journal of biological chemistry, 1995-03, Vol.270 (13), p.7013-7016

1995

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gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

The Journal of biological chemistry, 1999-04, Vol.274 (17), p.11914-11923

1999

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A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

Human molecular genetics, 1997-11, Vol.6 (12), p.2087-2089

1997

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Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion

Neurobiology of disease, 1998-10, Vol.5 (4), p.281-286

1998

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Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

The FASEB journal, 2001-01, Vol.15 (1), p.16-18

2001

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Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy

The FASEB journal, 2007-08, Vol.21 (10), p.2520-2527

2007

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Reduction of A beta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

The FASEB journal, 2001-01, Vol.15 (1), p.16-18

2001

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Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

The Journal of biological chemistry, 2003-01, Vol.278 (4), p.2081-2084

2003

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Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Neurobiology of disease, 1998-08, Vol.5 (2), p.107-116

1998

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Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

The EMBO journal, 2006-01, Vol.25 (2), p.420-431

2006

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Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

The American journal of pathology, 2004-04, Vol.164 (4), p.1425-1434

2004

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Natural Product Extracts that Reduce Accumulation of the Alzheimer's Amyloid beta Peptide: Selective Reduction in A beta 42

Journal of molecular neuroscience, 2002-10, Vol.19 (1-2), p.129-133

2002

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Insulin-Degrading Enzyme Regulates the Levels of Insulin, Amyloid β-Protein, and the β-Amyloid Precursor Protein Intracellular Domain in vivo

Amyloid-β Peptide Levels in Brain Are Inversely Correlated with Insulysin Activity Levels in vivo

Cholesterol modulation as an emerging strategy for the treatment of Alzheimer's disease

The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Aβ protofibril formation

Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme

High throughput screens for the identification of compounds that alter the accumulation of the Alzheimer's amyloid β peptide (Aβ)

The ACAT Inhibitor CP-113,818 Markedly Reduces Amyloid Pathology in a Mouse Model of Alzheimer's Disease

Biochemical detection of Aβ isoforms: implications for pathogenesis, diagnosis, and treatment of Alzheimer’s disease

Altered Metabolism of Familial Alzheimer's Disease-Linked Amyloid Precursor Protein Variants in Yeast Artificial Chromosome Transgenic Mice

Generation of the β-Amyloid Peptide and the Amyloid Precursor Protein C-terminal Fragment γ Are Potentiated by FE65L1

Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy

Amyloid β Protein Starting Pyroglutamate at Position 3 Is a Major Component of the Amyloid Deposits in the Alzheimer's Disease Brain

Behavioral and neurobiological markers of Alzheimer’s disease in Ts65Dn mice: effects of estrogen

Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)

gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

A new pathogenic mutation in the APP gene (I716V) increases the relative proportion of A beta 42(43)

Flemish and Dutch Mutations in Amyloid β Precursor Protein Have Different Effects on Amyloid β Secretion

Reduction of Abeta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

Single-dose intracerebroventricular administration of galactocerebrosidase improves survival in a mouse model of globoid cell leukodystrophy

Reduction of A beta accumulation in the Tg2576 animal model of Alzheimer's disease after oral administration of the phosphatidyl-inositol kinase inhibitor wortmannin

Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme

Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development

Partial Loss-of-Function Mutations in Insulin-Degrading Enzyme that Induce Diabetes also Impair Degradation of Amyloid β-Protein

Natural Product Extracts that Reduce Accumulation of the Alzheimer's Amyloid beta Peptide: Selective Reduction in A beta 42

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