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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

BMC biology, 2012-03, Vol.10 (1), p.29-29, Article 29

2012

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Metastasis: recent discoveries and novel treatment strategies

The Lancet (British edition), 2007-05, Vol.369 (9574), p.1742-1757

2007

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Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells

Cellular signalling, 2017-09, Vol.37, p.12-30

2017

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Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells

BMC cancer, 2014-12, Vol.14 (1), p.955-955, Article 955

2014

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microRNA DNA methylation signature for human cancer metastasis

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (36), p.13556-13561

2008

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Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening

Journal of medicinal chemistry, 2016-10, Vol.59 (20), p.9337-9349

2016

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Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling

Journal of clinical immunology, 2012-10, Vol.32 (5), p.1059-1070

2012

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Tumor spheroid-based migration assays for evaluation of therapeutic agents

Methods in molecular biology (Clifton, N.J.), 2013, Vol.986, p.253

2013

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Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

Clinical cancer research, 2013-11, Vol.19 (21), p.5940-5951

2013

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Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1078-1101

2016

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HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells

BMC cancer, 2022-05, Vol.22 (1), p.578-578, Article 578

2022

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HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

Clinical cancer research, 2018-05, Vol.24 (10), p.2395-2407

2018

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High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Molecular cancer therapeutics, 2019-10, Vol.18 (10), p.1696-1707

2019

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Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Molecular cancer therapeutics, 2009-07, Vol.8 (7), p.1725-1738

2009

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Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Journal of medicinal chemistry, 2015-02, Vol.58 (4), p.1717-1735

2015

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Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger

The Journal of biological chemistry, 2015-07, Vol.290 (30), p.18412-18428

2015

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High ASMA+ Fibroblasts and Low Cytoplasmic HMGB1+ Breast Cancer Cells Predict Poor Prognosis

Clinical breast cancer, 2017-10, Vol.17 (6), p.441-452.e2

2017

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Three-dimensional (3D) tumor spheroid invasion assay

Journal of visualized experiments, 2015-05 (99), p.e52686-e52686

2015

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Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Journal of medicinal chemistry, 2013-12, Vol.56 (24), p.10045-10065

2013

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Ca2+ Influx through Reverse Mode Na+/Ca2+ Exchange Is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells

The Journal of biological chemistry, 2011-11, Vol.286 (44), p.37919-37931

2011

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Journal of medicinal chemistry, 2017-01, Vol.60 (1), p.180-201

2017

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Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

Bioorganic & medicinal chemistry letters, 2016-03, Vol.26 (5), p.1443-1451

2016

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Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation

Metastasis: recent discoveries and novel treatment strategies

Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells

Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells

microRNA DNA methylation signature for human cancer metastasis

Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening

Dual Targeting of ErbB2 and MUC1 in Breast Cancer Using Chimeric Antigen Receptors Engineered to Provide Complementary Signaling

Tumor spheroid-based migration assays for evaluation of therapeutic agents

Dual Blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) Pathways Synergistically Inhibits Rhabdomyosarcoma Cell Growth In Vitro and In Vivo

Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19

HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells

Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study

HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target

4,5-Diarylisoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers

Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941

Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen

Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger

High ASMA+ Fibroblasts and Low Cytoplasmic HMGB1+ Breast Cancer Cells Predict Poor Prognosis

Three-dimensional (3D) tumor spheroid invasion assay

Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases

Structure-Based Design of Orally Bioavailable 1H‑Pyrrolo[3,2‑c]pyridine Inhibitors of Mitotic Kinase Monopolar Spindle 1 (MPS1)

Ca2+ Influx through Reverse Mode Na+/Ca2+ Exchange Is Critical for Vascular Endothelial Growth Factor-mediated Extracellular Signal-regulated Kinase (ERK) 1/2 Activation and Angiogenic Functions of Human Endothelial Cells

Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen

Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore

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