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Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

Current pharmaceutical design, 2010-09, Vol.16 (27), p.2950-2960

2010

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Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

Osteoporosis international, 2008-06, Vol.19 (6), p.733-759

2008

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The relationship between the chemistry and biological activity of the bisphosphonates

Bone (New York, N.Y.), 2011-07, Vol.49 (1), p.20-33

2011

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Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice

Bone (New York, N.Y.), 2019-06, Vol.123, p.115-128

2019

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Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite

Bone (New York, N.Y.), 2006-05, Vol.38 (5), p.617-627

2006

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Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1985

2023

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Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

Journal of bone and mineral research, 2006-05, Vol.21 (5), p.684-694

2006

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The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7829-7834

2006

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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Journal of bone and mineral research, 2012-04, Vol.27 (4), p.835-847

2012

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Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases

Cancer research (Chicago, Ill.), 2000-06, Vol.60 (11), p.2949-2954

2000

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How Do Bisphosphonates Inhibit Bone Metastasis In Vivo

Neoplasia (New York, N.Y.), 2010-07, Vol.12 (7), p.571-578

2010

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Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates

The Journal of pharmacology and experimental therapeutics, 2001-02, Vol.296 (2), p.235

2001

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The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)

Journal of bone and mineral research, 2017-09, Vol.32 (9), p.1860-1869

2017

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Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

Pharmaceutics, 2018-09, Vol.10 (3), p.154

2018

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Differences between bisphosphonates in binding affinities for hydroxyapatite

Journal of biomedical materials research. Part B, Applied biomaterials, 2010-01, Vol.92B (1), p.149-155

2010

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Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

Bone Research, 2024-09, Vol.12 (1), p.52, Article 52

2024

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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

eLife, 2021-12, Vol.10

2021

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Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Bioconjugate chemistry, 2016-02, Vol.27 (2), p.329-340

2016

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Bisphosphonate use in the horse: what is good and what is not?

BMC veterinary research, 2019-06, Vol.15 (1), p.211-211, Article 211

2019

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Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates

Bone (New York, N.Y.), 2003-11, Vol.33 (5), p.805-811

2003

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Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Annals of the New York Academy of Sciences, 2007-11, Vol.1117 (1), p.209-257

2007

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Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi

Frontiers in cellular and infection microbiology, 2022-06, Vol.12, p.910970

2022

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Bisphosphonates and cancer-induced bone disease : Beyond their antiresorptive activity

Cancer research (Chicago, Ill.), 2005-06, Vol.65 (12), p.4971-4974

2005

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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Bone Research, 2023-10, Vol.11 (1), p.51-51, Article 51

2023

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Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

Bone (New York, N.Y.), 2005-09, Vol.37 (3), p.349-358

2005

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Bisphosphonates: molecular mechanisms of action and effects on bone cells, monocytes and macrophages

Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

The relationship between the chemistry and biological activity of the bisphosphonates

Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice

Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite

Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates

Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases

How Do Bisphosphonates Inhibit Bone Metastasis In Vivo

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

Differences between bisphosphonates in binding affinities for hydroxyapatite

Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Bisphosphonate use in the horse: what is good and what is not?

Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates

Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi

Bisphosphonates and cancer-induced bone disease : Beyond their antiresorptive activity

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

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