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The relationship between the chemistry and biological activity of the bisphosphonates

Bone (New York, N.Y.), 2011-07, Vol.49 (1), p.20-33

2011

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Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice

Bone (New York, N.Y.), 2019-06, Vol.123, p.115-128

2019

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Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates

International journal of molecular sciences, 2023-01, Vol.24 (3), p.1985

2023

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The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (20), p.7829-7834

2006

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Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Journal of bone and mineral research, 2012-04, Vol.27 (4), p.835-847

2012

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Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

Journal of bone and mineral research, 2006-05, Vol.21 (5), p.684-694

2006

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Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

Pharmaceutics, 2018-09, Vol.10 (3), p.154

2018

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Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

Bone Research, 2024-09, Vol.12 (1), p.52, Article 52

2024

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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

eLife, 2021-12, Vol.10

2021

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Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Bioconjugate chemistry, 2016-02, Vol.27 (2), p.329-340

2016

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Bisphosphonate use in the horse: what is good and what is not?

BMC veterinary research, 2019-06, Vol.15 (1), p.211-211, Article 211

2019

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How Do Bisphosphonates Inhibit Bone Metastasis In Vivo

Neoplasia (New York, N.Y.), 2010-07, Vol.12 (7), p.571-578

2010

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The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)

Journal of bone and mineral research, 2017-09, Vol.32 (9), p.1860-1869

2017

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Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi

Frontiers in cellular and infection microbiology, 2022-06, Vol.12, p.910970

2022

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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

Bone Research, 2023-10, Vol.11 (1), p.51-51, Article 51

2023

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History of risedronate

Bone (New York, N.Y.), 2020-08, Vol.137, p.115407-115407, Article 115407

2020

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Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

Antibiotics (Basel), 2021-06, Vol.10 (6), p.732

2021

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A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

JBMR plus, 2021-04, Vol.5 (4), p.e10476-n/a

2021

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Bisphosphonates in veterinary medicine: The new horizon for use

Bone (New York, N.Y.), 2021-01, Vol.142, p.115711-115711, Article 115711

2021

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Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

Communications medicine, 2022-09, Vol.2 (1), p.112-112, Article 112

2022

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Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use

Bone (New York, N.Y.), 2022-03, Vol.156, p.116289-116289, Article 116289

2022

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Targeting anti-cancer agents to bone using bisphosphonates

Bone (New York, N.Y.), 2020-09, Vol.138, p.115492-115492, Article 115492

2020

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Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid

Journal of medicinal chemistry, 2010-05, Vol.53 (9), p.3454-3464

2010

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Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

JBMR plus, 2021-07, Vol.5 (7), p.e10492-n/a

2021

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Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

Bone (New York, N.Y.), 2005-09, Vol.37 (3), p.349-358

2005

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The relationship between the chemistry and biological activity of the bisphosphonates

Rescue bisphosphonate treatment of alveolar bone improves extraction socket healing and reduces osteonecrosis in zoledronate-treated mice

Real-Time Impedance-Based Monitoring of the Growth and Inhibition of Osteomyelitis Biofilm Pathogen Staphylococcus aureus Treated with Novel Bisphosphonate-Fluoroquinolone Antimicrobial Conjugates

The Molecular Mechanism of Nitrogen-Containing Bisphosphonates as Antiosteoporosis Drugs

Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo

Inhibition of Protein Prenylation by Bisphosphonates Causes Sustained Activation of Rac, Cdc42, and Rho GTPases

Synthesis of a Bone-Targeted Bortezomib with In Vivo Anti-Myeloma Effects in Mice

Hydroxychloroquine and a low antiresorptive activity bisphosphonate conjugate prevent and reverse ovariectomy-induced bone loss in mice through dual antiresorptive and anabolic effects

Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

Bisphosphonate use in the horse: what is good and what is not?

How Do Bisphosphonates Inhibit Bone Metastasis In Vivo

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1‐Fluoro‐2‐(Imidazo‐[1,2‐α]Pyridin‐3‐yl)‐Ethyl‐Bisphosphonate)

Efficacy of Bisphosphonate-Conjugated Sitafloxacin in a Murine Model of S. aureus Osteomyelitis: Evidence of "Target & Release" Kinetics and Killing of Bacteria Within Canaliculi

Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis

History of risedronate

Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

Bisphosphonates in veterinary medicine: The new horizon for use

Fluorescent risedronate analogue 800CW-pRIS improves tooth extraction-associated abnormal wound healing in zoledronate-treated mice

Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use

Targeting anti-cancer agents to bone using bisphosphonates

Synthesis, Chiral High Performance Liquid Chromatographic Resolution and Enantiospecific Activity of a Potent New Geranylgeranyl Transferase Inhibitor, 2-Hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid

Reply to: A Bisphosphonate With a Low Hydroxyapatite Binding Affinity Prevents Bone Loss in Mice After Ovariectomy and Reverses Rapidly With Treatment Cessation

Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

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