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Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates

Bone (New York, N.Y.), 2003-11, Vol.33 (5), p.805-811

2003

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Development of Bone-Targeted Bortezomib to Treat Multiple Myeloma

Clinical lymphoma, myeloma and leukemia, 2017-02, Vol.17 (1), p.e87-e88

2017

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Alendronate and ibandronate affect osteoclast formation and size differently from risedronate and zoledronate

Bone (New York, N.Y.), 2011-05, Vol.48, p.S220-S220

2011

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Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces

Bone (New York, N.Y.), 2012-05, Vol.50, p.S55-S55

2012

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Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite

Bone (New York, N.Y.), 2006-05, Vol.38 (5), p.617-627

2006

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Characterisation of the interaction of nitrogen-containing bisphosphonates with human farnesyl pyrophosphate synthase (FPPS) using mutants of the lysine 200 and phenylalanine 239 active site residues

Bone (New York, N.Y.), 2010-06, Vol.47, p.S220-S221

2010

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Use of hydroxyapatite-column chromatography combined with mass spectrometric analysis to assess the relative bone mineral-binding affinities of bisphosphonates at different PHS

Bone (New York, N.Y.), 2010-06, Vol.47, p.S199-S200

2010

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Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH2

Bioorganic & medicinal chemistry letters, 2003-08, Vol.13 (16), p.2647-2650

2003

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Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase

Bone (New York, N.Y.), 2009-06, Vol.44, p.S323-S323

2009

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The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces

Bone (New York, N.Y.), 2009-05, Vol.44, p.S57-S57

2009

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The direct antitumor activity of bisphosphonates in vivo depends on their bone mineral affinity

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.45-45

2006

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Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo

Bone (New York, N.Y.), 2009-06, Vol.44, p.S430-S431

2009

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Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH 2) 3CO-His- d-Phe-Arg-Trp-NH 2]. An additional binding site within the human melanocortin receptor 1?

Bioorganic & medicinal chemistry letters, 2004-08, Vol.14 (15), p.3997-4000

2004

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End-capping of the modified melanocortin tetrapeptide (p-Cl)Phe-D-Phe-Arg-Trp-NH2 as a route to hMC4R agonists

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4839-4842

2004

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Structure-activity relationships of bisphosphonate analogues

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.46-46

2006

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Target enzyme specificity, potency and potential lack of side-effects of novel phosphonocarboxylate analogues of bisphosphonates

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.46-47

2006

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Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

Bone (New York, N.Y.), 1998-11, Vol.23 (5), p.437-442

1998

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A computational model explains bisphosphonate binding affinity differences on hydroxyapatite

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.48-49

2006

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Refining the use of hydroxyapatite column chromatography to reveal differences in relative binding affinities of bisphosphonates

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.55-55

2006

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Anti-nociceptive effects of the bisphosphonate risedronate in a syngeneic mouse model of bone cancer pain

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.51-51

2006

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Substitution of the R1 hydroxyl and C1 phosphate of risedronate produces differences in elution profiles on hydroxyapatite ceramic chromatographic columns

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.63-64

2006

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Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.49-49

2006

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Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.47-48

2006

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End-capping of the modified melanocortin tetrapeptide ( p-Cl)Phe- D-Phe-Arg-Trp-NH 2 as a route to hMC4R agonists

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4839-4842

2004

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Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase

Bone (New York, N.Y.), 2006-03, Vol.38 (3), p.53-53

2006

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Differentiating the mechanisms of antiresorptive action of nitrogen containing bisphosphonates

Development of Bone-Targeted Bortezomib to Treat Multiple Myeloma

Alendronate and ibandronate affect osteoclast formation and size differently from risedronate and zoledronate

Effects of alendronate and risedronate on bone material properties in actively forming trabecular bone surfaces

Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite

Characterisation of the interaction of nitrogen-containing bisphosphonates with human farnesyl pyrophosphate synthase (FPPS) using mutants of the lysine 200 and phenylalanine 239 active site residues

Use of hydroxyapatite-column chromatography combined with mass spectrometric analysis to assess the relative bone mineral-binding affinities of bisphosphonates at different PHS

Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH2

Evidence for the involvement of the threonine 201 side-chain in the interaction of nitrogen-containing bisphosphonates with farnesyl pyrophosphate synthase

The differential distribution in vivo of fluorescently-labeled bisphosphonate analogues with different mineral affinity to bone surfaces

The direct antitumor activity of bisphosphonates in vivo depends on their bone mineral affinity

Bone mineral affinity influences the distribution of a bisphosphonate and a lower affinity analogue in vivo

Analogs of sub-nanomolar hMC1R agonist LK-184 [Ph(CH 2) 3CO-His- d-Phe-Arg-Trp-NH 2]. An additional binding site within the human melanocortin receptor 1?

End-capping of the modified melanocortin tetrapeptide (p-Cl)Phe-D-Phe-Arg-Trp-NH2 as a route to hMC4R agonists

Structure-activity relationships of bisphosphonate analogues

Target enzyme specificity, potency and potential lack of side-effects of novel phosphonocarboxylate analogues of bisphosphonates

Binding and antiresorptive properties of heterocycle-containing bisphosphonate analogs: structure-activity relationships

A computational model explains bisphosphonate binding affinity differences on hydroxyapatite

Refining the use of hydroxyapatite column chromatography to reveal differences in relative binding affinities of bisphosphonates

Anti-nociceptive effects of the bisphosphonate risedronate in a syngeneic mouse model of bone cancer pain

Substitution of the R1 hydroxyl and C1 phosphate of risedronate produces differences in elution profiles on hydroxyapatite ceramic chromatographic columns

Human farnesyl diphosphate synthase crystal structures with active and inactive bisphosphonates

Investigations into the kinetic mechanism of inhibition of farnesyl diphosphate synthase by nitrogen containing bisphosphonates

End-capping of the modified melanocortin tetrapeptide ( p-Cl)Phe- D-Phe-Arg-Trp-NH 2 as a route to hMC4R agonists

Crystal structures and molecular interactions of risedronate and zoledronate with human farnesyl diphosphate synthase

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