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Applications of Fluorine in Medicinal Chemistry

Journal of medicinal chemistry, 2015-11, Vol.58 (21), p.8315-8359

2015

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Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole−Aniline Coupling: Psychotrimine and Kapakahines B and F

Journal of the American Chemical Society, 2010-05, Vol.132 (20), p.7119-7137

2010

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A simple method for the direct arylation of indoles

Tetrahedron, 2009-04, Vol.65 (16), p.3149-3154

2009

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Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity

Bioorganic & medicinal chemistry letters, 2018-11, Vol.28 (21), p.3463-3471

2018

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Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Xenobiotica, 2018-12, Vol.48 (12), p.1215-1226

2018

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Same Book, Different Bookmarks: The Development and Preliminary Validation of the Bible Verse Selection Task as a Measure of Christian Fundamentalism

Journal of psychology and theology, 2019-12, Vol.47 (4), p.278-295

2019

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Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane

Drug metabolism and disposition, 2016-08, Vol.44 (8), p.1332-1340

2016

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Identification of a novel series of potent HCV NS5B Site I inhibitors

Bioorganic & medicinal chemistry letters, 2014-04, Vol.24 (8), p.1993-1997

2014

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A Proposal for the Mechanism-of-Action of Diazoparaquinone Natural Products

Journal of the American Chemical Society, 2005-11, Vol.127 (44), p.15344-15345

2005

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Studies on the Mechanism of Action of Prekinamycin, a Member of the Diazoparaquinone Family of Natural Products: Evidence for Both sp2 Radical and Orthoquinonemethide Intermediates

Journal of the American Chemical Society, 2006-09, Vol.128 (38), p.12562-12573

2006

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Diazonamide Synthesis Studies: Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality

Organic letters, 2002-10, Vol.4 (20), p.3525-3528

2002

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An oral androgen receptor RIPTAC for prostate cancer

Journal of clinical oncology, 2023-02, Vol.41 (6_suppl), p.184-184

2023

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Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors

Bioorganic & medicinal chemistry, 2022-08, Vol.67, p.116833-116833, Article 116833

2022

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Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor

ACS medicinal chemistry letters, 2022-06, Vol.13 (6), p.972-980

2022

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Supergene Mineralization of the Continental Pit, Butte, Silver Bow County, Montana

Eastman, Kyle

2017

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A simple method for the direct arylation of indoles: Recent Advances in Synthetic Methodology: Development and Applications

Tetrahedron, 2009, Vol.65 (16)

2009

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Abstract 1629: Prostate cancer RIPTAC™ therapeutics demonstrate activity in preclinical models of Enzalutamide-resistant prostate cancer

Cancer research (Chicago, Ill.), 2023-04, Vol.83 (7_Supplement), p.1629-1629

2023

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Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor

ACS medicinal chemistry letters, 2017-07, Vol.8 (7), p.771-774

2017

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ChemInform Abstract: Widman-Stoermer Cinnoline Synthesis

ChemInform, 2012-05, Vol.43 (19), p.no-no

Eastman, Kyle J.

2012

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ChemInform Abstract: Robinson-Schoepf Condensation

ChemInform, 2012-05, Vol.43 (19), p.no-no

Eastman, Kyle J.

2012

Volltextzugriff (PDF)

Studies on the Mechanism of Action of Prekinamycin, a Member of the Diazoparaquinone Family of Natural Products: Evidence for Both sp 2 Radical and Orthoquinonemethide Intermediates

Journal of the American Chemical Society, 2006-09, Vol.128 (38), p.12562-12573

2006

Volltextzugriff (PDF)

Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products : Evidence for both sp2radical and orthoquinonemethide intermediates

Journal of the American Chemical Society, 2006, Vol.128 (38), p.12562-12573

2006

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Part I. Studies toward the synthesis of diazonamide A. Part II. A proposal for the mechanism-of-action of diazoparaquinone natural products and studies toward the synthesis of kinamycin F

Eastman, Kyle Joseph

2006

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ChemInform Abstract: A Simple Method for the Direct Arylation of Indoles

ChemInform, 2009-08, Vol.40 (33), p.no-no

2009

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Chemistry in the Pharmaceutical Industry

Handbook of Industrial Chemistry and Biotechnology, 2013, p.391-418

2013

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Applications of Fluorine in Medicinal Chemistry

Scalable Total Syntheses of N-Linked Tryptamine Dimers by Direct Indole−Aniline Coupling: Psychotrimine and Kapakahines B and F

A simple method for the direct arylation of indoles

Ferrocene-based inhibitors of hepatitis C virus replication that target NS5A with low picomolar in vitro antiviral activity

Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors

Same Book, Different Bookmarks: The Development and Preliminary Validation of the Bible Verse Selection Task as a Measure of Christian Fundamentalism

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane

Identification of a novel series of potent HCV NS5B Site I inhibitors

A Proposal for the Mechanism-of-Action of Diazoparaquinone Natural Products

Studies on the Mechanism of Action of Prekinamycin, a Member of the Diazoparaquinone Family of Natural Products: Evidence for Both sp2 Radical and Orthoquinonemethide Intermediates

Diazonamide Synthesis Studies: Use of Negishi Coupling to Fashion Diazonamide-Related Biaryls with Defined Axial Chirality

An oral androgen receptor RIPTAC for prostate cancer

Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors

Discovery and Preclinical Profiling of GSK3839919, a Potent HIV‑1 Allosteric Integrase Inhibitor

Supergene Mineralization of the Continental Pit, Butte, Silver Bow County, Montana

A simple method for the direct arylation of indoles: Recent Advances in Synthetic Methodology: Development and Applications

Abstract 1629: Prostate cancer RIPTAC™ therapeutics demonstrate activity in preclinical models of Enzalutamide-resistant prostate cancer

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor

ChemInform Abstract: Widman-Stoermer Cinnoline Synthesis

ChemInform Abstract: Robinson-Schoepf Condensation

Studies on the Mechanism of Action of Prekinamycin, a Member of the Diazoparaquinone Family of Natural Products: Evidence for Both sp 2 Radical and Orthoquinonemethide Intermediates

Studies on the mechanism of action of prekinamycin, a member of the diazoparaquinone family of natural products : Evidence for both sp2radical and orthoquinonemethide intermediates

Part I. Studies toward the synthesis of diazonamide A. Part II. A proposal for the mechanism-of-action of diazoparaquinone natural products and studies toward the synthesis of kinamycin F

ChemInform Abstract: A Simple Method for the Direct Arylation of Indoles

Chemistry in the Pharmaceutical Industry

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