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A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

Annals of neurology, 2014-04, Vol.75 (4), p.550-562

2014

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Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.754-762

2013

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PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

Current drug metabolism, 2011-10, Vol.12 (8), p.774-792

2011

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GABAA receptor modulation by piperine and a non-TRPV1 activating derivative

Biochemical pharmacology, 2013-06, Vol.85 (12), p.1827-1836

2013

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Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

Nucleic acids research, 2014-11, Vol.42 (20), p.12555-12569

2014

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Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Frontiers in physiology, 2020-07, Vol.11, p.911-911

2020

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Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

Bioorganic & medicinal chemistry, 2010-08, Vol.18 (15), p.5489-5497

2010

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Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides

PloS one, 2016, Vol.11 (1), p.e0145615

2016

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Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain Barrier

Journal of medicinal chemistry, 2009-10, Vol.52 (19), p.6073-6082

2009

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Foam cell specific LXRα ligand

PloS one, 2013-02, Vol.8 (2), p.e57311-e57311

2013

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Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors

Chemical and Pharmaceutical Bulletin, 2007, Vol.55(1), pp.64-71

2007

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Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Oncology reports, 2006-09, Vol.16 (3), p.617-624

2006

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Resveratrol blocks Akt activation in angiotensin II-or EGF-stimulated vascular smooth muscle cells in a redox-independent manner

Cardiovascular research, 2011-04, Vol.90 (1), p.140-147

2011

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Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches

Pharmacology & therapeutics (Oxford), 2020-01, Vol.205, p.107422, Article 107422

2020

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Functional characterization of novel bumetanide derivatives for epilepsy treatment

Neuropharmacology, 2020-01, Vol.162, p.107754, Article 107754

2020

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Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein

Current topics in medicinal chemistry, 2010-12, Vol.10 (17), p.1769-1774

2010

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Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines

Anticancer research, 2007-09, Vol.27 (5A), p.3459-3464

2007

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Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

Neuropharmacology, 2017-05, Vol.117, p.182-194

2017

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Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein

Bioorganic & medicinal chemistry, 2014-04, Vol.22 (7), p.2311-2319

2014

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Effects of Novel Synthesized Pyridothiazines on Various Guinea Pig Heart Muscle Preparations

Biological and Pharmaceutical Bulletin, 2004, Vol.27(9), pp.1364-1370

2004

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The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice

Epilepsia (Copenhagen), 2016-05, Vol.57 (5), p.698-705

2016

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Impact of resveratrol analogues on a 3D in vitro model of human skin

Experimental gerontology, 2017-08, Vol.94, p.116-117

2017

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The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Investigational new drugs, 2019-10, Vol.37 (5), p.849-864

2019

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Synthesis of 1,2-Disubstituted Imidazoles via Cross-Coupling and Substitution Reactions

Heterocycles, 2005-11, Vol.65 (11), p.2721

2005

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A Novel Na+-K+-Cl− Cotransporter 1 Inhibitor STS66 Reduces Brain Damage in Mice After Ischemic Stroke

Stroke (1970), 2019-04, Vol.50 (4), p.1021-1025

2019

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A novel prodrug-based strategy to increase effects of bumetanide in epilepsy

Tariquidar and elacridar are dose-dependently transported by P-glycoprotein and Bcrp at the blood-brain barrier: a small-animal positron emission tomography and in vitro study

PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo

GABAA receptor modulation by piperine and a non-TRPV1 activating derivative

Resveratrol post-transcriptionally regulates pro-inflammatory gene expression via regulation of KSRP RNA binding activity

Role of NKCC1 Activity in Glioma K+ Homeostasis and Cell Growth: New Insights With the Bumetanide-Derivative STS66

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

Novel Promising Estrogenic Receptor Modulators: Cytotoxic and Estrogenic Activity of Benzanilides and Dithiobenzanilides

Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain Barrier

Foam cell specific LXRα ligand

Synthesis of Novel Curcumin Analogues and Their Evaluation as Selective Cyclooxygenase-1 (COX-1) Inhibitors

Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines

Resveratrol blocks Akt activation in angiotensin II-or EGF-stimulated vascular smooth muscle cells in a redox-independent manner

Impaired chloride homeostasis in epilepsy: Molecular basis, impact on treatment, and current treatment approaches

Functional characterization of novel bumetanide derivatives for epilepsy treatment

Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein

Novel Resveratrol Derivatives Induce Apoptosis and Cause Cell Cycle Arrest in Prostate Cancer Cell Lines

Multiple blood-brain barrier transport mechanisms limit bumetanide accumulation, and therapeutic potential, in the mammalian brain

Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein

Effects of Novel Synthesized Pyridothiazines on Various Guinea Pig Heart Muscle Preparations

The bumetanide prodrug BUM5, but not bumetanide, potentiates the antiseizure effect of phenobarbital in adult epileptic mice

Impact of resveratrol analogues on a 3D in vitro model of human skin

The role of oxidative stress in 63 T-induced cytotoxicity against human lung cancer and normal lung fibroblast cell lines

Synthesis of 1,2-Disubstituted Imidazoles via Cross-Coupling and Substitution Reactions

A Novel Na+-K+-Cl− Cotransporter 1 Inhibitor STS66 Reduces Brain Damage in Mice After Ischemic Stroke

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