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Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

Proceedings of the National Academy of Sciences - PNAS, 2010-05, Vol.107 (18), p.8129-8134

2010

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Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors

Cell stem cell, 2009-01, Vol.4 (1), p.16-19

2009

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A chemical platform for improved induction of human iPSCs

Nature methods, 2009-11, Vol.6 (11), p.805-808

2009

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Generation of Human‐Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2

Stem cells (Dayton, Ohio), 2009-12, Vol.27 (12), p.2992-3000

2009

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Long-Term Self-Renewal and Directed Differentiation of Human Embryonic Stem Cells in Chemically Defined Conditions

Proceedings of the National Academy of Sciences - PNAS, 2006-05, Vol.103 (18), p.6907-6912

2006

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Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance

Cell reports (Cambridge), 2015-02, Vol.10 (7), p.1149-1157

2015

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Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies

Transplantation, 2009-04, Vol.87 (7), p.983-991

2009

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Progenitor cell domains in the developing and adult pancreas

Cell cycle (Georgetown, Tex.), 2011-06, Vol.10 (12), p.1921-1927

2011

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ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis

Proceedings of the National Academy of Sciences - PNAS, 2015-03, Vol.112 (9), p.2699-2704

2015

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Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas

Nature medicine, 2006-03, Vol.12 (3), p.310-316

2006

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Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic β-cells

Proceedings of the National Academy of Sciences - PNAS, 2009-05, Vol.106 (18), p.7531-7536

2009

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The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells

PloS one, 2012-06, Vol.7 (6), p.e38721-e38721

2012

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A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function

Diabetes (New York, N.Y.), 2002-12, Vol.51 (12), p.3435-3439

2002

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Limited Capacity of Human Adult Islets Expanded In Vitro to Redifferentiate Into Insulin-Producing β-Cells

Diabetes (New York, N.Y.), 2007-03, Vol.56 (3), p.703-708

2007

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The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma

Molecular cancer research, 2011-06, Vol.9 (6), p.782-790

2011

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β-cell replication and islet neogenesis following partial pancreatectomy

Islets, 2011-07, Vol.3 (4), p.188-195

2011

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Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

Islets, 2011-11, Vol.3 (6), p.358-366

2011

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Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1

The Journal of biological chemistry, 2023-08, Vol.299 (8), p.104803-104803, Article 104803

2023

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Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β‐cell, regeneration

Physiological reports, 2014-09, Vol.2 (9), p.e12131-n/a

2014

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Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

Development (Cambridge), 2011-02, Vol.138 (4), p.653-665

2011

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Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

Stem cell research, 2014-05, Vol.12 (3), p.807-814

2014

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Pancreatic β‐Cell Neogenesis by Direct Conversion from Mature α‐Cells

Stem cells (Dayton, Ohio), 2010-09, Vol.28 (9), p.1630-1638

2010

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Efficient [beta]-Cell Regeneration by a Combination of Neogenesis and Replication Following [beta]-Cell Ablation and Reversal of Pancreatic Duct Ligation

Stem cells (Dayton, Ohio), 2013-11, Vol.31 (11), p.2388-2395

2013

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Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation

Islets, 2018-11, Vol.10 (6), p.201-212

2018

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Loss of TRB3 Alters Dynamics of MLK3-JNK Signaling and Inhibits Cytokine-activated Pancreatic Beta Cell Death

The Journal of biological chemistry, 2014-10, Vol.289 (43), p.29994-30004

2014

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Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules

Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors

A chemical platform for improved induction of human iPSCs

Generation of Human‐Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2

Long-Term Self-Renewal and Directed Differentiation of Human Embryonic Stem Cells in Chemically Defined Conditions

Feedback Inhibition of CREB Signaling Promotes Beta Cell Dysfunction in Insulin Resistance

Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies

Progenitor cell domains in the developing and adult pancreas

ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas

Coordinated regulation by Shp2 tyrosine phosphatase of signaling events controlling insulin biosynthesis in pancreatic β-cells

The SDF-1α/CXCR4 axis is required for proliferation and maturation of human fetal pancreatic endocrine progenitor cells

A Novel Approach to Increase Human Islet Cell Mass While Preserving β-Cell Function

Limited Capacity of Human Adult Islets Expanded In Vitro to Redifferentiate Into Insulin-Producing β-Cells

The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma

β-cell replication and islet neogenesis following partial pancreatectomy

Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cells

Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1

Maternal embryonic leucine zipper kinase regulates pancreatic ductal, but not β‐cell, regeneration

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

Human embryonic stem cell derived islet progenitors mature inside an encapsulation device without evidence of increased biomass or cell escape

Pancreatic β‐Cell Neogenesis by Direct Conversion from Mature α‐Cells

Efficient [beta]-Cell Regeneration by a Combination of Neogenesis and Replication Following [beta]-Cell Ablation and Reversal of Pancreatic Duct Ligation

Insulin acts as a repressive factor to inhibit the ability of PAR2 to induce islet cell transdifferentiation

Loss of TRB3 Alters Dynamics of MLK3-JNK Signaling and Inhibits Cytokine-activated Pancreatic Beta Cell Death

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