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Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Cell reports (Cambridge), 2021-01, Vol.34 (1), p.108588-108588, Article 108588

2021

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Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

Trends in pharmacological sciences (Regular ed.), 2020-04, Vol.41 (4), p.281-293

2020

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cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

Experimental neurology, 2020-07, Vol.329, p.113252-113252, Article 113252

2020

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Studies to Assess the Utility of Serum Neurofilament Light Chain as a Biomarker in Chemotherapy-Induced Peripheral Neuropathy

Cancers, 2023-08, Vol.15 (17), p.4216

2023

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Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury

The European journal of neuroscience, 2005-08, Vol.22 (3), p.587-594

2005

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Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists

Journal of medicinal chemistry, 2004-12, Vol.47 (25), p.6218-6229

2004

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The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Nature (London), 2016-09, Vol.537 (7618), p.50-56

2016

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Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

Brain (London, England : 1878), 2021-11, Vol.144 (10), p.3226-3238

2021

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D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

Science (American Association for the Advancement of Science), 1990-12, Vol.250 (4986), p.1429-1432

1990

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Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy

The Journal of clinical investigation, 2003-02, Vol.111 (4), p.507-514

2003

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SARM1 Loss of Function in Chronic and Acute CNS Axonopathies (P1.2-085)

Neurology, 2019-04, Vol.92 (15_supplement)

2019

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Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil

Neuroscience letters, 1998-01, Vol.241 (2), p.95-98

1998

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NMDA receptor blockade reverses motor response alterations induced by levodopa

Neuroreport, 1994-12, Vol.5 (18), p.2586-2588

1994

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Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration

Brain research, 1994-10, Vol.662 (1), p.69-74

1994

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Long‐acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

Journal of pharmaceutical sciences, 2002-02, Vol.91 (2), p.371-387

2002

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Motor response complications and the function of striatal efferent systems

Neurology, 1993-12, Vol.43 (12 Suppl 6), p.S23

1993

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Synthesis of alkyne derivatives of a novel triazolopyrazine as A2A adenosine receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.511-515

2005

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Addendum: The antibody aducanumab reduces A plaques in Alzheimers disease

Nature (London), 2017-06, Vol.546 (7659), p.564

2017

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Human-derived monoclonal antibodies for Alzheimer’s disease and related proteinopathies

Neurobiology of aging, 2016-03, Vol.39, p.S25-S25

2016

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Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Nature (London), 2017-06, Vol.546 (7659), p.564-564

2017

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Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4835-4838

2004

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First Synthesis of Piperazine-derived [1,2,4]Triazolo[1,5-a]pyrazine as an Adenosine A2A Receptor Antagonist

Heterocycles, 2005-10, Vol.65 (10), p.2321

2005

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The antibody aducanumab reduces A plaques in Alzheimers disease

Nature (London), 2016-09, Vol.537 (7618), p.50

2016

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Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A 2a receptor antagonists

Bioorganic & medicinal chemistry letters, 2004-10, Vol.14 (19), p.4835-4838

2004

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Synthesis of alkyne derivatives of a novel triazolopyrazine as A 2A adenosine receptor antagonists

Bioorganic & medicinal chemistry letters, 2005-02, Vol.15 (3), p.511-515

2005

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Small Molecule SARM1 Inhibitors Recapitulate the SARM1−/− Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate

Axons Matter: The Promise of Treating Neurodegenerative Disorders by Targeting SARM1-Mediated Axonal Degeneration

cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons

Studies to Assess the Utility of Serum Neurofilament Light Chain as a Biomarker in Chemotherapy-Induced Peripheral Neuropathy

Effect of combined treatment with methylprednisolone and soluble Nogo-66 receptor after rat spinal cord injury

Novel Bicyclic Piperazine Derivatives of Triazolotriazine and Triazolopyrimidines as Highly Potent and Selective Adenosine A2A Receptor Antagonists

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Pharmacological SARM1 inhibition protects axon structure and function in paclitaxel-induced peripheral neuropathy

D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons

Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy

SARM1 Loss of Function in Chronic and Acute CNS Axonopathies (P1.2-085)

Differential patterns of regional c-Fos induction in the rat brain by amphetamine and the novel wakefulness-promoting agent modafinil

NMDA receptor blockade reverses motor response alterations induced by levodopa

Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration

Long‐acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

Motor response complications and the function of striatal efferent systems

Synthesis of alkyne derivatives of a novel triazolopyrazine as A2A adenosine receptor antagonists

Addendum: The antibody aducanumab reduces A plaques in Alzheimers disease

Human-derived monoclonal antibodies for Alzheimer’s disease and related proteinopathies

Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A2a receptor antagonists

First Synthesis of Piperazine-derived [1,2,4]Triazolo[1,5-a]pyrazine as an Adenosine A2A Receptor Antagonist

The antibody aducanumab reduces A plaques in Alzheimers disease

Triamino derivatives of triazolotriazine and triazolopyrimidine as adenosine A 2a receptor antagonists

Synthesis of alkyne derivatives of a novel triazolopyrazine as A 2A adenosine receptor antagonists

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