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Targeting mesothelin in cancer

Molecular therapy. Oncolytics, 2023-12, Vol.31, p.100756-100756, Article 100756

Elbi, Cem

2023

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First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors

Journal of clinical oncology, 2020-06, Vol.38 (16), p.1824-1835

2020

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FGFR2-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival

Cancer research (Chicago, Ill.), 2008-04, Vol.68 (7), p.2340-2348

2008

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Developing a fit-for-purpose composite symptom score as a symptom burden endpoint for clinical trials in patients with malignant pleural mesothelioma

Scientific reports, 2024-06, Vol.14 (1), p.14839-10, Article 14839

2024

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Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins

Molecular and Cellular Biology, 2004-07, Vol.24 (14), p.6393-6402

2004

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Ligand-Specific Dynamics of the Androgen Receptor at Its Response Element in Living Cells

Molecular and Cellular Biology, 2007-03, Vol.27 (5), p.1823-1843

2007

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Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer

Oncogene, 2005-07, Vol.24 (31), p.4934-4945

2005

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Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus

The Journal of biological chemistry, 2006-08, Vol.281 (34), p.24588-24601

2006

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Molecular Chaperones Function as Steroid Receptor Nuclear Mobility Factors

Proceedings of the National Academy of Sciences - PNAS, 2004-03, Vol.101 (9), p.2876-2881

2004

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Ligand-Specific Dynamics of the Progesterone Receptor in Living Cells and during Chromatin Remodeling In Vitro

Molecular and Cellular Biology, 2005-03, Vol.25 (6), p.2406-2418

2005

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Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer

Cancer research (Chicago, Ill.), 2004-04, Vol.64 (7), p.2365-2370

2004

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Evaluation of the psychometric properties and minimally important difference of the MD Anderson Symptom Inventory for malignant pleural mesothelioma (MDASI-MPM)

Journal of patient-reported outcomes, 2019-06, Vol.3 (1), p.34-34, Article 34

2019

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The Ligand Binding Domain Controls Glucocorticoid Receptor Dynamics Independent of Ligand Release

Molecular and Cellular Biology, 2007-04, Vol.27 (7), p.2442-2451

2007

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Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins

Oncogene, 2004-05, Vol.23 (25), p.4400-4412

2004

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Recruitment of dioxin receptor to active transcription sites

Molecular biology of the cell, 2002-06, Vol.13 (6), p.2001-2015

2002

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Molecular Cloning and Characterization of STAMP1, a Highly Prostate-specific Six Transmembrane Protein that Is Overexpressed in Prostate Cancer

The Journal of biological chemistry, 2002-09, Vol.277 (39), p.36689-36696

2002

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Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage

Oncogene, 2004-01, Vol.23 (1), p.49-57

2004

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Trafficking of nuclear receptors in living cells

Journal of steroid biochemistry and molecular biology, 2000-11, Vol.74 (5), p.249-254

2000

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Chromatin dynamics and the evolution of alternate promoter states

Chromosome research, 2006-02, Vol.14 (1), p.107-116

2006

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Turkish Ministry of Health, 2nd Turkish Medical General Assembly Clinical Oncology Study Group Report

The journal of breast health, 2016-01, Vol.12 (1), p.9-17

2016

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Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models

Oncotarget, 2018-09, Vol.9 (75), p.34103-34121

2018

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Abstract 4816: Anetumab ravtansine has monotherapy efficacy in mesothelin positive patient-derived NSCLC tumor models and in a syngeneic tumor model in immunocompetent mice

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.4816-4816

2019

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Safety and activity of anti-mesothelin antibody–drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study

International journal of gynecological cancer, 2023-04, Vol.33 (4), p.1-9

2023

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Abstract 1780: Anetumab ravtansine has single-agent activity in mesothelin-expressing human ovarian cancer models and potentiates the activity of chemotherapeutics and targeted agents

Cancer research (Chicago, Ill.), 2018-07, Vol.78 (13_Supplement), p.1780-1780

2018

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Targeting mesothelin in cancer

First-in-Human, Multicenter, Phase I Dose-Escalation and Expansion Study of Anti-Mesothelin Antibody-Drug Conjugate Anetumab Ravtansine in Advanced or Metastatic Solid Tumors

FGFR2-Amplified Gastric Cancer Cell Lines Require FGFR2 and Erbb3 Signaling for Growth and Survival

Developing a fit-for-purpose composite symptom score as a symptom burden endpoint for clinical trials in patients with malignant pleural mesothelioma

Global Nature of Dynamic Protein-Chromatin Interactions In Vivo: Three-Dimensional Genome Scanning and Dynamic Interaction Networks of Chromatin Proteins

Ligand-Specific Dynamics of the Androgen Receptor at Its Response Element in Living Cells

Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer

Nonsecreted Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) Can Induce Apoptosis in Human Prostate Cancer Cells by IGF-independent Mechanisms without Being Concentrated in the Nucleus

Molecular Chaperones Function as Steroid Receptor Nuclear Mobility Factors

Ligand-Specific Dynamics of the Progesterone Receptor in Living Cells and during Chromatin Remodeling In Vitro

Kallikrein 4 is a predominantly nuclear protein and is overexpressed in prostate cancer

Evaluation of the psychometric properties and minimally important difference of the MD Anderson Symptom Inventory for malignant pleural mesothelioma (MDASI-MPM)

The Ligand Binding Domain Controls Glucocorticoid Receptor Dynamics Independent of Ligand Release

Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins

Recruitment of dioxin receptor to active transcription sites

Molecular Cloning and Characterization of STAMP1, a Highly Prostate-specific Six Transmembrane Protein that Is Overexpressed in Prostate Cancer

Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage

Trafficking of nuclear receptors in living cells

Chromatin dynamics and the evolution of alternate promoter states

Turkish Ministry of Health, 2nd Turkish Medical General Assembly Clinical Oncology Study Group Report

Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial

Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models

Abstract 4816: Anetumab ravtansine has monotherapy efficacy in mesothelin positive patient-derived NSCLC tumor models and in a syngeneic tumor model in immunocompetent mice

Safety and activity of anti-mesothelin antibody–drug conjugate anetumab ravtansine in combination with pegylated-liposomal doxorubicin in platinum-resistant ovarian cancer: multicenter, phase Ib dose escalation and expansion study

Abstract 1780: Anetumab ravtansine has single-agent activity in mesothelin-expressing human ovarian cancer models and potentiates the activity of chemotherapeutics and targeted agents

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