UB Paderborn / Katalog / Suche / in CDI

1 – 25 von 96

Sortiert nach

Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges

Bioorganic & medicinal chemistry letters, 2019-07, Vol.29 (13), p.1555-1564

2019

Volltextzugriff (PDF)

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279

Journal of medicinal chemistry, 2023-08, Vol.66 (15), p.10473-10496

2023

Volltextzugriff (PDF)

Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10460-10473

2020

Volltextzugriff (PDF)

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Journal of medicinal chemistry, 2021-10, Vol.64 (19), p.14498-14512

2021

Volltextzugriff (PDF)

Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

Journal of medicinal chemistry, 2014-02, Vol.57 (4), p.1437-1453

2014

Volltextzugriff (PDF)

Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity

Biochemistry (Easton), 2004-05, Vol.43 (20), p.6091-6100

2004

Volltextzugriff (PDF)

Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors

Bioorganic & medicinal chemistry letters, 2020-11, Vol.30 (22), p.127523-127523, Article 127523

2020

Volltextzugriff (PDF)

Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis

Bioorganic & medicinal chemistry letters, 2022-10, Vol.73, p.128891-128891, Article 128891

2022

Volltextzugriff (PDF)

Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors

Bioorganic & medicinal chemistry letters, 2023-07, Vol.91, p.129352-129352, Article 129352

2023

Volltextzugriff (PDF)

Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase

Bioorganic & medicinal chemistry letters, 2020-09, Vol.30 (18), p.127393-127393, Article 127393

2020

Volltextzugriff (PDF)

Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Bioorganic & medicinal chemistry letters, 2020-10, Vol.30 (19), p.127433, Article 127433

2020

Volltextzugriff (PDF)

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry letters, 2006-10, Vol.16 (20), p.5373-5377

2006

Volltextzugriff (PDF)

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents

ACS medicinal chemistry letters, 2017-01, Vol.8 (1), p.96-101

2017

Volltextzugriff (PDF)

Discovery of phenyl acetamides as potent and selective GPR119 agonists

Bioorganic & medicinal chemistry letters, 2017-03, Vol.27 (5), p.1124-1128

2017

Volltextzugriff (PDF)

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1094-1098

2017

Volltextzugriff (PDF)

Investigation of piperazine benzamides as human β 3 adrenergic receptor agonists for the treatment of overactive bladder

Bioorganic & medicinal chemistry letters, 2017-02, Vol.27 (4), p.1094-1098

2017

Volltextzugriff (PDF)

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

Bioorganic & medicinal chemistry, 2008-04, Vol.18 (7), p.2409-2413

2008

Volltextzugriff (PDF)

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

ACS medicinal chemistry letters, 2016-12, Vol.7 (12), p.1107-1111

2016

Volltextzugriff (PDF)

Palladium-Catalyzed Coupling of Vinylogous Amides with Aryl Halides: Applications to the Synthesis of Heterocycles

Organic letters, 2000-04, Vol.2 (8), p.1109-1112

2000

Volltextzugriff (PDF)

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

ACS medicinal chemistry letters, 2015-08, Vol.6 (8), p.936-941

2015

Volltextzugriff (PDF)

Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate)

Bioorganic & medicinal chemistry letters, 2007-06, Vol.17 (12), p.3373-3377

2007

Volltextzugriff (PDF)

The Total Synthesis of Spirotryprostatin A

Angewandte Chemie (International ed.), 1998-05, Vol.37 (8), p.1138-1140

1998

Volltextzugriff (PDF)

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Bioorganic & medicinal chemistry letters, 2011-05, Vol.21 (10), p.2911-2915

2011

Volltextzugriff (PDF)

1 – 25 von 96

Suche als RSS-Feed

Suchergebnisse filtern

Filter anzeigen

Nur zeigen

Geprüft (Peer-Review)
(83)
Mit Volltextzugriff
(94)

Publikationsform

Sprache

Englisch
(95)
Japanisch
(16)
Deutsch
(1)

Erscheinungsjahr

n.n

Thema

Science & Technology
(58)
Life Sciences & Biomedicine
(49)
Humans
(33)
Chemistry
(30)
Physical Sciences
(30)
Chemistry, Medicinal
(26)
Pharmacology & Pharmacy
(26)
Chemistry, Organic
(24)
Animals
(23)
Biological And Medical Sciences
(18)
Medical Sciences
(18)
Pharmacology. Drug Treatments
(16)
Structure-Activity Relationship
(15)
Rats
(14)
Female
(13)
General And Cellular Metabolism. Vitamins
(11)
Male
(11)
Mice
(9)
Adult
(7)
Molecular Structure
(7)

15 weitere anzeigen...

Weniger anzeigen...

Menü

Weitere Dienste

Einstellungen

Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’ chemical space: Recent progress and future challenges

Discovery of a Potent and Selective Tyrosine Kinase 2 Inhibitor: TAK-279

Discovery of Proteolysis-Targeting Chimera Molecules that Selectively Degrade the IRAK3 Pseudokinase

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

Design, Synthesis, and Evaluation of Conformationally Restricted Acetanilides as Potent and Selective β3 Adrenergic Receptor Agonists for the Treatment of Overactive Bladder

Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity

Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors

Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of psoriasis

Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors

Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase

Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors

Discovery of Chromane Propionic Acid Analogues as Selective Agonists of GPR120 with in Vivo Activity in Rodents

Discovery of phenyl acetamides as potent and selective GPR119 agonists

Investigation of piperazine benzamides as human β3 adrenergic receptor agonists for the treatment of overactive bladder

Investigation of piperazine benzamides as human β 3 adrenergic receptor agonists for the treatment of overactive bladder

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: A Selective α-Amino Amide Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes

Palladium-Catalyzed Coupling of Vinylogous Amides with Aryl Halides: Applications to the Synthesis of Heterocycles

Design of Potent and Orally Active GPR119 Agonists for the Treatment of Type II Diabetes

Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIA™ (sitagliptin phosphate)

The Total Synthesis of Spirotryprostatin A

Discovery of pyrimidine carboxamides as potent and selective CCK1 receptor agonists

Suchergebnisse filtern