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A Phase I Study of LGD1069 in Adults with Advanced Cancer

Clinical cancer research, 1999-07, Vol.5 (7), p.1658-1664

1999

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Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid

Clinical cancer research, 1996-03, Vol.2 (3), p.471-475

1996

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Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes

Drug metabolism and disposition, 1998-03, Vol.26 (3), p.234

1998

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Phase I study of 9-cis-retinoic acid (ALRT1057 capsules) in adults with advanced cancer

Clinical cancer research, 1998-06, Vol.4 (6), p.1437-1442

1998

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Biotransformation of lovastatin. V. Species differences in in vivo metabolite profiles of mouse, rat, dog, and human

Drug metabolism and disposition, 1993-11, Vol.21 (6), p.1003

1993

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Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate

Drug metabolism and disposition, 1996-03, Vol.24 (3), p.293

1996

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Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine

Journal of medicinal chemistry, 1985-12, Vol.28 (12), p.1779-1790

1985

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A new class of angiotensin-converting enzyme inhibitors

Nature (London), 1980-11, Vol.288 (5788), p.280-283

1980

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Kinetic studies on the competition between famotidine and cimetidine in rats. Evidence of multiple renal secretory systems for organic cations

Drug metabolism and disposition, 1988-01, Vol.16 (1), p.52

1988

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Differential renal handling of angiotensin-converting enzyme inhibitors enalaprilat and lisinopril in rats

Drug metabolism and disposition, 1988-05, Vol.16 (3), p.392

1988

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Pharmacokinetics of 9-cis-retinoic acid in the rhesus monkey

Cancer research (Chicago, Ill.), 1995-02, Vol.55 (3), p.482-485

1995

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Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors

Drug metabolism and disposition, 2001-07, Vol.29 (7), p.990

2001

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Dose-dependent stereopharmacokinetics of 5,6-dihydro-4H-4(isobutylamino)thieno(2,3-B)thiopyran-2-sulfonamide-7,7 -dioxide , a potent carbonic anhydrase inhibitor, in rats

Drug metabolism and disposition, 1991-01, Vol.19 (1), p.233

1991

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Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse

Drug metabolism and disposition, 1990-03, Vol.18 (2), p.203

1990

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Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect

The Journal of pharmacology and experimental therapeutics, 1985-06, Vol.233 (3), p.788

1985

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Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes

Drug metabolism and disposition, 1984-05, Vol.12 (3), p.309

1984

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Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats

The Journal of pharmacology and experimental therapeutics, 1987-09, Vol.242 (3), p.1013

1987

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Urinary excretion kinetics of famotidine in rats

Drug metabolism and disposition, 1987-03, Vol.15 (2), p.212

1987

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Effect of experimental diabetes on elimination kinetics of diflunisal in rats

Drug metabolism and disposition, 1989-03, Vol.17 (2), p.147

1989

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Conformationally restricted inhibitors of angiotensin-converting enzyme. Synthesis and computations

Journal of medicinal chemistry, 1986-02, Vol.29 (2), p.251-260

1986

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Phosphorus-Containing Inhibitors of Angiotensin-Converting Enzyme

Proceedings of the National Academy of Sciences - PNAS, 1982-04, Vol.79 (7), p.2176-2180

1982

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Dose-dependent kinetics of cilastatin in laboratory animals

Drug metabolism and disposition, 1989-07, Vol.17 (4), p.426

1989

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Dose-dependent pharmacokinetics of MK-417, a potent carbonic anhydrase inhibitor, in rabbits following single and multiple doses

Drug metabolism and disposition, 1990-11, Vol.18 (6), p.836

1990

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Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo

The Journal of pharmacology and experimental therapeutics, 1981-03, Vol.216 (3), p.552

1981

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The physiological disposition and metabolism of enalapril maleate in laboratory animals

Drug metabolism and disposition, 1982-01, Vol.10 (1), p.15

1982

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A Phase I Study of LGD1069 in Adults with Advanced Cancer

Initial clinical trial of the retinoid receptor pan agonist 9-cis retinoic acid

Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor/retinoid x receptor selectivity and effects on metabolic enzymes

Phase I study of 9-cis-retinoic acid (ALRT1057 capsules) in adults with advanced cancer

Biotransformation of lovastatin. V. Species differences in in vivo metabolite profiles of mouse, rat, dog, and human

Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate

Renin inhibitors. Syntheses of subnanomolar, competitive, transition-state analog inhibitors containing a novel analog of statine

A new class of angiotensin-converting enzyme inhibitors

Kinetic studies on the competition between famotidine and cimetidine in rats. Evidence of multiple renal secretory systems for organic cations

Differential renal handling of angiotensin-converting enzyme inhibitors enalaprilat and lisinopril in rats

Pharmacokinetics of 9-cis-retinoic acid in the rhesus monkey

Bexarotene metabolism in rat, dog, and human, synthesis of oxidative metabolites, and in vitro activity at retinoid receptors

Dose-dependent stereopharmacokinetics of 5,6-dihydro-4H-4(isobutylamino)thieno(2,3-B)thiopyran-2-sulfonamide-7,7 -dioxide , a potent carbonic anhydrase inhibitor, in rats

Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse

Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect

Disposition of enalapril and its diacid metabolite, enalaprilat, in a perfused rat liver preparation. Presence of a diffusional barrier for enalaprilat into hepatocytes

Differential effects of phenobarbital on ester and ether glucuronidation of diflunisal in rats

Urinary excretion kinetics of famotidine in rats

Effect of experimental diabetes on elimination kinetics of diflunisal in rats

Conformationally restricted inhibitors of angiotensin-converting enzyme. Synthesis and computations

Phosphorus-Containing Inhibitors of Angiotensin-Converting Enzyme

Dose-dependent kinetics of cilastatin in laboratory animals

Dose-dependent pharmacokinetics of MK-417, a potent carbonic anhydrase inhibitor, in rabbits following single and multiple doses

Effect of N-[(S)-1-carboxy-3-phenylpropyl]-L-Ala-L-Pro and its ethyl ester (MK-421) on angiotensin converting enzyme in vitro and angiotensin I pressor responses in vivo

The physiological disposition and metabolism of enalapril maleate in laboratory animals

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