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Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin

Molecules (Basel, Switzerland), 2021-12, Vol.26 (24), p.7494

2021

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Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum

Heliyon, 2023-07, Vol.9 (7), p.e18299-e18299, Article e18299

2023

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Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

South African Journal of Science, 2016-11, Vol.112 (11-12), p.111-199

2016

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Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis

Molecules (Basel, Switzerland), 2017-03, Vol.22 (4), p.513

2017

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New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara)

Fitoterapia, 2021-11, Vol.155, p.105041, Article 105041

2021

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Exploring the transmission-blocking activity of antiplasmodial 3,6-diarylated imidazopyridazines

Transactions of the Royal Society of South Africa, 2021-09, Vol.76 (3), p.225-233

2021

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Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean : research letter

South African journal of science, 2016-11, Vol.112 (11), p.111-115

2016

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Synthesis and Evaluation of Chalcone-Quinoline Based Molecular Hybrids as Potential Anti-Malarial Agents

Molecules (Basel, Switzerland), 2021-07, Vol.26 (13), p.4093

2021

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Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)

Journal of medicinal chemistry, 2020-05, Vol.63 (9), p.4445-4467

2020

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The dichapetalins and dichapetalin-type compounds: structural diversity, bioactivity, and future research perspectives

Natural product reports, 2024-07

2024

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Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin

MedChemComm, 2019-06, Vol.1 (6), p.961-969

2019

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The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics

Nature reviews. Chemistry, 2023-05, Vol.7 (5), p.340

2023

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Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Bioorganic & medicinal chemistry, 2020-07, Vol.28 (13), p.115530-115530, Article 115530

2020

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Rv0684/fusA1, an Essential Gene, Is the Target of Fusidic Acid and Its Derivatives in Mycobacterium tuberculosis

ACS infectious diseases, 2021-08, Vol.7 (8), p.2437-2444

2021

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Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

RSC medicinal chemistry, 2020-04, Vol.11 (4), p.455-49

2020

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Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity

Molecules (Basel, Switzerland), 2017-03, Vol.22 (4), p.532

2017

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Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies

Journal of medicinal chemistry, 2021-04, Vol.64 (8), p.5198-5215

2021

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Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00161a

MedChemComm, 2019-04, Vol.10 (6), p.961-969

2019

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2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy

Journal of medicinal chemistry, 2024-07, Vol.67 (13), p.11401-11420

2024

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Pharmacokinetics and Organ Distribution of C‑3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid

ACS infectious diseases, 2020-03, Vol.6 (3), p.459-466

2020

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Antimalarial Pyrido[1,2‑a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies

ACS infectious diseases, 2019-03, Vol.5 (3), p.372-384

2019

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Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents of Dichapetalum filicaule

Pharmaceutical biology, 2016-07, Vol.54 (7), p.1179-1188

2016

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Expanding the Activity Profile of Pyrido[1,2‑a]benzimidazoles: Synthesis and Evaluation of Novel N 1‑1-Phenylethanamine Derivatives against Schistosoma mansoni

ACS infectious diseases, 2021-05, Vol.7 (5), p.1032-1043

2021

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Semisynthetic Antimycobacterial C‑3 Silicate and C‑3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture

ACS infectious diseases, 2019-09, Vol.5 (9), p.1634-1644

2019

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Ecological feedback mechanisms and variable disturbance regimes: the uncertain future of Mediterranean macroalgal forests

Marine environmental research, 2018-09, Vol.140, p.342-357

2018

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Discovery of Novel Cyclic Ethers with Synergistic Antiplasmodial Activity in Combination with Valinomycin

Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum

Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

Isolation, Characterization and Antiproliferative Activity of New Metabolites from the South African Endemic Red Algal Species Laurencia alfredensis

New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara)

Exploring the transmission-blocking activity of antiplasmodial 3,6-diarylated imidazopyridazines

Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean : research letter

Synthesis and Evaluation of Chalcone-Quinoline Based Molecular Hybrids as Potential Anti-Malarial Agents

Plasmepsin Inhibitors in Antimalarial Drug Discovery: Medicinal Chemistry and Target Validation (2000 to Present)

The dichapetalins and dichapetalin-type compounds: structural diversity, bioactivity, and future research perspectives

Novel antimycobacterial C-21 amide derivatives of the antibiotic fusidic acid: synthesis, pharmacological evaluation and rationalization of media-dependent activity using molecular docking studies in the binding site of human serum albumin

The implication of Mycobacterium tuberculosis-mediated metabolism of targeted xenobiotics

Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity

Rv0684/fusA1, an Essential Gene, Is the Target of Fusidic Acid and Its Derivatives in Mycobacterium tuberculosis

Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

Constituents of the Roots of Dichapetalum pallidum and Their Anti-Proliferative Activity

Antimalarial Benzimidazole Derivatives Incorporating Phenolic Mannich Base Side Chains Inhibit Microtubule and Hemozoin Formation: Structure–Activity Relationship and In Vivo Oral Efficacy Studies

2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy

Pharmacokinetics and Organ Distribution of C‑3 Alkyl Esters as Potential Antimycobacterial Prodrugs of Fusidic Acid

Antimalarial Pyrido[1,2‑a]benzimidazole Derivatives with Mannich Base Side Chains: Synthesis, Pharmacological Evaluation, and Reactive Metabolite Trapping Studies

Isolation, characterization, and anthelminthic activities of a novel dichapetalin and other constituents of Dichapetalum filicaule

Expanding the Activity Profile of Pyrido[1,2‑a]benzimidazoles: Synthesis and Evaluation of Novel N 1‑1-Phenylethanamine Derivatives against Schistosoma mansoni

Semisynthetic Antimycobacterial C‑3 Silicate and C‑3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture

Ecological feedback mechanisms and variable disturbance regimes: the uncertain future of Mediterranean macroalgal forests

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