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The significance of mitochondrial toxicity testing in drug development

Drug discovery today, 2007-09, Vol.12 (17), p.777-785

2007

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Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

Toxicology and applied pharmacology, 2008-12, Vol.233 (2), p.203-210

2008

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Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

Toxicological sciences, 2008-11, Vol.106 (1), p.153-161

2008

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In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

Toxicological sciences, 2008-06, Vol.103 (2), p.335-345

2008

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Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Yvonne Will, James A. Dykens

2, 2018

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Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

Toxicology and applied pharmacology, 2007-09, Vol.223 (3), p.277-287

2007

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Novel Mechanisms for Estrogen-Induced Neuroprotection

Experimental Biology and Medicine, 2006-05, Vol.231 (5), p.514-521

2006

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Drug-Induced Mitochondrial Dysfunction

1. Aufl., 2008

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Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

Toxicological sciences, 2007-06, Vol.97 (2), p.539-547

2007

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Mitochondrial mechanisms of estrogen neuroprotection

Biochimica et biophysica acta, 2010-10, Vol.1800 (10), p.1113-1120

2010

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Strategies to reduce late-stage drug attrition due to mitochondrial toxicity

Expert review of molecular diagnostics, 2007-03, Vol.7 (2), p.161-175

2007

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Mitochondrial dysfunction by drug and environmental toxicants

1st, 2018

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Mitochondrial Drugs Come of Age

Drug development research, 2015-03, Vol.76 (2), p.57-60

2015

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Mitochondrial mechanisms of estrogen neuroprotection

Brain Research Reviews, 2008-03, Vol.57 (2), p.421-430

2008

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Mitochondria play a central role in estrogen-induced neuroprotection

Current drug targets. CNS & neurological disorders, 2005-02, Vol.4 (1), p.69

2005

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Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for Neurodegeneration

Journal of neurochemistry, 1994-08, Vol.63 (2), p.584-591

Dykens, James A.

1994

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Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability

Investigative ophthalmology & visual science, 2003-05, Vol.44 (5), p.2067-2075

2003

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Development of 17α-Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study

Annals of the New York Academy of Sciences, 2005-06, Vol.1052 (1), p.116-135

2005

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Oxygen radical production in the sea anemone Anthopleura elegantissima and its endosymbiotic algae

Journal of experimental biology, 1992-07, Vol.168 (1), p.219-241

1992

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Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential

Drug development research, 2009-02, Vol.70 (1), p.1-21

2009

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Development and validation of a pre-clinically relevant phototoxicity screen

Toxicology (Amsterdam), 2010, Vol.278 (3), p.349-350

2010

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Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog

Biochemical pharmacology, 2004-11, Vol.68 (10), p.1971-1984

2004

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A current practice for predicting ocular toxicity of systemically delivered drugs

Cutaneous and ocular toxicology, 2009-03, Vol.28 (1), p.1-18

2009

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Human neutrophil (PMN) oxygen radical production and the cytoskeleton

Life sciences (1973), 1995, Vol.57 (16), p.1533-1546

1995

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High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer

Mitochondrion, 2002-05, Vol.1 (5), p.461-473

2002

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The significance of mitochondrial toxicity testing in drug development

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

In Vitro Assessment of Mitochondrial Dysfunction and Cytotoxicity of Nefazodone, Trazodone, and Buspirone

Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants

Mitochondrial impairment by PPAR agonists and statins identified via immunocaptured OXPHOS complex activities and respiration

Novel Mechanisms for Estrogen-Induced Neuroprotection

Drug-Induced Mitochondrial Dysfunction

Circumventing the Crabtree Effect: Replacing Media Glucose with Galactose Increases Susceptibility of HepG2 Cells to Mitochondrial Toxicants

Mitochondrial mechanisms of estrogen neuroprotection

Strategies to reduce late-stage drug attrition due to mitochondrial toxicity

Mitochondrial dysfunction by drug and environmental toxicants

Mitochondrial Drugs Come of Age

Mitochondrial mechanisms of estrogen neuroprotection

Mitochondria play a central role in estrogen-induced neuroprotection

Isolated Cerebral and Cerebellar Mitochondria Produce Free Radicals when Exposed to Elevated Ca2+ and Na+: Implications for Neurodegeneration

Oxidative Damage to Human Lens Epithelial Cells in Culture: Estrogen Protection of Mitochondrial Potential, ATP, and Cell Viability

Development of 17α-Estradiol as a Neuroprotective Therapeutic Agent: Rationale and Results from a Phase I Clinical Study

Oxygen radical production in the sea anemone Anthopleura elegantissima and its endosymbiotic algae

Review of the effects of 17α-estradiol in humans: a less feminizing estrogen with neuroprotective potential

Development and validation of a pre-clinically relevant phototoxicity screen

Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog

A current practice for predicting ocular toxicity of systemically delivered drugs

Human neutrophil (PMN) oxygen radical production and the cytoskeleton

High-throughput assessment of mitochondrial membrane potential in situ using fluorescence resonance energy transfer

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