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Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Bone (New York, N.Y.), 2012-01, Vol.50 (1), p.209-217

2012

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Effects of Parathyroid Hormone Treatment on Circulating Sclerostin Levels in Postmenopausal Women

The journal of clinical endocrinology and metabolism, 2010-11, Vol.95 (11), p.5056-5062

2010

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Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Journal of bone and mineral research, 2008-06, Vol.23 (6), p.860-869

2008

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Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

Journal of bone and mineral research, 2011-05, Vol.26 (5), p.1012-1021

2011

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Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

Journal of bone and mineral research, 2013-04, Vol.28 (4), p.865-874

2013

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Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

Journal of bone and mineral research, 2010-12, Vol.25 (12), p.2647-2656

2010

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Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis

Annals of the rheumatic diseases, 2013-10, Vol.72 (10), p.1732-1736

2013

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Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

Bone (New York, N.Y.), 2014-10, Vol.67, p.305-313

2014

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The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15

PloS one, 2020-08, Vol.15 (8), p.e0231234-e0231234

2020

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Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction

Scientific reports, 2021-06, Vol.11 (1), p.11839-11839, Article 11839

2021

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GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys

Cell reports. Medicine, 2021-05, Vol.2 (5), p.100263, Article 100263

2021

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Evolving Systemic and Local Biomarker Milieu at Different Stages of Disease Progression in Rat Adjuvant-Induced Arthritis

Journal of clinical immunology, 2009-03, Vol.29 (2), p.158-174

2009

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Continuous RANKL Inhibition in Osteoprotegerin Transgenic Mice and Rats Suppresses Bone Resorption without Impairing Lymphorganogenesis or Functional Immune Responses

The Journal of immunology (1950), 2007-12, Vol.179 (11), p.7497-7505

2007

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RANKL is a Marker and Mediator of Local and Systemic Bone Loss in Two Rat Models of Inflammatory Arthritis

Journal of bone and mineral research, 2005-10, Vol.20 (10), p.1756-1765

2005

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FRET Detection of Cellular α4-Integrin Conformational Activation

Biophysical journal, 2003-12, Vol.85 (6), p.3951-3962

2003

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Real-time Analysis of Very Late Antigen-4 Affinity Modulation by Shear

The Journal of biological chemistry, 2004-09, Vol.279 (37), p.38277-38286

2004

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Dickkopf-1 is a master regulator of joint remodeling

Nature medicine, 2007-02, Vol.13 (2), p.156-163

2007

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The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis

Biomarkers, 2008-01, Vol.13 (7-8), p.692-712

2008

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Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr(-/-) Mice

Circulation (New York, N.Y.), 2008-01, Vol.117 (3), p.411-420

2008

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OPG‐Fc but Not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice

Journal of bone and mineral research, 2015-09, Vol.30 (9), p.1627-1640

2015

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FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

Journal of bone and mineral research, 2017-04, Vol.32 (4), p.834-845

2017

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FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPAR[alpha] and PPAR[gamma] Agonists

Journal of bone and mineral research, 2017-04, Vol.32 (4), p.834

2017

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Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis

Journal of bone and mineral research, 2019-01, Vol.34 (1), p.171-181

2019

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Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture

Regulatory toxicology and pharmacology, 2020-08, Vol.115, p.104697, Article 104697

2020

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Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody

Endocrinology (Philadelphia), 2014-12, Vol.155 (12), p.4785-4797

2014

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Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

Effects of Parathyroid Hormone Treatment on Circulating Sclerostin Levels in Postmenopausal Women

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

Sclerostin antibody inhibits skeletal deterioration due to reduced mechanical loading

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

Sclerostin inhibition reverses systemic, periarticular and local bone loss in arthritis

Temporal changes in systemic and local expression of bone turnover markers during six months of sclerostin antibody administration to ovariectomized rats

The evolving systemic biomarker milieu in obese ZSF1 rat model of human cardiometabolic syndrome: Characterization of the model and cardioprotective effect of GDF15

Chamber-enriched gene expression profiles in failing human hearts with reduced ejection fraction

GIPR antagonist antibodies conjugated to GLP-1 peptide are bispecific molecules that decrease weight in obese mice and monkeys

Evolving Systemic and Local Biomarker Milieu at Different Stages of Disease Progression in Rat Adjuvant-Induced Arthritis

Continuous RANKL Inhibition in Osteoprotegerin Transgenic Mice and Rats Suppresses Bone Resorption without Impairing Lymphorganogenesis or Functional Immune Responses

RANKL is a Marker and Mediator of Local and Systemic Bone Loss in Two Rat Models of Inflammatory Arthritis

FRET Detection of Cellular α4-Integrin Conformational Activation

Real-time Analysis of Very Late Antigen-4 Affinity Modulation by Shear

Dickkopf-1 is a master regulator of joint remodeling

The evolving systemic and local biomarker milieu at different stages of disease progression in rat collagen-induced arthritis

Osteoprotegerin Inhibits Vascular Calcification Without Affecting Atherosclerosis in ldlr(-/-) Mice

OPG‐Fc but Not Zoledronic Acid Discontinuation Reverses Osteonecrosis of the Jaws (ONJ) in Mice

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists

FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPAR[alpha] and PPAR[gamma] Agonists

Clinically Relevant Doses of Sclerostin Antibody Do Not Induce Osteonecrosis of the Jaw (ONJ) in Rats with Experimental Periodontitis

Nonclinical cardiovascular safety evaluation of romosozumab, an inhibitor of sclerostin for the treatment of osteoporosis in postmenopausal women at high risk of fracture

Progressive Increases in Bone Mass and Bone Strength in an Ovariectomized Rat Model of Osteoporosis After 26 Weeks of Treatment With a Sclerostin Antibody

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