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Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity

Journal of medicinal chemistry, 2001-11, Vol.44 (23), p.3965-3977

2001

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Synthesis and Src Kinase Inhibitory Activity of a Series of 4-Phenylamino-3-quinolinecarbonitriles

Journal of medicinal chemistry, 2001-03, Vol.44 (5), p.822-833

2001

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Indazolylpyrazolopyrimidine as Highly Potent B-Raf Inhibitors with in Vivo Activity

Journal of medicinal chemistry, 2010-11, Vol.53 (21), p.7874-7878

2010

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Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Bioorganic & medicinal chemistry letters, 2009, Vol.19 (1), p.62-66

2009

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Synthesis of 7-( E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated Heck, Stille, and Suzuki reactions

Tetrahedron, 2009-01, Vol.65 (1), p.57-61

2009

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Non-hinge-binding pyrazolo[1,5- a]pyrimidines as potent B-Raf kinase inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (23), p.6519-6523

2009

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Novel pyrazolopyrimidines as highly potent B-Raf inhibitors

Bioorganic & medicinal chemistry letters, 2009-12, Vol.19 (24), p.6957-6961

2009

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Observation of differential reactivity of cyclic amines in SN2 and SNAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors

Tetrahedron letters, 2008-01, Vol.49 (1), p.137-140

2008

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4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors

Bioorganic & medicinal chemistry, 2008-10, Vol.16 (20), p.9202-9211

2008

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Observation of differential reactivity of cyclic amines in S N2 and S NAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors

Tetrahedron letters, 2008, Vol.49 (1), p.137-140

2008

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Novel Multidrug Resistance Reversal Agents

Journal of medicinal chemistry, 1999-06, Vol.42 (12), p.2145-2161

1999

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4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors

Journal of medicinal chemistry, 2005-09, Vol.48 (19), p.5909-5920

2005

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4-Anilino-7-alkenylquinoIine-3-carbonitriles as potent MEI1 kinase inhibitors

Bioorganic & medicinal chemistry, 2008, Vol.16 (20), p.9202-9211

2008

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Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (20), p.2989-2992

2002

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Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogs

Journal of medicinal chemistry, 1989-10, Vol.32 (10), p.2318-2325

1989

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Disodium (R,R)-5[2-[[2-γ(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.3081-3084

1992

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Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.3081-3084

1992

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Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (18), p.3031-3034

2003

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8-Anilinoimidazo[4,5- g]quinoline-7-carbonitriles as Src Kinase Inhibitors

Bioorganic & medicinal chemistry letters, 2002-10, Vol.12 (19), p.2761-2765

2002

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Regioselective Synthesis ofa Potent Src Kinase Inhibitor: 4-(2,4-Dichloro-5-methoxyphenylamino)-7-methoxy-8-(2-morpholin-4-ylethoxy)benzo[ g ]quinoline-3-carbonitrile

Synthesis (Stuttgart), 2003-08, Vol.2003 (11), p.1712-1716

2003

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Regioselective Synthesis of a Potent Src Kinase Inhibitor: 4-(2,4-Dichloro-5-methoxyphenylamino)-7-methoxy-8-(2-morpholin-4-ylethoxy)benzo[g]quinoline-3-carbonitrile

Synthesis (Stuttgart), 2003-01, Vol.2003 (11)

2003

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Potential antiatherosclerotic agents. 5. An acyl-coenzyme A:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity

Journal of medicinal chemistry, 1986-07, Vol.29 (7), p.1131-1133

1986

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Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade: Recent advances in the design of kinase inhibitors as novel therapeutic agents

Bioorganic & medicinal chemistry letters, 2003, Vol.13 (18), p.3031-3034

2003

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ChemInform Abstract: Synthesis of 7-(E)-Alkenyl-4-amino-3-quinolinecarbonitriles via Pd-Mediated Heck, Stille, and Suzuki Reactions

ChemInform, 2009-05, Vol.40 (20), p.no-no

2009

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Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity

Journal of medicinal chemistry, 1986-07, Vol.29 (7), p.1131-1133

1986

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Optimization of 4-Phenylamino-3-quinolinecarbonitriles as Potent Inhibitors of Src Kinase Activity

Synthesis and Src Kinase Inhibitory Activity of a Series of 4-Phenylamino-3-quinolinecarbonitriles

Indazolylpyrazolopyrimidine as Highly Potent B-Raf Inhibitors with in Vivo Activity

Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment

Synthesis of 7-( E)-alkenyl-4-amino-3-quinolinecarbonitriles via Pd-mediated Heck, Stille, and Suzuki reactions

Non-hinge-binding pyrazolo[1,5- a]pyrimidines as potent B-Raf kinase inhibitors

Novel pyrazolopyrimidines as highly potent B-Raf inhibitors

Observation of differential reactivity of cyclic amines in SN2 and SNAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors

4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors

Observation of differential reactivity of cyclic amines in S N2 and S NAr displacement reactions in the course of synthesizing C-6, C-7 substituted quinolinecarbonitrile MEK1 kinase inhibitors

Novel Multidrug Resistance Reversal Agents

4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as Potent Src Kinase Inhibitors

4-Anilino-7-alkenylquinoIine-3-carbonitriles as potent MEI1 kinase inhibitors

Substituted 4-anilino-7-phenyl-3-quinolinecarbonitriles as Src kinase inhibitors

Potential antiatherosclerotic agents. 6. Hypocholesterolemic trisubstituted urea analogs

Disodium (R,R)-5[2-[[2-γ(3-chlorophenyl)-2-hydroxyethyl]-amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent

Synthesis and evaluation of 4-Anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade

8-Anilinoimidazo[4,5- g]quinoline-7-carbonitriles as Src Kinase Inhibitors

Regioselective Synthesis ofa Potent Src Kinase Inhibitor: 4-(2,4-Dichloro-5-methoxyphenylamino)-7-methoxy-8-(2-morpholin-4-ylethoxy)benzo[ g ]quinoline-3-carbonitrile

Regioselective Synthesis of a Potent Src Kinase Inhibitor: 4-(2,4-Dichloro-5-methoxyphenylamino)-7-methoxy-8-(2-morpholin-4-ylethoxy)benzo[g]quinoline-3-carbonitrile

Potential antiatherosclerotic agents. 5. An acyl-coenzyme A:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity

Synthesis and evaluation of 4-anilino-6,7-dialkoxy-3-quinolinecarbonitriles as inhibitors of kinases of the Ras-MAPK signaling cascade: Recent advances in the design of kinase inhibitors as novel therapeutic agents

ChemInform Abstract: Synthesis of 7-(E)-Alkenyl-4-amino-3-quinolinecarbonitriles via Pd-Mediated Heck, Stille, and Suzuki Reactions

Potential antiatherosclerotic agents. 5. An acyl-CoA:cholesterol O-acyltransferase inhibitor with hypocholesterolemic activity

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