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Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

The Journal of pharmacology and experimental therapeutics, 2002-05, Vol.301 (2), p.427-434

2002

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.70-90

2015

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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Journal of pharmacological and toxicological methods, 2018-07, Vol.92, p.43-51

2018

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Cardiovascular pressure measurement in safety assessment studies: Technology requirements and potential errors

Journal of pharmacological and toxicological methods, 2014-11, Vol.70 (3), p.210-223

Sarazan, R. Dustan

2014

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Cardiovascular Function in Nonclinical Drug Safety Assessment: Current Issues and Opportunities

International journal of toxicology, 2011-05, Vol.30 (3), p.272-286

2011

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Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil

European journal of pharmacology, 2004-10, Vol.502 (3), p.163-167

2004

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Left ventricular pressure, contractility and dP/dt(max) in nonclinical drug safety assessment studies

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.71-78

2012

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Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

ILAR journal, 2016-12, Vol.57 (2), p.120-132

2016

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An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Journal of pharmacological and toxicological methods, 2017-05, Vol.85, p.1-21

2017

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Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs

Journal of pharmacological and toxicological methods, 2010-07, Vol.62 (1), p.54-63

2010

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A public–private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.7-12

2013

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Evaluation of blood pressure measurement using a miniature blood pressure transmitter with jacketed external telemetry in cynomolgus monkeys

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.127-135

2010

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An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Journal of pharmacological and toxicological methods, 2017-05, Vol.85, p.1-21

2017

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Effects of Antipsychotic Drugs on Ito, INa, Isus, IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

Pharmaceutical research, 2006-06, Vol.23 (6), p.1133-1143

2006

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Left thoracotomy surgical approach for chronic instrumentation in dogs and monkeys providing high-quality electrocardiogram signals

Journal of pharmacological and toxicological methods, 2010-09, Vol.62 (2), p.136-142

2010

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Standing on the shoulders of giants: Dean Franklin and his remarkable contributions to physiological measurements in animals

Advances in physiology education, 2009-09, Vol.33 (3), p.144-156

2009

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Statistical power analysis for hemodynamic cardiovascular safety pharmacology studies in beagle dogs

Journal of pharmacological and toxicological methods, 2004-09, Vol.50 (2), p.121-130

2004

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A Comparison Of Two Surgical Methods For Chronic Measurement Of Blood Pressure In Juvenile Rats Through Adulthood

The FASEB journal, 2011-04, Vol.25 (S1), p.1126.5-1126.5

2011

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Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studies

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.71-78

2012

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Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.151-152

2018

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An Assessment of Drug-Induced Changes in Cardiac Inotropy and Lusitropy Parameters in Dogs: Results from a HESI-sponsored Consortium

Journal of pharmacological and toxicological methods, 2017-11, Vol.88, p.229-229

2017

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Comparison of direct and ultrasound-derived pulse wave velocity measurement in conscious and anesthetized Wistar rats

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.182-182

2015

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A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animals

Journal of pharmacological and toxicological methods, 2012-09, Vol.66 (2), p.190-190

2012

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A HESI consortium update on cardiac contractility endpoints

Journal of pharmacological and toxicological methods, 2016-09, Vol.81, p.390-391

2016

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HESI Cardic Safety Committee: Prospective studies to evaluate the sensitivity of animal models to predict effects of human drugs on cardiac contractility

Journal of pharmacological and toxicological methods, 2013-07, Vol.68 (1), p.e31-e32

2013

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Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium

The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs

Cardiovascular pressure measurement in safety assessment studies: Technology requirements and potential errors

Cardiovascular Function in Nonclinical Drug Safety Assessment: Current Issues and Opportunities

Absence of clinically important HERG channel blockade by three compounds that inhibit phosphodiesterase 5—sildenafil, tadalafil, and vardenafil

Left ventricular pressure, contractility and dP/dt(max) in nonclinical drug safety assessment studies

Technological Advances in Cardiovascular Safety Assessment Decrease Preclinical Animal Use and Improve Clinical Relevance

An evaluation of the utility of LVdP/dt40, QA interval, LVdP/dtmin and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs

A public–private consortium advances cardiac safety evaluation: Achievements of the HESI Cardiac Safety Technical Committee

Evaluation of blood pressure measurement using a miniature blood pressure transmitter with jacketed external telemetry in cynomolgus monkeys

An evaluation of the utility of LVdP/dt 40 , QA interval, LVdP/dt min and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs

Effects of Antipsychotic Drugs on Ito, INa, Isus, IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

Left thoracotomy surgical approach for chronic instrumentation in dogs and monkeys providing high-quality electrocardiogram signals

Standing on the shoulders of giants: Dean Franklin and his remarkable contributions to physiological measurements in animals

Statistical power analysis for hemodynamic cardiovascular safety pharmacology studies in beagle dogs

A Comparison Of Two Surgical Methods For Chronic Measurement Of Blood Pressure In Juvenile Rats Through Adulthood

Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studies

Echocardiography and contractility indices simultaneously evaluated in telemetered beagle dogs: A HESI sponsored cross company evaluation

An Assessment of Drug-Induced Changes in Cardiac Inotropy and Lusitropy Parameters in Dogs: Results from a HESI-sponsored Consortium

Comparison of direct and ultrasound-derived pulse wave velocity measurement in conscious and anesthetized Wistar rats

A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animals

A HESI consortium update on cardiac contractility endpoints

HESI Cardic Safety Committee: Prospective studies to evaluate the sensitivity of animal models to predict effects of human drugs on cardiac contractility

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