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Cycloisomerization of Olefins in Water

Angewandte Chemie International Edition, 2020-07, Vol.59 (31), p.12998-13003

International ed. in English, 2020

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Kinetically guided radical-based synthesis of C(sp³)–C(sp³) linkages on DNA

Proceedings of the National Academy of Sciences - PNAS, 2018-07, Vol.115 (28), p.E6404-E6410

2018

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Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria

Antimicrobial Agents and Chemotherapy, 2004-03, Vol.48 (3), p.728-738

2004

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One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis

Organic letters, 2014-08, Vol.16 (16), p.4146-4149

2014

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Comparative In Vitro Activities of AC98-6446, a Novel Semisynthetic Glycopeptide Derivative of the Natural Product Mannopeptimycin α, and Other Antimicrobial Agents against Gram-Positive Clinical Isolates

Antimicrobial Agents and Chemotherapy, 2004-03, Vol.48 (3), p.739-746

2004

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Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Molecular cancer therapeutics, 2019-11, Vol.18 (11), p.2008-2020

2019

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Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl- N′-arylthiourea inhibitors of CMV

Bioorganic & medicinal chemistry letters, 2004-07, Vol.14 (13), p.3401-3406

2004

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Thiourea inhibitors of herpes viruses. part 1: bis-(aryl)thiourea inhibitors of CMV

Bioorganic & medicinal chemistry letters, 2003-09, Vol.13 (17), p.2929-2932

2003

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Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

Bioorganic & medicinal chemistry, 2006-12, Vol.14 (23), p.7953-7961

2006

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Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2

Bioorganic & medicinal chemistry, 2007-06, Vol.15 (11), p.3635-3648

2007

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Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Bioorganic & medicinal chemistry letters, 2004-01, Vol.14 (1), p.279-282

2004

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Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model

Bioorganic & medicinal chemistry letters, 2011-08, Vol.21 (15), p.4602-4607

2011

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Cycloisomerization of Olefins in Water

Angewandte Chemie, 2020-07, Vol.132 (31), p.13098-13103

2020

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2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2

Journal of medicinal chemistry, 2005-12, Vol.48 (24), p.7560-7581

2005

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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity

Bioorganic & medicinal chemistry letters, 2011-04, Vol.21 (8), p.2278-2282

2011

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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (12), p.3627-3631

2011

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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3411-3416

2011

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Benzo[ c][2,7]naphthyridines as inhibitors of PDK-1

Bioorganic & medicinal chemistry letters, 2009-09, Vol.19 (17), p.5225-5228

2009

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The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

European journal of medicinal chemistry, 2010-04, Vol.45 (4), p.1379-1386

2010

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Total synthesis of (.+-.)-isolobophytolide and (.+-.)-crassin by titanium-induced carbonyl coupling

Journal of the American Chemical Society, 1990-09, Vol.112 (19), p.6942-6949

1990

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Solid-Phase Synthesis of Cyclic Glycopeptides Related to Mannopeptimycin Derivatives

Heterocycles, 2004, Vol.62 (1), p.131

2004

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Hydrophobic Acetal and Ketal Derivatives of Mannopeptimycin-α and Desmethylhexahydromannopeptimycin-α: Semisynthetic Glycopeptides with Potent Activity Against Gram-Positive Bacteria

Journal of medicinal chemistry, 2004-07, Vol.47 (14), p.3487-3490

2004

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Structural determination of mannopeptimycin cyclic acetals

Tetrahedron letters, 2004-07, Vol.45 (30), p.5889-5893

2004

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Stereospecific synthesis of aryl .beta.-glucosides: an application to the synthesis of a prototype corresponding to the aryloxy carbohydrate domain of vancomycin

Journal of the American Chemical Society, 1992-04, Vol.114 (9), p.3471-3475

1992

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Cycloisomerization of Olefins in Water

Kinetically guided radical-based synthesis of C(sp³)–C(sp³) linkages on DNA

Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

One-Pot Oxidation and Rearrangement of Propargylamines and in Situ Pyrazole Synthesis

Comparative In Vitro Activities of AC98-6446, a Novel Semisynthetic Glycopeptide Derivative of the Natural Product Mannopeptimycin α, and Other Antimicrobial Agents against Gram-Positive Clinical Isolates

Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Thiourea inhibitors of herpes viruses. Part 2: N-Benzyl- N′-arylthiourea inhibitors of CMV

Thiourea inhibitors of herpes viruses. part 1: bis-(aryl)thiourea inhibitors of CMV

Discovery of novel inhibitors of the ZipA/FtsZ complex by NMR fragment screening coupled with structure-based design

Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria

Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model

Cycloisomerization of Olefins in Water

2-(Quinazolin-4-ylamino)-[1,4]benzoquinones as Covalent-Binding, Irreversible Inhibitors of the Kinase Domain of Vascular Endothelial Growth Factor Receptor-2

Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity

Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model

Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity

Benzo[ c][2,7]naphthyridines as inhibitors of PDK-1

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-ylamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1)

Total synthesis of (.+-.)-isolobophytolide and (.+-.)-crassin by titanium-induced carbonyl coupling

Solid-Phase Synthesis of Cyclic Glycopeptides Related to Mannopeptimycin Derivatives

Hydrophobic Acetal and Ketal Derivatives of Mannopeptimycin-α and Desmethylhexahydromannopeptimycin-α: Semisynthetic Glycopeptides with Potent Activity Against Gram-Positive Bacteria

Structural determination of mannopeptimycin cyclic acetals

Stereospecific synthesis of aryl .beta.-glucosides: an application to the synthesis of a prototype corresponding to the aryloxy carbohydrate domain of vancomycin

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